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Spantide I

  Cat. No.:  DC41643  
Chemical Structure
91224-37-2
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Field of application
Spantide I, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 91224-37-2
Chemical Name: Spantide I
Synonyms: {D-Arg}PKPQQ-{D-Trp}-F-{D-Trp}-LL-NH2
Formula: C75H108N20O13
M.Wt: 1497.79
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC47011 Elinzanetant Elinzanetant is a neurokinin receptors antagonist used for the research of Schizophrenia.
DC46851 Imnopitant Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) .
DC42312 Hemokinin 1 (mouse) Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.
DC42311 Neurokinin A TFA Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.
DC42048 Biotin-Substance P Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
DC41718 [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM.
DC41717 [Lys5,MeLeu9,Nle10]-NKA(4-10) [Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM.
DC41716 GR 64349 TFA GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively.
DC41715 GR 94800 TFA GR 94800 TFA is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively.
DC41714 GR 94800 GR 94800 is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively.
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