SL 0101-1

  Cat. No.:  DC8239  
Chemical Structure
77307-50-7
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More than 5000 active chemicals with high quality for research!
Field of application
SL 0101-1 is a selective inhibitor of p90 Rsk (ribosomal S6 kinase) (IC50 = 89 nM for Rsk-2).
Cas No.: 77307-50-7
Chemical Name: 2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
Synonyms: SL-0101-1,SL0101-1,SL-0101,SL 0101,SL0101,SL0101 1
SMILES: C[C@H]1C(C([C@H](C(O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC=C(C=C4)O)O)OC(=O)C)OC(=O)C
Formula: C25H24O12
M.Wt: 516.453
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SL 0101-1 is a selective inhibitor of p90 Rsk (ribosomal S6 kinase) (IC50 = 89 nM for Rsk-2). This product does not inhibit upstream kinases such as MEK, Raf and PKC. SL 0101-1 inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line. For the detailed information of SL 0101-1, the solubility of SL 0101-1 in water, the solubility of SL 0101-1 in DMSO, the solubility of SL 0101-1 in PBS buffer, the animal experiment (test) of SL 0101-1, the cell expriment (test) of SL 0101-1, the in vivo, in vitro and clinical trial test of SL 0101-1, the EC50, IC50,and affinity,of SL 0101-1, For the detailed information of SL 0101-1, the solubility of SL 0101-1 in water, the solubility of SL 0101-1 in DMSO, the solubility of SL 0101-1 in PBS buffer, the animal experiment (test) of SL 0101-1, the cell expriment (test) of SL 0101-1, the in vivo, in vitro and clinical trial test of SL 0101-1, the EC50, IC50,and affinity,of SL 0101-1, Please contact DC Chemicals.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC8239 SL 0101-1 SL 0101-1 is a selective inhibitor of p90 Rsk (ribosomal S6 kinase) (IC50 = 89 nM for Rsk-2).
DC7696 FMK Fmk is an irreversible ribosomal S6 kinase inhibitor 1/2 inhibitor.
DC70703 PMD-026 PMD-026 (PMD026) is an oral, reversible small molecule inhibitor of ribosomal S6 kinase (RSK1-4) with IC50 of 2 nM (RSK1), 0.7 nM (RSK2), 0.9 nM (RSK3) and 2 nM (RSK4).PMD-026 decreased YB-1 phosphorylation as well as AR V7 mRNA and AR variants expressions in 22Rv1 cells.PMD-026 suppressed cell proliferation alone and in combination with the second-generation antiandrogens enzalutamide and darolutamide by inducing cellular apoptosis and G2/M arrest.PMD-026 suppressed tumor growth, and the combination of PMD-026 and enzalutamide inhibited tumor growth more prominently than single treatment in mouse xenograft models.
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