Cat. No. | Product name | CAS No. |
DC10092 |
BLU554(Fisogatinib)
Featured
BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor. |
1707289-21-1 |
DC11479 |
BLU-667 (Pralsetinib)
Featured
BLU-667 (Pralsetinib) is a highly potent, selective, next generation RET inhibitor with IC50 of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion. |
2097132-94-8 |
DC8280 |
BLU-9931
Featured
BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM). |
1538604-68-0 |
DC8103 |
BLZ-945
Featured
BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; >3200-fold higher than its affinity for other kinases. |
953769-46-5 |
DC8515 |
BMS-2
BMS-2 is a potent MET kinase inhibitor with an IC50 value of 1.8nM. It also possesses potent inhibitory activity against Flt-3 and VEGFR-2 kinases, IC50 values of 4nM and 27nM respectively. |
888719-03-7 |
DC5037 |
BMS-536924
Featured
BMS-536924 is an ATP-competitive IGF-1R inhibitor with IC50 of 100 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2. |
468740-43-4 |
DC3105 |
BMS-599626 (AC480)
Featured
BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively. |
714971-09-2 |
DC3126 |
BMS754807
Featured
BMS-754807 is a potent and reversible inhibitor of IGF-1R/IR family kinases, inhibits IGF-1R, IR, Met, TrkA and TrkB with IC50 of 1.8 nM, 1.7 nM, 5.6 nM, 7.4 nM and 4.1 nM, respectively. |
1001350-96-4 |
DC9638 |
BMS-794833
BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7/15 nM; also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. |
1174046-72-0 |
DC11819 |
BMS-986142
Featured
BMS-986142 is a potent, selective, and reversible BTK (Bruton’s tyrosine kinase) inhibitor (BTK IC₅₀ = 0.5nM; human WB IC₅₀ = 90 nM). |
1643368-58-4 |
DC12030 |
BMS-986195
Featured
BMS-986195 is a potent, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK). |
1912445-55-6 |
DC2019 |
Brivanib (bms-540215)
Featured
Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively. |
649735-46-6 |
DC9266 |
Cabozantinib S-malate
Featured
Cabozantinib S-malate (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. |
1140909-48-3 |
DC3138 |
Canertinib dihydrochloride
Featured
Canertinib dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. |
289499-45-2 |
DC8482 |
CAY10415(MSDC-0160)
Featured
CAY10415 is a potent, antidiabetic drug of the TZD structural class. |
146062-49-9 |
DC3170 |
Cediranib
Featured
Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM. |
288383-20-0 |
DC8138 |
CEP-28122
Featured
CEP-28122 is a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. |
1022958-60-6 |
DC8009 |
CEP-37440
Featured
CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma). |
1391712-60-9 |
DC10337 |
CEP-40783
Featured
CEP-40783 is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively. |
1437321-24-8 |
DC7380 |
CGI-1746
Featured
CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation. |
910232-84-7 |
DC8418 |
CH5183284 (Debio-1347)
Featured
CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1. |
1265229-25-1 |
DC7383 |
CH5424802(Alectinib)
Featured
CH5424802(AF 802; Alectinib) is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. |
1256580-46-7 |