Mitapivat

  Cat. No.:  DC10568   Featured
Chemical Structure
1260075-17-9
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More than 5000 active chemicals with high quality for research!
Field of application
Mitapivat is an activator of pyruvate kinase isoenzyme M2 (PKM2),
Cas No.: 1260075-17-9
Chemical Name: N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide
Synonyms: N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide
SMILES: O=S(=O)(NC1C=CC(C(=O)N2CCN(CC3CC3)CC2)=CC=1)C1C=CC=C2C=1N=CC=C2
Formula: C24H26N4O3S
M.Wt: 450.553244113922
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Mitapivat is a potent human R-type pyruvate kinase (PKR) inhibitor; also shows potency for mutant PKR including R510Q PKR, R532W PKR, T384W PKR etc.
References: [1]. PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY. Patent WO/2012/151451A1
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC47090 Etavopivat Etavopivat is a potent, selective, orally bioavailable red blood cell (RBC) pyruvate kinase (PKR) activator. Etavopivat has potent antisickling effects.
DC10568 Mitapivat Mitapivat is an activator of pyruvate kinase isoenzyme M2 (PKM2),
DC8647 DASA-58 DASA-58 is a highly specific small molecule PKM2 activator. DASA-58 inhibits LPS-induced Hif-1a and IL-1b, as well as the expression of a range of other Hif-1a-dependent genes.
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