DC9979 |
PRX-08066
Featured
|
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that causes selective vasodilation of pulmonary arteries. |
|
DC21536 |
PS210
Featured
|
PS 210 is a potent, specific activator of PDK1 that target the PIF-binding pocket of PDK1, does not alter the activity of any of the 121 kinases (S6K, PKB/Akt or GSK3).. |
|
DC21537 |
PS 423 |
PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210. |
|
DC23286 |
PS1 |
PS1 is a potent inhibitor of IAP family with IC50 of 36/96/33 nM for c-IAP1/c-IAP2/XIAP respectively.. |
|
DC21468 |
PS10 |
PS10 (PDK inhibitor PS10) is a novel potent and highly selective pyruvate dehydrogenase kinase (PDK) inhibitor. |
|
DC7969 |
PS-1145
Featured
|
PS-1145 has been shown to be an IKK (IKB kinase) inhibitor. |
|
DC23838 |
PS-432 |
PS-432 is an allosteric inhibitor of PKCι and PKCζ with IC50 of 16.9 and 18.5 uM, respectively. |
|
DC22313 |
PS48
Featured
|
PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. |
|
DC21538 |
PSB-12379 disodium |
PSB-12379 is an α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 9.03/2.21 nM for rat/human recombinant eN. |
|
DC21539 |
PSB-12431 |
PSB-12431 is an α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 9.2 nM for rat recombinant eN. |
|
DC21540 |
PSB-12553 |
PSB-12553 is an α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 9.5 nM for rat recombinant eN. |
|
DCAPI1432 |
Mupirocin |
Pseudomonic Acid, also known as mupirocin, is an antibiotic isolated from Pseudomonas fluorescens which strongly inhibits protein and RNA synthesis. Inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit isole |
|
DC4121 |
PSI6130
Featured
|
PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor. PSI-6130(R 1656) is useful for Antiviral agents. |
|
DC6309 |
PSI6206
Featured
|
PSI-6206 is a selective inhibitor of hepatitis C virus (HCV). |
|
DC10162 |
PSI-7409 |
PSI-7409 is the active 5′-triphosphate metabolite of PSI-7851. PSI-7851 is a selective and highly active nucleotide analog inhibitor of HCV. |
|
DC6308 |
Sofosbuvir(PSI7977,GS-7977)
Featured
|
PSI-7977 is an investigational nucleotide analog currently in Phase 2 for treatment of chronic HCV infection. |
|
DC12162 |
PSMA-617
Featured
|
PSMA-617 is a high potent prostate-specific membrane antigen (PSMA) inhibitor, with a Ki of 0.37 nM. |
|
DC7893 |
PSN632408 |
PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 uM, respectively. |
|
DC23683 |
PSN-GK1 |
PSN-GK1 is a potent, orally available Glucokinase (GK) activator with EC50 of 130 nM at 5 mM glucose (4.3-fold). |
|
DC23654 |
Psora-4
Featured
|
Psora-4 is a potent and selective Kv1.3 potassium channel blocker with EC50 of 3 nM. |
|
DC23199 |
Psoralidin
Featured
|
Psoralidin possesses potent antidepressant-like, anti-inflammatory, anticancer and chemopreventive properties. Psoralidin is a dual inhibitor of COX-2 and 5-LOX |
|
DC20513 |
PST-1 |
PST-1 is a photoswitchable inhibitor of microtubule with EC50 of 0.5 uM under 390 nm irradiation in the MDA-MB-231 human breast cancer cell lines. |
|
DC20514 |
PST-1P |
PST-1P is a photoswitchable inhibitor of microtubule with EC50 of 0.7 uM under 390 nm irradiation in the MDA-MB-231 human breast cancer cell lines. |
|
DC10464 |
PT2385
Featured
|
PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. |
|
DC9811 |
PT2399
Featured
|
PT2399(PT=2399) is a novel HIF2α Antagonist. |
|
DC8654 |
PTACH (NCH-51)
Featured
|
PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM. |
|
DC7552 |
PTC-028
Featured
|
PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification |
|
DC2005 |
PTC124 (Ataluren)
Featured
|
PTC124 (Ataluren) is a potent nonsense mutation inhibitor with EC50 of ~0.1 μM. |
|
DC7485 |
PTC-209
Featured
|
PTC-209 is a specific inhibitor for BMI-1 with IC50 of 0.5 uM in in both GEMS reporter and ELISA assays. |
|
DC8495 |
PTC-209 hydrobromide
Featured
|
PTC-209 is a specific inhibitor for BMI-1 with IC50 of 0.5 uM in in both GEMS reporter and ELISA assays. |
|