Cat. No. | Product name | CAS No. |
DC10008 |
Avitinib maleate
Featured
Avitinib is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. |
1557268-88-8 |
DC5014 |
AVL-292
Featured
AVL-292 is a covalent, highly selective, orally active small molecule inhibitor of Btk currently being evaluated in a Phase 1b clinical trial in relapsed. |
1202757-89-8 |
DCAPI1524 |
Axitinib
Featured
Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. This compound also inhibits VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-β and c-KIT with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib is studied as an ant |
319460-85-0 |
DC7746 |
AZ191
Featured
AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively. |
1594092-37-1 |
DC8052 |
AZ5104
Featured
AZ5104 is an active circulating metabolite of AZD9291. |
1421373-98-9 |
DC7799 |
AZD2932
Featured
AZD-2932 is a high affinity inhibitor of VEFGR-2 and PDGFR. |
883986-34-3 |
DC8472 |
AZD-3759
Featured
AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. |
1626387-80-1 |
DC1075 |
AZD4547
Featured
AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3 with IC50 of of 0.2 nM, 2.5 nM, and 1.8 nM, respectively. |
1035270-39-3 |
DC12490 |
AZD7507
Featured
AZD7507 (AZD-7507) is a potent, selective, orally available CSF-1R (c-FMS) with IC50 of 32 nM. |
1041852-85-0 |
DC7006 |
AZD-9291(Osimertinib)
Featured
AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM). |
1421373-65-0 |
DC8462 |
AZD-9291 mesylate (Osimertinib,Mereletinib)
Featured
AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM). |
1421373-66-1 |
DC10112 |
AZD9362
AZD-9362 is dual IGF-IR/InsR inhibitor. |
1905412-80-7 |
DC2013 |
Bafetinib (INNO-406)
Featured
Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM and 19 nM, respectively. |
859212-16-1 |
DC9632 |
BAY 61-3606 (dihydrochloride)
Featured
BAY 61-3606 2Hcl is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
648903-57-5 |
DC10660 |
BAY 61-3606 free base
Featured
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
732983-37-8 |
DC10058 |
BBT594
BBT594 (NVP-BBT594), is potent and selective inhibitor of RET and JAK2. |
882405-89-2 |
DC10448 |
Belizatinib(TSR-011)
Featured
Belizatinib(TSR-011) is an orally available inhibitor of both the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the tropomyosin-related kinases (TRK) TRKA, TRKB, and TRKC, with potential antineoplastic activity. |
1357920-84-3 |
DC9956 |
BFH772
Featured
BFH772 is a potent oral VEGFR2 inhibitor, which is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM. |
890128-81-1 |
DC10335 |
BGB-3111
BGB-3111 is a potent, selective and orally available Bruton's tyrosine kinase (Btk) inhibitor. |
1633350-06-7 |
DC5194 |
NVP-BGJ398(Infigratinib)
Featured
BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2. |
872511-34-7 |
DC11760 |
BI 885578
BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively. |
|
DC10530 |
BLU-285 (Avapritinib)
Featured
BLU-285 is a potent and selective exon 17 mutant KIT kinase inhibitor with IC50 of 0.27 nM for KIT D816V. |
1703793-34-3 |