SR 140333|SR140333;SR-140333

Cas No.:	153050-21-6
Chemical Name:	1-[2-[(3S)-3-(3,4-Dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride
Synonyms:	SR140333;SR-140333
SMILES:	[N+](CC[C@](C1=CC=C(Cl)C(Cl)=C1)1CCCN(C(CC2=CC=CC(OC(C)C)=C2)=O)C1)12CCC(C3=CC=CC=C3)(CC1)CC2.[Cl-]
Formula:	C₃₇H₄₅Cl₃N₂O₂
M.Wt:	656.12
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective, non-peptide NK1 receptor antagonist with Ki of 0.74 nM, IC50 of 1.6 nM; shows no effect in bioassays for NK2 and NK3 receptors; blocks substance P-induced release of acetylcholine from rat striatum, exerts highly potent antagonism toward substance P-induced hypotension in vivo, also blocks the activation of rat thalamic neurons after nociceptive stimulation.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47011	Elinzanetant	Elinzanetant is a neurokinin receptors antagonist used for the research of Schizophrenia.
DC46851	Imnopitant	Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) .
DC46850	SB 218795	SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.
DC42312	Hemokinin 1 (mouse)	Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.
DC42311	Neurokinin A TFA	Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.
DC42048	Biotin-Substance P	Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
DC41718	[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA	[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM.
DC41717	[Lys5,MeLeu9,Nle10]-NKA(4-10)	[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM.
DC41716	GR 64349 TFA	GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively.
DC41715	GR 94800 TFA	GR 94800 TFA is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively.