| DC74885 |
WAY-300716 |
WAY-300716 is a useful chemical reagent for laboratory study. |
|
| DC74886 |
WAY-604116 |
WAY-604116 is a 11-β-hydroxysteroid dehydrogenase inhibitor. |
|
| DC74887 |
FIPI HCl |
FIPI is a potent and selective phospholipase D inhibitor. FIPI attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. FIPI rapidly blocks in vivo PA production with subnanomolar potency. We were surprised to find that several biological processes blocked by 1-butanol are not affected by FIPI, suggesting the need for re-evaluation of proposed FIPI does inhibit PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis, indicating potential utility for it as a therapeutic for autoimmunity and cancer metastasis. |
|
| DC74888 |
Tranylcypromine sulfate |
Tranylcypromine is a monoamine oxidase inhibitor (MAOI)—it is a nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO). It is used as an antidepressant and anxiolytic agent in the clinical treatment of mood and anxiety disorders, respectively. |
|
| DC74889 |
DOPA lipid |
DOPA lipid, also known as 18:1 PA; 1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt); PA(18:1(9Z)/18:1(9Z)); is a lipid compound. |
|
| DC74890 |
WYE-176182 |
WYE-176182 is an apical sodium-dependent bile salt transporter (SLC10A2) inhibitor |
|
| DC74891 |
WAY-348941 |
WAY-348941 is an immunosuppressive agent. |
|
| DC74892 |
WAY-638394 |
WAY-638394 is a laboratory reagent, which may be useful for treating bone deficit conditions. |
|
| DC74893 |
BMS-363131 |
BMS-363131 is very potent inhibitor of human tryptase with high selectivity versus other serine proteases, including trypsin. |
|
| DC74894 |
WAY-117885 |
WAY-117885 is a laboratory reagent, which may be used for altering the lifespan of a eukaryotic organism. |
|
| DC74895 |
Pitavastatin calcium |
Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. |
|
| DC74896 |
Benzhexol HCl |
Benzhexol, also known as Trihexyphenidyl, is an antiparkinsonian agent of the antimuscarinic class. It has been in clinical usage for decades. |
|
| DC74897 |
Bemoradan |
Bemoradan, also known as WJ-22867, is a potent, long-acting orally active inodilator and cardiotonic agent. Bemoradan is a novel, potent positive inotropic agent, demonstrated biphasic inhibition of the fraction III enzyme from canine cardiac muscle. Bemoradan is well and rapidly absorbed after oral dosing, has linear pharmacokinetics and long elimination half-lives across species. |
|
| DC74898 |
Ertugliflozin |
Ertugliflozin, also known as also known as PF-04971729, is is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 0.927 nM for the human enzyme). clinical study showed that Ertugliflozin (1-25 mg/day) improved glycaemic control, body weight and blood pressure in patients with T2DM suboptimally controlled on metformin, and was well tolerated. |
|
| DC74899 |
Kaempferol 3-glucuronide |
Kaempferol 3-glucuronide inhibits the production of reactive oxygen species (ROS) induced by fMLP in isolated human neutrophils. |
|
| DC74900 |
BMS-817378 |
BMS-817378, also known as SCR-1481B1 is a potent and selective MET inhibitor. SCR-1481B1 inhibited MET kinase with IC50 = 1.7 nM. |
|
| DC74901 |
Naftifine HCl |
Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections). Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is approximately 2–3 days. The metabolites are excreted in the urine and feces. |
|
| DC74902 |
NTNCB HCl |
NTNCB is a selective, non-peptide competitive NPY Y5 antagonist. NTNCB potently antagonizes NPY inhibition of forskolin-stimulated cAMP. NTNCB Displays some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively). |
|
| DC74903 |
Atibeprone |
Atibeprone, also known as Lu 53439, is MAO-B inhibitor. The anticonvulsant activity of inhibitors of monoamine oxidase (MAO) was reported early after the development of irreversible MAO inhibitors such as tranylcypromine, but was never clinically used because of the adverse effects of these compounds. In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A. |
|
| DC74904 |
Cefovecin Sodium |
Cefovecin, also known as UK-287074, is an antibiotic of the cephalosporin class. Cefovecin interferes with the synthesis of bacterial cell walls, by binding to penicillin binding proteins. Due to high protein-binding, it is not effective against species of Pseudomonas or Enterococcus. The maximum anti-bacterial activity occurs approximately two days after cefovecin has been administered. It is used to treat skin infections caused by Pasteurella multocida in cats, and Staphylococcus intermedius and Streptococcus canis in dogs. |
|
| DC74905 |
Quizartinib free base |
Quizartinib, also known as AC220 and AC010220, is a highly potent FMS-like receptor tyrosine kinase-3 (FLT3) inhibitor. Quizartinib free base inhibits FLT3 activity and displays antitumor properties in a mouse MV4-11 tumor xenograft model. |
|
| DC74906 |
DOTA-TATE acetate |
DOTA-TATE (DOTATATE, DOTA-octreotate, oxodotreotide, DOTA-(Tyr3)-octreotate, and DOTA-0-Tyr3-Octreotate) is an eight amino acid long peptide, with a covalently bonded DOTA bifunctional chelator. DOTA-TATE can be reacted with the radionuclides gallium-68 (T1/2 = 68 min), lutetium-177 (T1/2 = 6.65 d) and copper-64 (T1/2 = 12.7 h) to form radiopharmaceuticals for positron emission tomography (PET) imaging or radionuclide therapy. DOTA-TATE is a compound containing tyrosine3-octreotate, an SSR agonist, and the bifunctional chelator DOTA (tetraxetan). SSRs are found with high density in numerous malignancies, including CNS, breast, lung, and lymphatics. |
|
| DC74907 |
Bimakalim |
Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs |
|
| DC74908 |
CRD-733 |
CRD-733 is a PDE9A inhibitor. CRD-733 Reverses Pressure Overload-Induced Heart Failure. CRD-733 improves key hallmarks of HF including LV hypertrophy, LV dysfunction, left atrial dilation, and pulmonary edema after pressure overload in the mouse transverse aortic constriction HF model. |
|
| DC74909 |
KHS-101 free base |
KHS-101 is a selective inducer of neuronal differentiation. KHS101 induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM). KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice. KHS101 promoted tumor cell death in diverse GBM cell models. KHS101 exerted cytotoxic effects by disrupting the mitochondrial chaperone heat shock protein family D member 1 (HSPD1). In GBM cells, KHS101 promoted aggregation of proteins regulating mitochondrial integrity and energy metabolism. |
|
| DC74910 |
TRX-0237 mesylate |
Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacological activity on brain structure and function as both monotherapy and as an add-on to symptomatic treatment in certain patients with Alzheimer’s disease. |
|
| DC74911 |
Gramicidin S TFA |
Gramicidin S (GS), also known as Gramicidin soviet, is an antibiotic. GS reduces the cell number of planktonic cells within 20-40 min at a concentration of 40-80 μg/mL. GS kills the cells of pre-grown biofilms at concentrations of 100-200 μg/mL, such that no re-growth is possible. The translocation of the peptide into the cell interior and its complexation with intracellular nucleotides, including the alarmon ppGpp, can explain its anti-biofilm effect. The successful treatment of persistently infected root canals of two volunteers confirms the high effectiveness of GS. The broad GS activity towards resistant, biofilm-forming E. faecalis suggests its applications for approval in root canal medication. |
|
| DC74912 |
Tirofiban HCl hydrate |
Tirofiban is an antiplatelet drug. It belongs to a class of antiplatelet named glycoprotein IIb/IIIa inhibitors. Tirofiban is the first drug candidate whose origins can be traced to a pharmacophore-based virtual screening lead. Tirofiban is indicated to reduce the rate of thrombotic cardiovascular events (combined endpoint of death, myocardial infarction, or refractory ischemia/repeat cardiac procedure) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). |
|
| DC74913 |
BMS-223131 |
BMS-223131 is a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels. BMS-223131 effectively reduced stress-induced colonic motility and visceral nociception supporting the potential utility of maxi-K channel openers for the treatment of bowel disorders involving dysfunctional motility and visceral sensitivity. |
|
| DC74914 |
Terbutaline |
Terbutaline is a β2 adrenergic receptor agonist, used as a "reliever" inhaler in the management of asthma symptoms and as a tocolytic (anti-contraction medication) to delay preterm labor for up to 48 hours. This time can then be used to administer steroid injections to the mother which help fetal lung maturity and reduce complications of prematurity. It should not be used to prevent preterm labor or delay labor more than 48–72 hours. |
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