Cat. No. | Product name | CAS No. |
DC20564 |
TBBz
Featured
A potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM. |
577779-57-8 |
DC20309 |
ANTISAUVAGINE-30
Featured
A potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist with Ki of 1.4 nM, 100-fold selectiivity over CRF1. |
220673-95-0 |
DC11755 |
L-732138
Featured
A potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM. |
148451-96-1 |
DC21827 |
XE 991 dihydrochloride
Featured
A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively. |
122955-13-9 |
DC23371 |
NI-42
Featured
NI-42 is a potent, selective and orally active BRPF1 bromodomain inhibitor with IC50 of 7.9 nM, with excellent selectivity over nonclass IV BRDs; weakly inhibits BRPF2 (BRD1), BRPF3, BRD9 and BRD4 (BD1) with IC50 of 48, 260, 310 and 4500 nM respectively, and no activity for ATAD2A/2B (IC50>100 uM); shows a modest (GI50=1-10 uM) and selective inhibition of proliferation of certain cancer lines, particularly those lines exhibiting monocytic lineage differentiation; a novel, structurally orthogonal chemical probe for the BRPFs suitable for cellular and in vivo studies. |
1884640-99-6 |
DC21689 |
SR 142948A
Featured
A potent, selective and orally active neurotensin receptor antagonist with IC50 of 1.19 nM. |
184162-21-8 |
DC23207 |
JNJ-17203212
Featured
A potent, selective and orally bioavailable TRPV1 receptor antagonist with IC50 of 65 nM and 102 nM for hTRPV1 and rTRPV1, respectively. |
821768-06-3 |
DC11511 |
A-485
Featured
A potent, selective and, cell and in vivo active p300/CBP catalytic inhibitor with IC50 of 9.8/2.6 nM. |
1889279-16-6 |
DC20602 |
5F 203
Featured
A potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway. |
260443-89-8 |
DC20658 |
AM1241
Featured
A potent, selective cannabinoid receptor CB2 agonist with Ki of 7.1 nM, >80-fold selectivity over CB1 receptors in radioligand binding assay. |
444912-48-5 |
DC22917 |
SCH 79797 dihydrochloride
Featured
A potent, selective competitive and nonpeptide PAR-1 antagonist with IC50 of 70 nM. |
1216720-69-2 |
DC11866 |
AZD 3147
Featured
A potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM. |
1101810-02-9 |
DC11617 |
PU-H54
Featured
PU-H54 is potent, selective Grp94 inhibitor. |
1454619-13-6 |
DC22946 |
ML-T531
Featured
ML-T531 is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM. |
791127-70-3 |
DC22966 |
ABH hydrochloride
Featured
A potent, selective human Arginase inhibitor with Ki of 0.25 uM (pH=7.5), 8.5 nM (pH=9.5) for type II arginase. |
194656-75-2 |
DC11857 |
BAY-8040 (R)
Featured
Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension. |
1194453-23-0 |
DC11706 |
R-10015
Featured
A potent, selective inhibitor of human LIMK1 with IC50 of 38 nM . |
2097938-51-5 |
DC23189 |
CL-82198
Featured
CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression. |
307002-71-7 |
DC22625 |
Rolipram
Featured
A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. |
61413-54-5 |
DC11507 |
CLP257
Featured
CLP257 (CLP-257) is a potent, selective K+-Cl- cotransporter KCC2 activator with EC50 of 616 nM; displays selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, and a panel of 55 other receptors; restores impaired Cl(-) transport i |
1181081-71-9 |
DC11503 |
KDOAM-25
Featured
A potent, selective KDM5 sub-family(JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively. |
2230731-99-2 |
DC11650 |
Ro5-4864
Featured
A potent, selective ligand for the mitochondrial translocator protein 18kDa (TSPO/PBR). |
14439-61-3 |