| DC12234 |
Retinyl palmitate (Vitamin A palmitate; Retinol palmitate) |
Retinyl palmitate is an ester of Retinol and is the major form of vitamin A found in the epidermis. Retinyl palmitate has been widely used in pharmaceutical and cosmetic formulations. |
|
| DC23293 |
RETRA hydrobromide |
RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft. |
|
| DC23287 |
RETRA hydrochloride |
RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft. |
|
| DC23312 |
RETRA |
RETRA is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft. |
|
| DC20531 |
Retro 1 |
Retro 1 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface. |
|
| DC20532 |
Retro 2 |
Retro 2 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface. |
|
| DC20533 |
Rev1-IN-5 |
Rev1-IN-5 is a small molecule inhibitor of the C-terminal domain of Rev1 and the Rev1-interacting region protein-protein interaction (Rev1-CT/RIR PPI) with IC50 of 2.5 uM. |
|
| DC21616 |
Revaprazan |
Revaprazan (SB-641257. |
|
| DC21617 |
Revaprazan hydrochloride |
Revaprazan (SB-641257. |
|
| DC7260 |
Reversine
Featured
|
Reversine, a small synthetic purine analogue (2,6-disubstituted purine), is a potent inhibitior of Aurora A/B/C with IC50s of 150-500 nM. |
|
| DC21696 |
Revexepride |
Revexepride (SSP 002358. |
|
| DC7584 |
RG108
Featured
|
RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM, does not cause trapping of covalent enzymes. |
|
| DC9857 |
RG-13022
Featured
|
RG-13022 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 1 µM in HT-22 cells. |
|
| DC10367 |
RG14620
Featured
|
RG14620 is an epidermal growth factor receptor (EGFR) inhibitor, with IC50 values of 3 μM for HER 14 colony formation and 1 pM for HER 14 DNA synthesis. |
|
| DC7795 |
RG2833 (RGFP109)
Featured
|
RG2833 is a brain-penetrant inhibitor of HDAC with IC50 values of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. |
|
| DC7721 |
RG7090（Basimglurant）
Featured
|
RG7090(CTEP Derivative,Basimglurant, RO4917523) is a negative modulator of metabotropic glutamate receptor subtype 5 (mGluR5; GRM5). |
|
| DC8865 |
RG-7112
Featured
|
RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor. |
|
| DC7821 |
Idasanutlin (RG-7388)
Featured
|
RG7388 is an oral, selective, small molecule MDM2 antagonist that inhibits binding of MDM2 to p53. |
|
| DC10191 |
RG7800 |
RG7800 a small molecule SMN2 splicing modifier to enter human clinical trials to treat spinal muscular atrophy. |
|
| DC20005 |
RG7834 (RO 7020322)
Featured
|
RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells. |
|
| DC7768 |
RGB286638
Featured
|
RGB-286638 is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6. |
|
| DC7263 |
RGFP 966
Featured
|
RGFP966 is specific inhibitor of HDAC3, with an IC50 of 0.08 μM and no effective inhibition of any other HDAC at concentrations up to 15 μM. |
|
| DC10719 |
RGX-104
Featured
|
RGX-104 is an orally bioavailable agonist of the nuclear receptor liver X receptor beta (LXRbeta; NR1H2; LXR-b), with potential immunomodulating and antineoplastic activities. |
|
| DC21564 |
RH01386 |
RH01386 is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. |
|
| DC21565 |
RH01687
Featured
|
RH01687 is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. |
|
| DC23734 |
Rheb inhibitor NR1
Featured
|
Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK. |
|
| DCAPI1188 |
Rhein(Monorhein) |
Rhein(Monorhein) |
|
| DCAPI1221 |
Rheochrysidin (Physcione) |
Rheochrysidin (Physcione) |
|
| DC8185 |
Verosudil(AR-12286) |
Rho-kinase (ROCK) inhibitor |
|
| DC23186 |
Rhosin |
Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG. |
|
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