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Cat. No. Product Name Field of Application Chemical Structure
DC10404 BIA 10-2474 Featured BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions.
DCAPI1112 BIBR 953(Dabigatran) Featured BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate.
DC1010 BIBR-1048 (Dabigatran etexilate) Featured BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors.
DC10890 Bictegravir Featured Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
DC7086 BIIB021(CNF2024) Featured BIIB021(CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively.
DC8882 Bitopertin Featured Bitopertin, also known as RG1678, is a potent and selective inhibitor of GlyT1 with an EC50 of 30nM.
DC5154 BKM120 (NVP-BKM120, Buparlisib) Featured BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ.
DC4196 Bleomycin Sulfate Featured Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.
DC10530 BLU-285 (Avapritinib) Featured BLU-285 is a potent and selective exon 17 mutant KIT kinase inhibitor with IC50 of 0.27 nM for KIT D816V.
DC10092 BLU554(Fisogatinib) Featured BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor.
DC11479 BLU-667 (Pralsetinib) Featured BLU-667 (Pralsetinib) is a highly potent, selective, next generation RET inhibitor with IC50 of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion.
DC8280 BLU-9931 Featured BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM).
DC8103 BLZ-945 Featured BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; >3200-fold higher than its affinity for other kinases.
DC11761 BMS-816336 A novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM.
DC3105 BMS-599626 (AC480) Featured BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively.
DC9252 BMS-687453 Featured BMS687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist, with an EC50 of 10 nM for human PPARα and ∼410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays.
DC9700 BMS-707035 Featured BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity.
DC3114 Avagacestat (BMS-708163) Featured BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively.
DC3126 BMS754807 Featured BMS-754807 is a potent and reversible inhibitor of IGF-1R/IR family kinases, inhibits IGF-1R, IR, Met, TrkA and TrkB with IC50 of 1.8 nM, 1.7 nM, 5.6 nM, 7.4 nM and 4.1 nM, respectively.
DC9861 BMS-779788(XL-652) Featured BMS-779788(XL652) is a novel small-molecule modulator of the Liver X Receptor (LXR), a nuclear hormone receptor implicated in a variety of cardiovascular and metabolic disorders.
DC9638 BMS-794833 BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7/15 nM; also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378.
DC11862 BMS-906024 BMS-906024 is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively.
DC4175 BMS-911543 Featured BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, approximately 350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively.
DC10459 BMS-986020 Featured BMS-986020 is an LPA1 antagonist.
DC11923 BMS-986120 Featured BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.
DC11819 BMS-986142 Featured BMS-986142 is a potent, selective, and reversible BTK (Bruton’s tyrosine kinase) inhibitor (BTK IC₅₀ = 0.5nM; human WB IC₅₀ = 90 nM).
DC10609 BMS-986158 Featured BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins.
DC12030 BMS-986195 Featured BMS-986195 is a potent, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK).
DC10131 BMS-986205(Linrodostat) Featured BMS-986205 is an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic activity, alone and in combination with nivolumab in advanced cancers in a phase 1/2a trial
DC5077 Boceprevir(EBP 520; SCH 503034 ) Featured Boceprevir(EBP 520; SCH 503034 ) is useful for Anti HCV.

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