| DC20594 |
(R)-ZINC-3573
Featured
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(R)-ZINC-3573 is a potent, selective agonist of the atypical opioid receptor MRGPRX2 (EC50=0.76 uM), showing little activity against 315 other GPCRs and 97 representative kinases. |
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| DC20247 |
(R,R)-BNC375
Featured
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(R,R)-BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs. |
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| DC23000 |
(-)-Perillyl alcohol
Featured
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(S)-(-)-Perillyl alcohol is a monoterpenoid compound found in the essential oils of cherries, lavender and spearmint. |
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| DC8451 |
(S)-Equol
Featured
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(S)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM). |
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| DC9137 |
Timolol Maleate
Featured
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(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively). |
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| DC26120 |
(Z)-4-hydroxy Tamoxifen
Featured
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(Z)-4-hydroxy Tamoxifen is a major phase I metabolite of tamoxifen, a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium. |
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| DC20576 |
Upacicalcet
Featured
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Upacicalcet is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT). |
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| DC20577 |
Valemetostat
Featured
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.Valemetostat is an antineoplastic agent. |
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| DC21937 |
Pecavaptan
Featured
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Pecavaptan is a vasopressin receptor antagonist. |
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| DC7800 |
RGW 611
Featured
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. For the detailed information of RGW 611, the solubility of RGW 611 in water, the solubility of RGW 611 in DMSO, the solubility of RGW 611 in PBS buffer, the animal experiment (test) of RGW 611, the cell expriment (test) of RGW 611, the in vivo, in vitro and clinical trial test of RGW 611, the EC50, IC50,and affinity,of RGW 611, Please contact DC Chemicals.. |
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| DCZ-059 |
L-Stepholidine
Featured
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Stepholidine s a naturally occurring chemical compound found in the herb Stephania intermedia. Stepholidine is a dual D2 receptor antagonist and D1 receptor agonist, and has shown antipsychotic activity in animal studies. |
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| DCL-027 |
Lipoic acid
Featured
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Lipoic acid is a selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM.
Lipoic acid shows a favorable selectivity profile on Nav, Cav, SK, and IK channels.
Lipoic acid causes distinct activation from a concentration of 0.3 and 10 µM Lipoic acid left-shifted the voltage activation curve by 60 mV.
Lipoic acid reduces spontaneous phasic contractions in guinea pig urinary bladder strips at 1 uM, while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions. |
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| DC22287 |
Atractylenolide I
Featured
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Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent. |
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| DC23034 |
Isochlorogenic acid C
Featured
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4,5-Dicaffeoylquinic acid ( Isochlorogenic acid C) possesses potent hepatoprotective and anti-HBV effects.IC50 value:Target: Anti-hepatitis natural produce.In vitro: To study anti-hepatitis effect of isochlorogenic acid C, anti-apoptotic and anti-injury properties of test compound were evaluated. The results showed that test compound at concentrations of 10 to 100 μg/ml significantly reduced the caspase-3 and transformed growth factor β1 (TGFβ1) levels of the D-GalN-challenged hepatocytes. Also, test compound improved markedly cell viability of the D-GalN-injured hepatocytes and produced a maximum protection rate of 47.28% at a concentration of 100 μg/ml. Furthermore, test compound significantly inhibited productions of HBsAg and HBeAg. Its maximum inhibitory rates on the HBsAg and HBeAg expressions were 86.93 and 59.79%, respectively. In addition, test compound significantly induced the HO-1 expression of HepG2.2.15 cells [1]. In vivo: |
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| DCZ-244 |
5-Hydroxy-1,4-naphthalenedione(Juglone)
Featured
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>98%,Standard References |
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| DCN-005 |
Butylparaben
Featured
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Butylparaben is an organic compound that has proven to be a very successful antimicrobial preservative in cosmetics, can also be used in active molecule suspensions, and as a food flavoring additive. |
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| DCT-015 |
Melatonine
Featured
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>98%,Standard References |
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| DC52032 |
Luteolin
Featured
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Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells. |
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| DC52031 |
Naringenin
Featured
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Naringenin is the predominant flavanone in grapefruit; displays strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity. |
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| DCX-037 |
linderalactone
Featured
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Linderalactone showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, values of IC5 is 8.48 μg/mL. |
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| DCG-020 |
Gliclazide
Featured
|
>98%,Standard References |
|
| DCQ-020 |
Oroxylin A
Featured
|
>98%,Standard References |
|
| DCZ-139 |
Higenamine hydrochloride
Featured
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Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases. |
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| DC55150 |
Gentiopicroside
Featured
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Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 µM and 22.8 µM for CYP2A6; Gentiopicroside has antianti-inflammatoryand antioxidative effects. |
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| DCJ-038 |
6-Shogaol
Featured
|
>98%,Standard References |
|
| DCR-045 |
Monomyristin
Featured
|
>98%,Standard References |
|
| DCH-004 |
Magnolol
Featured
|
>98%,Standard References |
|
| DC52030 |
Bakuchiol
Featured
|
Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea corylifolia L; has anti-tumor effects. |
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| DCY-109 |
Linolenic acid
Featured
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α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1]. |
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| DCY-156 |
cis-9-Octadecenoic acid
Featured
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cis-9-Octadecenoic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator. |
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