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Cat. No. Product Name Field of Application Chemical Structure
DC5107 SB-715992 (Ispinesib) Featured Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively.
DC8772 Isradipine Featured Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.
DC7431 ISRIB Featured ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM.
DC12393 iST2-1 iST2-1 is a first-in-class, in vivo active ST2 (suppression of tumorigenicity 2) inhibitor with IC50 of 56.14 and 54.62 uM in AlphaLISA and the HEK-Blue IL-33 assay, respectively.
DC22333 iST2-2 Featured iST2-2 is a novel ST2 (suppression of tumorigenicity 2) inhibitor active in vivo.
DC7151 Istaroxime(PST2744) Istaroxime(PST2744) is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase).
DC7845 Istaroxime hydrochloride(PST2744) Istaroxime(PST2744) is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase).
DCAPI1080 Istradefylline (KW-6002) Featured Istradefylline(KW6002) is a very potent, selective and orally active adenosine A2A receptor antagonist(Ki=2.2 nM) in experimental models of Parkinson's disease.
DC8304 Isoxazole 9(ISX9) Featured ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitro and in vivo.
DC10898 Protein kinase inhibitor 1 Featured It is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
DC10768 IT 901 Featured IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro.
DC10283 IT1t dihydrochloride Featured IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM.
DC10306 IT1t IT1t is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM.
DC12378 Itacitinib(INCB039110) Featured Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis.
DC8028 ITD-1 Featured ITD-1 is a novel and highly selective TGFβ pathway inhibitor. ITD-1 molecule turns stem cells into heart cells.
DC23662 ITI214 free base Featured ITI-214 is a potent, selective phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms.
DC23687 ITI214 ITI-214 is a potent, selective, orally active phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms.
DCAPI1366 Itraconazole (Sporanox) Itraconazole (Sporanox)
DC10220 ITSA-1 (ITSA1) Featured ITSA-1 (ITSA1) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors.
DC21156 ITX-5061 ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels.
DC21157 ITX-5061 hydrochloride Featured ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels.
DC22795 ITZ-1 ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation.
DC26005 IU1 Featured IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats.
DC23797 IU1-47 Featured IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons.
DC3153 Ivabradine hydrochloride Featured Ivabradine, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.
DC4128 Ivacaftor (VX-770) Featured Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
DC24117 Ivacaftor benzenesulfonate Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM.
DC24116 Ivacaftor hydrate Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM.
DC7434 IWP-L6 Featured IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM.
DC5028 IWP-2 Featured IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses.

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