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ALV2

  Cat. No.:  DC47521   Featured
Chemical Structure
2438124-95-7
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More than 5000 active chemicals with high quality for research!
Field of application
ALV2 is a potent and selective degrader of Helios, a zinc-finger transcription factor crucial for maintaining a stable regulatory T-cell (Treg) phenotype in inflammatory tumor microenvironments. ALV2 binds to CRBN with an IC50 of 0.57 μM, demonstrating its specificity and efficacy.
Cas No.: 2438124-95-7
Chemical Name: ALV2
Synonyms: Urea, N-​(3-​chloro-​4-​methylphenyl)​-​N'-​[1-​[3-​[[1-​(2,​6-​dioxo-​3-​piperidinyl)​-​2,​5-​dihydro-​2,​5-​dioxo-​1H-​pyrrol-​3-​yl]​amino]​phenyl]​-​1-​methylethyl]​-;ALV2
SMILES: C1=C(C=CC(C)=C1Cl)NC(=O)NC(C)(C)C1C=C(NC2C(=O)N(C3C(=O)NC(=O)CC3)C(C=2)=O)C=CC=1
Formula: C26H26ClN5O5
M.Wt: 523.97
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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