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Tofersen

Cat. No.: DC47285 Featured

Chemical Structure

2088232-70-4

For research use only. We do not sell to patients.

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Field of application

Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS).

Chemicals Properties Biological activity COA & MSDS Related products Datasheet

Cas No.:	2088232-70-4
Chemical Name:	Tofersen
Synonyms:	BIIB067; ISIS-SOD1Rx
M.Wt:	7128.00
Purity:	>95%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Target:	SOD 1
In Vitro:	Tofersen targets the SOD1 mRNA using antisense oligonucleotides (ASOs) that bind to the SOD1 mRNA by Watson-Crick base pairing. Tofersen activates RNase H1 that destroys the targeted RNA.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47285	Tofersen	Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS).

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.