Cas No.: | 51-21-8 |
SMILES: | FC1C(=O)NC(=O)NC=1 |
Formula: | C4H3FN2O2 |
M.Wt: | 130.08 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | 5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.5-Fluorouracil is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-Fluorouracil leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis. |