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ANTISAUVAGINE-30

  Cat. No.:  DC20309   Featured
Chemical Structure
220673-95-0
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist with Ki of 1.4 nM, 100-fold selectiivity over CRF1.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 220673-95-0
Chemical Name: ANTISAUVAGINE-30
Synonyms: ANTISAUVAGINE-30;D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2;(D-PHE11,HIS12)-SAUVAGINE (11-40);(D-PHE11,HIS12)-SAUVAGINE (11-40) TRIFLUOROACETATE SALT;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THE-ILE-OH;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2;M.W. 3650.29 C161H274N48O46S;(D-Phe??00His??)-Sauvagine(11-40);(D-Phe11,His12)-Sauvagine (11-40), Antisauvagine-30;11-D-Phenylalanine-12-L-histidine-11-40-sauvagin
SMILES: NCCCCCC(NCC(NCC(NCC(NCC(NCC(NCC(NCC(NCC(NCC(NCC(NCC(NCC(NCC(NCC(NCCC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Formula: C161H273N47O47S
M.Wt: 3651.24201999998
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF2β and rat CRF1 receptors, respectively[1].
Target: Kd: 1.4 nM (mouse CRF2β) ;Kd: 153.6 nM (rat CRF1)[1]
References: [1]. O Brauns, et al. Pharmacological and chemical properties of astressin, antisauvagine-30 and alpha-helCRF: significance for behavioral experiments. Neuropharmacology. 2001 Sep;41(4):507-16. [2]. Farahnaz Sananbenesi, et al. Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J Neurosci
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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