| DC5107 |
SB-715992 (Ispinesib)
Featured
|
Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively. |
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|
| DC8772 |
Isradipine
Featured
|
Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM. |
|
| DC7431 |
ISRIB
Featured
|
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM. |
|
| DC12393 |
iST2-1 |
iST2-1 is a first-in-class, in vivo active ST2 (suppression of tumorigenicity 2) inhibitor with IC50 of 56.14 and 54.62 uM in AlphaLISA and the HEK-Blue IL-33 assay, respectively. |
|
| DC22333 |
iST2-2
Featured
|
iST2-2 is a novel ST2 (suppression of tumorigenicity 2) inhibitor active in vivo. |
|
| DC7151 |
Istaroxime(PST2744) |
Istaroxime(PST2744) is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). |
|
| DC7845 |
Istaroxime hydrochloride(PST2744) |
Istaroxime(PST2744) is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). |
|
| DCAPI1080 |
Istradefylline (KW-6002)
Featured
|
Istradefylline(KW6002) is a very potent, selective and orally active adenosine A2A receptor antagonist(Ki=2.2 nM) in experimental models of Parkinson's disease. |
|
| DC8304 |
Isoxazole 9(ISX9)
Featured
|
ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitro and in vivo. |
|
| DC10898 |
Protein kinase inhibitor 1
Featured
|
It is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM. |
|
| DC10768 |
IT 901
Featured
|
IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro. |
|
| DC10283 |
IT1t dihydrochloride
Featured
|
IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. |
|
| DC10306 |
IT1t |
IT1t is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. |
|
| DC12378 |
Itacitinib(INCB039110)
Featured
|
Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis. |
|
| DC8028 |
ITD-1
Featured
|
ITD-1 is a novel and highly selective TGFβ pathway inhibitor. ITD-1 molecule turns stem cells into heart cells. |
|
| DC23662 |
ITI214 free base
Featured
|
ITI-214 is a potent, selective phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms. |
|
| DC23687 |
ITI214 |
ITI-214 is a potent, selective, orally active phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms. |
|
| DCAPI1366 |
Itraconazole (Sporanox) |
Itraconazole (Sporanox) |
|
| DC10220 |
ITSA-1 (ITSA1)
Featured
|
ITSA-1 (ITSA1) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. |
|
| DC21156 |
ITX-5061 |
ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels. |
|
| DC21157 |
ITX-5061 hydrochloride
Featured
|
ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels. |
|
| DC22795 |
ITZ-1 |
ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation. |
|
| DC26005 |
IU1
Featured
|
IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats. |
|
| DC23797 |
IU1-47
Featured
|
IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons. |
|
| DC3153 |
Ivabradine hydrochloride
Featured
|
Ivabradine, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. |
|
| DC4128 |
Ivacaftor (VX-770)
Featured
|
Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
|
| DC24117 |
Ivacaftor benzenesulfonate |
Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. |
|
| DC24116 |
Ivacaftor hydrate |
Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. |
|
| DC7434 |
IWP-L6
Featured
|
IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM. |
|
| DC5028 |
IWP-2
Featured
|
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. |
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