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Tyrosine Kinase

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Cat. No. Product Name Field of Application Chemical Structure
DC7056 AMG-208 Featured AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.
DC8845 AMG337 Featured AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays.
DC7001 AMG-47a Featured AMG-47a is a potent inhibitor of Lck and T cell proliferation; exhibits anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice.
DC7324 Amuvatinib (MP-470) Featured Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively.
DC8029 ANA-12 Featured ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.
DC1020 Ponatinib (AP24534) Featured AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.
DC4101 Apatinib Mesylate Featured Apatinib (YN968D1) is an orally bioavailable, selective VEGFR2 inhibitor with IC50 of 1 nM.
DC10975 ARQ-531 Featured ARQ-531 is a potent, reversible, orally available inhibitor of both wild type and C481S-mutant BTK kinase with IC50 of 0.85 and 0.39 nM,
DC8486 Varlitinib(ARRY-334543) ARRY-334543 is a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases.
DC7359 Asp-3026 Featured ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM.
DC7360 AST-1306 AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
DC10921 ATH686 Featured ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase.
DC8253 AV-412(MP-412) AV-412(MP-412) is a potent dual inhibitor of EGFR and ErbB2(IC50=19 nM) tyrosine kinases, including the mutant EGFR(L858R IC50=0.51 nM, T790M IC50=0.79 nM); inhibits autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively.
DC10009 Avitinib free base Featured Avitinib is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity.
DC10008 Avitinib maleate Featured Avitinib is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity.
DC5014 AVL-292 Featured AVL-292 is a covalent, highly selective, orally active small molecule inhibitor of Btk currently being evaluated in a Phase 1b clinical trial in relapsed.
DCAPI1524 Axitinib Featured Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. This compound also inhibits VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-β and c-KIT with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib is studied as an ant
DC7746 AZ191 Featured AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.
DC8052 AZ5104 Featured AZ5104 is an active circulating metabolite of AZD9291.
DC7799 AZD2932 Featured AZD-2932 is a high affinity inhibitor of VEFGR-2 and PDGFR.
DC8472 AZD-3759 Featured AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity.
DC1075 AZD4547 Featured AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3 with IC50 of of 0.2 nM, 2.5 nM, and 1.8 nM, respectively.
DC12490 AZD7507 Featured AZD7507 (AZD-7507) is a potent, selective, orally available CSF-1R (c-FMS) with IC50 of 32 nM.
DC7006 AZD-9291(Osimertinib) Featured AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM).
DC8462 AZD-9291 mesylate (Osimertinib,Mereletinib) Featured AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM).
DC10112 AZD9362 AZD-9362 is dual IGF-IR/InsR inhibitor.
DC2013 Bafetinib (INNO-406) Featured Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM and 19 nM, respectively.
DC9632 BAY 61-3606 (dihydrochloride) Featured BAY 61-3606 2Hcl is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
DC10660 BAY 61-3606 free base Featured BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
DC10058 BBT594 BBT594 (NVP-BBT594), is potent and selective inhibitor of RET and JAK2.

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