| DC10082 |
ISCK03
Featured
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ISCK03 is a cell-permeable inhibitor of SCF-mediated c-kit activation, completely blocking phosphorylation of c-kit in human melanoma cells at a concentration between 1 and 5 µM. |
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| DCAPI1264 |
Isepamicin |
Isepamicin |
|
| DC8427 |
Isepamicin Sulphate |
Isepamicin Sulphate is an aminoglycoside antibiotic, which inhibits bacterial protein synthesis by targeting the bacterial 30S ribosomal subunit. |
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| DC21153 |
ISO-66 |
ISO-66 is a novel, highly stable, small-molecule MIF inhibitor that inhibits MIF tautomerase activity with IC50 of 1.4 uM. |
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| DC22118 |
ISO-92 |
ISO-92 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity with IC50 of 0.55 uM.. |
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| DC12146 |
Isoastragaloside IV |
Isoastragaloside IV is a triterpene oligoglycoside isolated from Astragali Radix. |
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| DC23058 |
Corylifolinin(Isobavachalcone)
Featured
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Isobavachalcone is a natural chalcone first isolated from P. corylifolia that displays antibacterial, antifungal, anticancer, anti-reverse transcriptase, antitubercular, and antioxidant activities in various research models. |
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| DC21133 |
Isobutyl-deoxynyboquinone |
Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1), produces ROS, and induces cytotoxicity in cancer cells in an NQO1-dependent manner. |
|
| DC20010 |
Isocarboxazid |
Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC50 of 4.8 μM for rat brain monoamine oxidase in vitro. |
|
| DC12071 |
Isocryptotanshinone |
Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B. |
|
| DC23768 |
Isoginkgetin |
Isoginkgetin (Iso-ginkgetin. |
|
| DCAPI1396 |
Isoliquiritigenin |
Isoliquiritigenin |
|
| DC23110 |
Isoliquiritin
Featured
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Isoliquiritin has significant antidepressant-like, antifungal and anti-cancer activities. It induces apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells and inhibit the p53-dependent pathway and showed crosst |
|
| DC22328 |
Isomaltose
Featured
|
Isomaltose is a glucose disaccharide with an α-(1→6) linkage, as opposed to the α-(1→4) linkage found in maltose. |
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| DC22585 |
Isomangiferin |
Isomangiferin is the major tetracyclic oxindole alkaloid components of Uncaira species, inhibits NMDA receptor with IC50 of 43.2 uM, also blocks calcium channel. |
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| DC21154 |
Isomigrastatin |
Isomigrastatin (iso-Migrastatin) is an analogue of migrastatin that shows potent antiproliferative effect on tumor cell lines and selectively inhibits translation. |
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| DCAPI1242 |
Isoniazid(Tubizid)
Featured
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Isoniazid is an antibacterial agent used primarily as a tuberculostatic.Target: AntibacterialIsoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG [1]. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824 [2, 3]. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing [4]. |
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| DC20215 |
Isonicotinic acid; Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid |
Isonicotinic acid is a metabolite of isoniazid. It is an isomer of nicotinic acid. |
|
| DC8996 |
Isoprenaline HCl |
Isoprenaline Hydrochloride is a non-selective beta-adrenergic agonist and structurally similar to adrenaline. |
|
| DC12147 |
Isoquercitrin (Isoquercitroside; Isoquercetin) |
Isoquercitrin is an effective antioxidant and an eosinophilic inflammation suppressor. |
|
| DC23107 |
ISOQUERCITRIN
Featured
|
Isoquercitrin is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation; it is also a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. |
|
| DC23018 |
Isoscopoletin
Featured
|
Isoscopoletin possesses inhibitory activity against hepatitis B virus (HBV) replication; it also shows substantial inhibition against multi-drug resistant CEM/ADR5000 cells and human CCRF-CEM leukaemia cells, with the IC50 value is 1.6 and 4.0 microM, res |
|
| DC23053 |
Isosilybin
Featured
|
Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities.It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lac |
|
| DC8960 |
Isosorbide 5-mononitrate |
Isosorbide mononitrate(Isosorbide-5-mononitrate) is a nitrate-class compound used for angina pectoris; acts by dilating the blood vessels so as to reduce the blood pressure. |
|
| DC9824 |
Isosteviol
Featured
|
Isosteviol is a derivative of stevioside, a constituent of Stevia rebaudiana, which is commonly used as a noncaloric sugar substitute in Japan and Brazil. |
|
| DC12069 |
Isotanshinone I |
Isotanshinone I has inhibitory activity against α-glucosidase and formation of AGE, with IC50s of 1.13, 0.432 μM for α-glucosidase and AGE, respectively. |
|
| DC12066 |
Isotanshinone IIA |
Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. |
|
| DC21434 |
Isothiafludine |
Isothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM. |
|
| DC9039 |
Isotretinoin |
Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. |
|
| DC23095 |
ISOVITEXIN
Featured
|
Isovitexin, a food phytochemical contained in dietary rice products, it exhibits in vivo α-glucosidase inhibition, it possesses antihyperglycemic, neuroprotective, anti-inflammatory and anti-oxidant activities. Isovitexin inhibited xanthine oxidase with a |
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