AS-1763|CAS 2227211-00-7|DC Chemicals

Cas No.:	2227211-00-7
Chemical Name:	US10793575, Example 23
Synonyms:	BDBM465748;US10793575, Example 23;2-(3-{2-amino-6-[1-(oxetan-3-yl)-1,2,3,6-tetrahydropyridin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-2-(hydroxymethyl)phenyl)-6-cyclopropyl-8-fluoroisoquinolin-1(2H)-one
SMILES:	FC1=C2C(N(C3=C([H])C([H])=C([H])C(=C3C([H])([H])O[H])C3=C4C(=NC(N([H])[H])=N3)N([H])C(=C4[H])C3=C([H])C([H])([H])N(C([H])([H])C3([H])[H])C3([H])C([H])([H])OC3([H])[H])C([H])=C([H])C2=C([H])C(=C1[H])C1([H])C([H])([H])C1([H])[H])=O
Formula:	C₃₃H₃₁FN₆O₃
M.Wt:	578.6361
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC47718	AS-1763	AS-1763 is an orally available, potent, and selective BTK inhibitor and shows excellent potency against both wild/C481S mutant BTKs with IC50 of 0.85 nM/0.99 nM.
DC11471	BGB-3111(Zanubrutinib)	Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor.
DC10044	ONO4059 analog	The product is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with an IC50 in the sub-nM range.
DC5146	RN486	RN-486 is a Bruton's tyrosine kinase (Btk) inhibitor.
DC1106	PCI-32765 (Ibrutinib)	PCI-32765 (Ibrutinib) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM.
DC10757	PCI-29732	PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
DC10043	ONO4059 hydrochloride	ONO-4059 is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM.
DC7937	LFM-A13	FM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC₅₀’s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK).
DC10380	Evobrutinib	Evobrutinib is an inhibitor of Bruton's tyrosin kinase (Btk) inhibitor extracted from patent US20140162983 example 0174.
DC7380	CGI-1746	CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation.