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Atracurium besylate

  Cat. No.:  DCAPI1288   Featured
Chemical Structure
64228-81-5
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Field of application
Atracurium besylate is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 64228-81-5
Chemical Name: Atracurium Besylate
Synonyms: Atracurium Besylate;ATRACURIUM BESILATE;BW-33A;2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium dibenzenesulfonate;BW-33A, Tracrium, 2,2μ-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate;51W-89：Nimbex;Atraeurium Besylate;Atracurium;Atracurium Besilete;2,2’-[1,5-Pentanediylbis[oxy(3-oxcr3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate;2,2′-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate;Tracrium
SMILES: COC1C(OC)=CC(=CC=1)CC2C3C(=CC(OC)=C(OC)C=3)C[N+](CCC(=O)OCCCCCOC(=O)CC[N+]4(C)C(CC5C=C(OC)C(OC)=CC=5)C6C(=CC(OC)=C(OC)C=6)CC4)(C)C2
Formula: C53H72N2O12.2(C6H5O3S)
M.Wt: 1243.48
Purity: >99%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.Atracurium besylate is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Atracurium is classified as an intermediate-duration non-depolarizing neuromuscular-blocking agent [1]. A 14C radiolabeled metabolism study in cats confirmed the lack of hepatic or renal involvement in the metabolism of atracurium: radioactivity eliminated in bile and urine was predominantly from metabolites rather than the unchanged parent drug [2].
Target: nAChR
References: [1]. Fagerlund, M.J., M. Dabrowski, and L.I. Eriksson, Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology, 2009. 110(6): p. 1244-1252. [2]. Neill, E. and D. Chapple, Metabolic studies in the cat with atracurium: a neuromuscular blocking agent designed for non-enzymic inactivation at physiological pH. Xenobiotica, 1982. 12(3): p. 203-210.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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