Quinine hemisulfate hydrate

  Cat. No.:  DC41268  
Chemical Structure
207671-44-1
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More than 5000 active chemicals with high quality for research!
Field of application
Quinine hemisulfate hydrate is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
Cas No.: 207671-44-1
Chemical Name: Quinine hemisulfate hydrate
SMILES: [H][C@@]1([C@H](O)C2=CC=NC3=C2C=C(OC)C=C3)C[C@H]4[C@@H](C=C)C[N@@]1CC4.OS(O)(=O)=O.O.[1/2]
Formula: C20H24N2O2.1/2H2O4S.H2O
M.Wt: 391.48
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC47407 Antimalarial agent 3 Antimalarial agent 3 shows nanomolar antiplasmodial activity (IC50 = 0.035 μM) and has a very high selectivity index with respect to mammalian cells.
DC47406 Antileishmanial agent-2 Antileishmanial agent-2 shows submicromolar antileishmanial activity (IC50 = 0.29 μM) and a very high selectivity index with respect to mammalian cells.
DC47405 Antimalarial agent 2 Antimalarial agent 2 is a novel orally efficacious antimalarials that suggests a fast in vitro killing profile.
DC47404 TCMDC-125431 TCMDC-125431 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.
DC47403 TCMDC-136230 TCMDC-136230 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.
DC47402 TCMDC-125457 TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.
DC47401 Antileishmanial agent-1 Antileishmanial agent-1 exhibits the activity against L. amazonensis promastigotes (IC50 = 15.52 μM) and intracellular amastigotes (IC50 = 4.10 μM).
DC47400 BRD5018 BRD5018 is an antimalarial agent.
DC47399 MMV674850 MMV674850 is potent against asexual stage parasites at 2.7 and 4.5 nM and preferentially targets early-stage gametocytes (early-stage gametocyte: IC50 4.5 ± 3.6 nM; late-stage gametocyte: IC50 28.7 ± 0.2 nM).
DC47398 MMV666810 MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).
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