XRK3F2 |CAS 2375193-43-2|DC Chemicals

Cas No.:	2375193-43-2
Chemical Name:	XRK3F2
Synonyms:	XRK3F2;2-((3,4-Bis((4-fluorobenzyl)oxy)benzyl)amino)ethanol hydrochloride;2-[[3,4-bis[(4-fluorophenyl)methoxy]phenyl]methylamino]ethanol;hydrochloride;s8756;D80186
SMILES:	Cl[H].FC1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])OC1=C(C([H])=C([H])C(=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])O[H])OC([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])F
Formula:	C₂₃H₂₄ClF₂NO₃
M.Wt:	435.8914
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In Vitro The presence of XRK3F2 during MM-preOB co-cultures prevents Runx2 suppression at both d0 and d4. Furthermore, XRK3F2 blocks MM-induced upregulation of Gfi1. XRK3F2 blocks the induction of Gfi1 mRNA in BMSC in both treatment conditions. In contrast, XRK3F2 prevents both MM1.S CM and TNFα plus IL7-mediated Runx2 suppression. Further, the pro-inflammatory and myeloma pro-survival factor IL6 mRNA is also reduced by XRK3F2 treatment. In addition, XRK3F2 also prevents TNFα-mediated upregulation of Gfi1 and rescues inhibition of Runx2 in MC4 preOB. XRK3F2 prevents MM-induced GFI1 occupancy at the Runx2-P1 promoter. XRK3F2 treatment significantly rescues the H3K9ac levels at Runx2 in MM patient hBMSC and XRK3F2 can rescue early steps in osteogenesis.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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