Cas No.: | 832115-62-5 |
Chemical Name: | N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide |
Synonyms: | N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide;Isoxazole 9;ISX 9;ISX-9;N-Cyclopropyl-5-(2-thienyl)-1,2-oxazole-3-carboxamide |
SMILES: | O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3 |
Formula: | C11H10N2O2S |
M.Wt: | 234.2743 |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | ISX-9 is a small molecule inducer of adult neural stem cell differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test. |