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HAIYPRH hydrochloride

  Cat. No.:  DC46524   Featured
Chemical Structure
268215-17-4
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More than 5000 active chemicals with high quality for research!
Field of application
HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 268215-17-4
Chemical Name: L-Histidine, L-histidyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-prolyl-L-arginyl-
Synonyms: L-Histidine, L-histidyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-prolyl-L-arginyl-
SMILES: N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(O)=O)CC1N=CNC=1)=O)CCCNC(=N)N)=O)=O)CC1=CC=C(O)C=C1)=O)[C@H](CC)C)=O)C)=O)CC1N=CNC=1
Formula: C41H60N14O9
M.Wt: 893.004
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
Description: HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier.
In Vivo: HAIYPRH hydrochloride, a transferrin receptor-specific peptide, is chosen as the ligand to target the co-delivery system to the tumor cells expressing transferrin receptors. HAIYPRH-modified co-delivery system shows higher efficiency in cellular uptake and gene expression than unmodified co-delivery system in U87 MG cells, and accumulated in tumor more efficiently in vivo[1].
In Vitro: HAIYPRH hydrochloride (T7) is conjugated to liposomes for ischemic stroke targeting treatment of a novel neuroprotectant (HY-100456: ZL006)[2]. HAIYPRH hydrochloride is a heptapeptide that can be used to target gliomas[3].
References: [1]. Liu S, et al. Gene and doxorubicin co-delivery system for targeting therapy of glioma. Biomaterials. 2012;33(19):4907‐4916. [2]. Wang Z, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015;5:12651. Published 2015 Jul 29. [3]. Ziyang Zhu, et al. Goat milk-derived exosomes Endowed with Radioactive and Targeting Properties: potential to provide PET/CT monitoring for exosomes-based drug delivery system in gliomas therapy. J Nucl Med May 1, 2020 vol. 61.
MSDS
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COA
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Cat. No. Product name Field of application
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DC74557 PREX-in1 PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain.
DC74555 GYS32661 GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
DC74539 L557-0155 L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth.
DC74528 K284 K284 is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.
DC74225 YB-537 YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).
DC74218 UT-59 UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.
DC74205 Tryptolinamide Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive
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