TL13-22

  Cat. No.:  DC40846   Featured
Chemical Structure
2229036-65-9
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More than 5000 active chemicals with high quality for research!
Field of application
TL13-22 is a negative control for TL13-12 and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells.
Cas No.: 2229036-65-9
Chemical Name: Chembl4217930
Synonyms: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide;Chembl4217930;TL13-22
SMILES: ClC1C=NC(=NC=1NC1C=CC=CC=1S(C(C)C)(=O)=O)NC1C=CC(=CC=1OC)N1CCN(CCOCCOCCNC(CNC2=CC=CC3=C2C(N(C3=O)C2C(NCCC2)=O)=O)=O)CC1
Formula: C45H55ClN10O9S
M.Wt: 947.497807741165
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
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MSDS_23859_DC40846_2229036-65-9
COA
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Cat. No. Product name Field of application
DC45792 TPX-0131 TPX-0131 is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK (IC50 of 1.4 nM) and ALK-resistant mutation, e.g. G1202R (IC50 of 0.3 nM), L1196M (IC50 of 0.3 nM). TPX-0131 has strong antitumor activities.
DC40846 TL13-22 TL13-22 is a negative control for TL13-12 and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells.
DC7451 LDN-193189 HCl LDN193189 HCl is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
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