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Home > Enzymes substrates

Furimazine

  Cat. No.:  DC42623   Featured
Chemical Structure
1374040-24-0
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Field of application
Furimazine, an imidazopyrazinone-based substrate, generates exceptionally bright luminescence when paired with NanoLuc (Nluc). This combination produces a 2.5 million-fold increase in light output compared to the Oluc-19 and Coelenterazine system in mammalian cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1374040-24-0
Chemical Name: 8-Benzyl-2-[(furan-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Synonyms: Furimazine
SMILES: O=C1C(CC2=CC=CO2)=NC3=C(CC4=CC=CC=C4)NC(C5=CC=CC=C5)=CN31
Formula: C24H19N3O2
M.Wt: 381.44
Purity: > 99.5%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Hall MP, et al. Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate. ACS Chem Biol. 2012 Nov 16;7(11):1848-57.
Description: Furimazine is an imidazopyrazinone substrate. NanoLuc (Nluc) paired with Furimazine produced 2.5 million-fold brighter luminescence in mammalian cells relative to Oluc-19 with Coelenterazine.
References: [1]. Hall MP, et al. Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate. ACS Chem Biol. 2012 Nov 16;7(11):1848-57.
MSDS
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Cat. No. Product name Field of application
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DC67293 D-Val-Gly-Arg-pNA D-Val-Gly-Arg-p-nitroaniline (D-VGR-pNA)​ is a synthetic chromogenic peptide substrate specifically designed for assessing the enzymatic activity of tissue plasminogen activator (tPA), including its isoforms tPA I and tPA II. Upon cleavage by tPA, the release of p-nitroaniline (pNA) generates a measurable colorimetric signal, enabling precise quantification of amidolytic activity. This substrate is widely utilized in biochemical assays to study tPA’s role in fibrinolysis and to evaluate its enzymatic kinetics in both research and diagnostic applications.
DC60339 Cephalofurimazine (CFz) Cephalofurimazine (CFz) is a NanoLuc substrate optimized for enhanced brain performance. When paired with Antares luciferase, it generates over 20 times more signal from the brain compared to the traditional combination of D-luciferin and firefly luciferase.
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DCC5420 Viviren ViviRen is a synthetic analog of coelenterazine specifically designed for bioluminescence imaging (BLI), offering enhanced performance in visualizing biological processes.
DCC1510 Coelenterazine E Coelenterazine E serves as a bioluminescent probe, widely utilized for its ability to emit light in biological and chemical applications.
DC72431 For-Met-Leu-pNA（N-formylated peptide substrate) For-Met-Leu-pNA is an N-formylated peptide substrate specifically designed for use in deformylase activity assays, providing a reliable tool for studying enzyme function.
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