Cat. No. | Product name | CAS No. |
DC11451 |
STING agonist compound 1
Featured
diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
2138299-33-7 |
DC10960 |
STING inhibitor C-176
Featured
STING inhibitor C-178 is a covalent, in vivo-active, small-molecule inhibitor of STING |
314054-00-7 |
DC10959 |
STING inhibitor C-178
Featured
STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING). |
329198-87-0 |
DC10201 |
STK16-IN-1
Featured
STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM. |
1223001-53-3 |
DC9844 |
STK321130(FLT3-IN-2)
Featured
STK321130(FLT3-IN-2)is potent FLT3 inhibitor |
923562-23-6 |
DC11264 |
STO-609 (acetate)
Featured
STO-609 is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ (Ki = 80 and 15 ng/ml, respectively). |
1173022-21-3 |
DC9961 |
STO-609
Featured
STO-609 is a selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively); competes for the ATP-binding site. |
52029-86-4 |
DCAPI1552 |
streptomycin
Featured
Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes . |
57-92-1 |
DC21709 |
SU 16f
Featured
SU 16f is a potent and selective PDGFRβ inhibitor with IC50 of 10 nM, displays >14-fold, >229-fold and >10,000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. |
251356-45-3 |
DC10602 |
SU 4313
Featured
SU 4313 is a bioactive chemical. |
186611-55-2 |
DC10601 |
SU 4942
Featured
SU 4942 is a bioactive chemical. |
76086-99-2 |
DC10600 |
SU 5205
Featured
SU 5205 is a VEGFR2 inhibitor. |
3476-86-6 |
DC10519 |
SU 5214
Featured
SU 5214 is a modulator of tyrosine kinase signal transduction. |
186611-04-1 |
DC8102 |
SU6656
Featured
SU 6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). |
330161-87-0 |
DC1093 |
SU11274 (PKI-SU11274)
Featured
SU11274 is a selective Met inhibitor with IC50 of 10 nM. |
658084-23-2 |
DC7302 |
SU14813
Featured
SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). |
627908-92-3 |
DC7509 |
SU1498
Featured
SU1498 is a selective inhibitor of the VEGFR2; inhibits Flk-1with an IC50 of value of 700 nM. |
168835-82-3 |
DC9781 |
SU4312(NSC86429)
Featured
SU4312(NSC86429) is a selective, cell-permeable inhibitor of VEGFR2 and PDGFR tyrosine kinases (IC50s = 0.8 and 19.4 μM, respectively). |
5812-07-7 |
DC7508 |
SU 5402
Featured
SU5402(SU-5402; SU5402) is potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor. (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). |
215543-92-3 |
DC9950 |
SU5614
Featured
SU5614 is a potent and selective FLT3 inhibitor. |
1055412-47-9 |
DC5079 |
Orantinib (TSU-68)
Featured
SU6668 has greatest potency against PDGFR autophosphorylation with Ki of 8 nM, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. |
252916-29-3 |
DC21710 |
SU-909
Featured
SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM); inhibits FCS-stimulated phosphorylation of p100 in U2OS cells with IC50 of 8.8 uM, inhibits the noncanonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway. |
2126749-48-0 |
DC7928 |
SU9516
Featured
SU-9516 is a selective CDK2 inhibtor with IC50 of 22 nM; less potent for CDK1/CDK4(IC50=40/200 nM), no inhibition on PKC, EGFR, p38MAPK etc. |
377090-84-1 |
DC6906 |
Aprepitant (MK-0869, L-754030)
Featured
Substance P antagonists (SPA). |
170729-80-3 |
DC10664 |
Substance P free acid
Featured
Substance P free acid is a Sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission. |
71977-09-8 |
DC10663 |
Substance P
Featured
Substance P is a Sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission. |
33507-63-0 |
DC11334 |
Suc-Ala-Ala-Pro-Abu-pNA trifluoroacetate salt
Featured
Suc-AAP-Abu-pNA is a chromogenic peptide substrate for pancreatic elastase.It is cleaved by elastase to release p-nitroalinide (p-NA), which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity. |
108392-27-4 |
DC10581 |
Succinobucol(AGI 1067)
Featured
Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects. |
216167-82-7 |
DC26055 |
Caspase-1/4 Chromogenic Substrate(Suc-YVAD-pNA)
Featured
Suc-YVAD-pNA is a colorimetric substrate for caspase-1/interleukin-1β-converting enzyme (ICE) and caspase-4. |
208264-84-0 |
DC9732 |
Sufugolix(TAK-013)
Featured
Sufugolix(TAK-013) is a non-peptide, orally-active, selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (IC50 = 0.1 and 0.06 nM for affinity and in vitro inhibition, respectively). |
308831-61-0 |
DC22567 |
Sulfatinib
Featured
Sulfatinib (HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively. |
1308672-74-3 |
DC10349 |
Sumanirole maleate
Featured
Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. |
179386-44-8 |
DC10271 |
SUN11602
Featured
SUN11602 is a novel aniline compound, which mimics the neuroprotective mechanisms of basic fibroblast growth factor. |
704869-38-5 |
DC3145 |
Sunitinib base
Featured
Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. |
557795-19-4 |
DC3146 |
Sunitinib malate
Featured
Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. |
341031-54-7 |
DC20205 |
Super-TDU
Featured
Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction. |
1599441-71-0 |
DC10733 |
Sutezolid (PNU-100480)
Featured
Sutezolid (PNU-100480) is an oxazolidinone antimicrobial being developed for the treatment of tuberculosis. |
168828-58-8 |
DC22238 |
SUVN-G3031
Featured
SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R). |
1394808-82-2 |
DC5017 |
Suvorexant
Featured
Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.Suvorexant is an analytical reference standard categorized as a diazepane sedative.Formulations containing suvorexant show abuse potential similar to zolpidem in recreational polydrug users with a history of sedative and psychedelic drug use.2 Suvorexant is regulated as a Schedule IV compound in the United States. This product is intended for use in analytical forensic applications. |
1030377-33-3 |
DC8267 |
SW033291
Featured
SW033291 is a potent inhibitor of 15-PGDH enzyme with IC50 value of 1.5 nM and dissociation constant Ki app value of 0.1 nM. |
459147-39-8 |
DC8852 |
SW-044248
Featured
SW-044248 is a Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines. |
522650-83-5 |
DC10965 |
SW076956
Featured
SW076956 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity. |
851717-83-4 |
DC12634 |
SW-100
Featured
SW-100 (SW100) is a potent, selective, brain penetrable HDAC6 inhibitor with IC50 of 2.3 nM, displays >1,000-fold selectivity over all other class I, II, and IV HDAC isoforms. |
2126744-35-0 |
DC21715 |
Gliocidin
Featured
Gliocidin is a prodrug that is anabolized into its tumoricidal metabolite, gliocidin–adenine dinucleotide (GAD). Gliocidin kills glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2). Gliocidin penetrates the blood–brain barrier and extends the survival of mice with orthotopic glioblastoma. |
62289-81-0 |
DC24205 |
SY-1365
Featured
SY-1365 is a CDK7 inhibitor. In vitro, SY-1365 inhibited cell growth of many different cancer types at nanomolar concentrations. |
1816989-16-8 |
DC10900 |
Syk inhibitor II
Featured
Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. |
726695-51-8 |
DC10436 |
SYP-5
Featured
SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. |
1384268-04-5 |
DC5105 |
Favipiravir (T-705)
Featured
T 705(Favipiravir) is a RNA-directed RNA polymerase NS5B inhibitor.T 705(Favipiravir) is useful for Antiviral agents. |
259793-96-9 |
DC8063 |
T-00127-HEV1
Featured
T-00127-HEV1 is a novel potent phosphoinositide kinases (PIK) inhibitor,T-00127-HEV1 inhibited PI4KB activity with a higher specificity for than other PI kinases. |
900874-91-1 |
DC9601 |
T0070907
Featured
T0070907 is a potent and selective PPARγ antagonist with IC50 of 1 nM; displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. |
313516-66-4 |
DC9842 |
T0901317
Featured
T0901317 is a potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). |
293754-55-9 |
DC21956 |
T16Ainh-A01
Featured
T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl− channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM; T16Ainh-A01 (1-30 uM) inhibited single calcium (Ca2+)-activated chloride (Cl−) channels and whole cell currents activated by 500 nM free Ca2+; T16Ainh-A01 relaxed mouse thoracic aorta pre-contracted with methoxamine with an IC50 of 1.6 uM and suppressed the methoxamine concentration-effect curve; blocks calcium-activated chloride channels in vascular smooth muscle cells and relaxes murine and human blood vessels. |
552309-42-9 |
DC20124 |
T-26c
Featured
T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes. |
869296-13-9 |
DC11703 |
T-3775440 hydrochloride
Featured
T-3775440 hydrochloride is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM. |
1422535-52-1 |
DC12606 |
T-448
Featured
T-448 (T448) is a specific inhibitor of LSD1 enzyme activity, enhances H3K4 methylation in primary cultured rat neurons but has little impact on LSD1-GFI1B complex in human TF-1a erythroblasts. |
1597426-53-3 |
DC8024 |
T-5224
Featured
T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1, attenuates lipopolysaccharide-induced liver injury in mice. |
530141-72-1 |
DC10067 |
T-5601640(T56-LIMKi)
Featured
T56-LIMKi is a LIMK2 inhibitor that reduces phosphorylated cofilin, and induces disassembly of actin stress fibers in NF1-/- MEFs cells. |
924473-59-6 |
DC12534 |
T5910047
Featured
T5910047 (T-5910047) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation; inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM. |
950003-29-9 |
DC8058 |
T863
Featured
T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor |
701232-20-4 |
DC9301 |
TA-01
Featured
TA-01 induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction at 1 μM. Inhibits cardiomyocyte differentiation at 5 μM. Potently inhibits CK1ε, p38α, and CK1δ (IC50 values are 6.4, 6.7 and 6.8 nM respectively). |
1784751-18-3 |
DC9300 |
TA-02
Featured
TA-02 induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction. Potently inhibits p38α, CK1δ and CK1ε (IC50 values are 20, 32 and 32 nM respectively). |
1784751-19-4 |
DC22299 |
Tabersonine
Featured
Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus. |
29479-00-3 |
DC5901 |
Tadalafil
Featured
Tadalafil is a potent and selective inhibitor of Phosphodiesterase-5 (PDE5) This compound prevents the breakdown of phosphodiesterases, many of which are used as secondary messengers. By preventing the breakdown of these messenger molecules, tadalafil can |
171596-29-5 |
DC7885 |
NVP-TAE226
Featured
TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. |
761437-28-9 |
DC10756 |
PF-06291826(Tafamidis)
Featured
Tafamidis is a novel specific transthyretin (TTR) stabilizer or dissociation inhibitor. |
594839-88-0 |
DC12377 |
Tafamidis meglumine
Featured
Tafamidis is a novel specific transthyretin (TTR) stabilizer or dissociation inhibitor. |
951395-08-7 |
DC21609 |
Tafenoquine
Featured
Tafenoquine (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.. |
106635-80-7 |
DC21610 |
Tafenoquine succinate
Featured
Tafenoquine succinate (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.. |
106635-86-3 |
DC8148 |
TAI-1
Featured
TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction. |
1334921-03-7 |
DC7945 |
TAK-063
Featured
TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. |
1238697-26-1 |
DC11208 |
TAK-071
Featured
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM. |
1820812-16-5 |
DC9311 |
Serabelisib(TAK-117,INK1117,MLN1117)
Featured
TAK-117(INK1117,MLN1117) is an orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha isoform with potential antineoplastic activity. |
1268454-23-4 |
DC7305 |
TAK-242 (Resatorvid)
Featured
TAK-242 (Resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. |
243984-11-4 |
DC11633 |
TAK-243
Featured
TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1). |
1450833-55-2 |
DC7057 |
TAK-285
Featured
TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. |
871026-44-7 |
DC7306 |
TAK-438
Featured
TAK-438 is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. |
1260141-27-2 |
DC7923 |
TAK-599 (ceftaroline fosamil)
Featured
TAK-599 is a highly promising parenteral cephalosporin targeted for MRSA infection. |
400827-46-5 |
DC10923 |
TAK-615
Featured
TAK-615 (TAK615) is a potent, selective, negative allosteric modulator (NAM) of the LPA1 receptor, partially inhibits the LPA response with IC50 of 91 nM (60% at 10 uM) in calcium mobilisation assays.. |
1664335-55-0 |
DC7307 |
TAK-632
Featured
TAK-632 is a selective pan-RAF kinase inhibitor with IC50 values of 2.4/1.4 nM for BRAF V600E/c-RAF; > 60 fold selectivity over VEGFR. |
1228591-30-7 |
DC21280 |
TAK-659 free base(Mivavotinib)
Featured
TAK-659 (TAK659, Mivavotinib) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM. |
1312691-33-0 |
DC10523 |
TAK-659 HCl
Featured
TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM. |
1952251-28-3 |
DC7308 |
TAK-733
Featured
TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. |
1035555-63-5 |
DC11397 |
TAK-779
Featured
TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells. |
229005-80-5 |
DC5073 |
TAK-875(Fasiglifam)
Featured
TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 0.072 μM. |
1000413-72-8 |
DC21653 |
Simurosertib (TAK-931)
Featured
TAK-931 (Simurosertib) is a potent, selective, ATP competitive and orally bioavailable inhibitor of Cdc7 with IC50 of <0.3 nM. |
1330782-76-7 |
DC7309 |
TAK-960
Featured
TAK-960 is a novel, potent and selective Polo-like kinase 1 (PLK1) inhibitor. |
1137868-52-0 |
DC10065 |
Takeda-6d
Featured
Takeda-6d has potent inhibitory activity in both B-RAF with an IC50 of 7.0 nM and VEGFR2 with an IC50 of 2.2 nM. |
1125632-93-0 |
DC10661 |
Takinib
Featured
Takinib is a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. |
1111556-37-6 |
DC7863 |
Talampanel (GYKI 53773)
Featured
Talampanel is a novel anticonvulsant that acts as an allosteric inhibitor of the AMPA receptor. |
161832-65-1 |
DC7310 |
Tamibarotene(Am-80)
Featured
Tamibarotene(Am-80) is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. |
94497-51-5 |
DC9096 |
Tamoxifen
Featured
Tamoxifen(ICI-46474) is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. |
10540-29-1 |
DC9180 |
Tamoxifen Citrate
Featured
Tamoxifen(ICI-46474) is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen,showed potent activity against COVID-19(SARS-COV-2) with EC50 MERS-COV(10.117), SARS-COV(11.696). |
54965-24-1 |
DC23076 |
Tanshinone I
Featured
Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM). |
568-73-0 |
DC23815 |
TAO Kinase inhibitor 1
Featured
TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively; increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growth in centrosome-amplified SKBR3 or BT549 breast cancer cell models. |
850467-66-2 |
DC8131 |
TAPI-2 (TNF Protease Inhibitor 2)
Featured
TAPI-2 inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 µM, respectively. |
187034-31-7 |
DC10624 |
Targocil
Featured
Targocil is a novel antibiotics against Methicillin-resistant Staphylococcus aureus (MRSA). |
1200443-21-5 |
DC1102 |
Tariquidar (XR9576)
Featured
Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM. |
206873-63-4 |
DC22243 |
TAS0728
Featured
TAS0728 (TAS-0728, TAS 0728) is a potent, selective, covalent, orally available inhibitor of HER2 kinase with IC50 of 36 nM in in vitro kinase assays. |
2088323-16-2 |
DC10369 |
TAS-102
Featured
TAS-102 is a novel oral combination drug that consists of an antineoplastic thymidine-based nucleoside analog, trifluorothymidine, and a potent thymidine phosphorylase inhibitor, tipiracil, in a 1:0.5 molar ratio. |
733030-01-8 |
DC8536 |
TAS-103 2HCl
Featured
TAS-103 2Hcl(BMS-247615 2Hcl) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
174634-09-4 |
DC20274 |
Pamufetinib (TAS-115)
Featured
Pamufetinib (TAS-115) is a potent VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively. |
1190836-34-0 |
DC12256 |
TAS-115 mesylate (TAS-115 methanesulfonate)
Featured
TAS-115 mesylate is a potent VEGFR and c-Met/HGFR kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively. |
1688673-09-7 |
DC21736 |
TAS-117
Featured
TAS-117 is a highly selective, non-ATP competitive pan-Akt inhibitor with IC50 of 4.8/1.6/44 nM for Akt1/Akt2/Akt3 respectively. |
1402602-94-1 |
DC8376 |
TAS-301
Featured
TAS-301 is an inhibitor of smooth muscle cell migration and proliferation. |
193620-69-8 |
DC7312 |
Tasisulam(LY573636)
Featured
Tasisulam sodium is The sodium salt of an acyl-sulfonamide with potential antineoplastic activity. |
519055-62-0 |
DC22528 |
Taspoglutide
Featured
Taspoglutide is a glucagon-like peptide-1(GLP-1) agonist for treatment of type 2 diabetes. |
275371-94-3 |
DC7733 |
Tasquinimod(ABR-215050)
Featured
Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. |
254964-60-8 |
DC22522 |
Tat-NR2B9c
Featured
Tat-NR2B9c (NA-1) is a neuroprotective agent. |
500992-11-0 |
DC7619 |
Tazarotenic acid (AGN 190299)
Featured
Tazarotenic Acid is an agent that acts as the principle active metabolite |
118292-41-4 |
DC9996 |
TB5
Featured
TB5 is a potent, selective and reversible inhibitor of hMAO-B with a Ki value of 0.11±0.01 μM. |
948841-07-4 |
DC9400 |
TBB
Featured
TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). |
17374-26-4 |
DC7932 |
TBPB
Featured
TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats. |
634616-95-8 |
DC7555 |
TC-DAPK-6
Featured
TC-DAPK 6 is an oxazalone compound that acts as a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor (IC50 = 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 uM ATP). |
315694-89-4 |
DC11125 |
TCH-165
Featured
TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation. |
1446350-60-2 |
DC7513 |
TCS 1102
Featured
TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). |
916141-36-1 |
DC7313 |
TCS 359
Featured
TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. |
301305-73-7 |
DC23216 |
TCS 401
Featured
TCS 401 is a potent, selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) with Ki of 0.29 uM, weakly inhibits the protein phosphatases CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1, and LAR D1D2 with Ki of 59, 560, 1,100, >2,000, >2,000, and >2,000 u |
243966-09-8 |
DC8262 |
TCS 5861528
Featured
TCS 5861528 is a TRPA1 channel blocker and an antagonizer of AITC- and 4-HNE-evoked calcium influx. |
332117-28-9 |
DC7514 |
TCS PIM-1 1
Featured
TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM). |
491871-58-0 |
DC8093 |
TCS JNK 5a(JNK Inhibitor IX)
Featured
TCS-JNK-5a is a selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively). |
312917-14-9 |
DC11461 |
TCS-OX2-29
Featured
TCS-OX2-29 is a potent and selective OX2 receptor antagonist with IC50 of 40 nM. Displays >250-fold selectivity for OX2 over OX1. |
372523-75-6 |
DC12587 |
TD-0212
Featured
TD-0212 (TD0212) is a potent, orally efficacious, dual AT1 antagonist/Neprilysin (NEP) inhibitor with pKi of 8.9 (AT1) and pIC50 of 9.2 (NEP). |
1073549-10-6 |
DC10390 |
TD139
Featured
TD139 is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain with a Kd of 14 nM. |
1450824-22-2 |
DC10118 |
TD-198946
Featured
TD-198946(TD198946 ) is a small molecule stimulator of chondrogenesis; promotes chondrocyte differentiation. |
364762-86-7 |
DC8813 |
TD-4208
Featured
TD-4208 is a potent and selective inhaled muscarinic antagonist with functional lung selectivity and long duration of action in preclinical models of bronchoconstriction. |
864750-70-9 |
DC2067 |
TDZD-8
Featured
TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM. |
327036-89-5 |
DC11026 |
Tecovirimat
Featured
Tecovirimat (ST-246, Tpoxx) is a potent, orally bioavailable, first-in-class inhibitor of orthopoxvirus egress with EC50 of 0.01-0.6 uM against a panel of Orthopoxviruses; ST-246 is active against multiple orthopoxviruses, including vaccinia, monkeypox, c |
869572-92-9 |
DC12603 |
TED-347
Featured
TED-347 (TED347) is an irreversible inhibitor of TEAD4-Yap1 protein-protein interaction (EC50=5.9 uM in FP asssays) via covalent modification of conserved cysteine (Cys367, Ki=1.3 uM), inhibits its binding to Yap1, blocked its transcriptional activity. |
2378626-29-8 |
DC8962 |
Tegafur
Featured
Tegafur (also known as Ftorafur) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil. |
17902-23-7 |
DC9315 |
Tegaserod (maleate)
Featured
Tegaserod maleate is a partial agonist of the 5-HT4 receptor; stimulates the peristaltic reflex and accelerates gastrointestinal transit. |
189188-57-6 |
DC20756 |
Tegatrabetan
Featured
Tegatrabetan (BC-2059, BC2059, Tegavivint) is an orally bioavailable β-catenin antagonist that disrupts the binding of β-catenin to TBL1 and promotes β-catenin degradation, attenuates nuclear and cytoplasmic levels of β-catenin. |
1227637-23-1 |
DC7515 |
Teglicar
Featured
Teglicar, in vitro and in animal models, reduces gluconeogenesis and improves glucose homeostasis, refreshing the interest in selective and reversible L-CPT1 inhibition as a potential antihyperglycemic approach. |
250694-07-6 |
DC9463 |
Tegobuvir (GS-9190; GS 333126)
Featured
Tegobuvir (GS-9190; GS 333126) is a non-nucleoside nonstructural protein (NS)5B polymerase inhibitor. |
1000787-75-6 |
DC20155 |
Tegoprazan
Featured
Tegoprazan, a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro. |
942195-55-3 |
DCAPI1555 |
Teicoplanin
Featured
Teicoplanin Complex is a complex of antibiotics produced by Actinoplanes teichomyceticus. Teicoplanin, the major component of Teicoplanin Complex, is a glycopeptide antibiotic structurally similar to Vancomycin (sc-204938) and Ristocetin (sc-202318). As a |
61036-62-2 |
DC1008 |
Telaprevir (VX-950)
Featured
Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM. |
402957-28-2 |
DC9586 |
Telatinib
Featured
Telatinib(Bay 57-9352) is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively. |
332012-40-5 |
DCAPI1102 |
Telithromycin (Ketek)
Featured
Telithromycin (Ketek) |
191114-48-4 |
DC21273 |
Telratolimod
Featured
Telratolimod (MEDI 9197, 3M 052) is a novel, injectable, tissue-retained TLR7/8 agonist that forms a tissue depot with gradual, sustained release, allowing local TLR triggering activity without systemic cytokine release. |
1359993-59-1 |
DCAPI1488 |
Temsirolimus
Featured
Temsirolimus is an inhibitor of ribosomal protein S6 phosphorylation and inhibits cell growth and clonogenic survival of cells in a concentration-dependent manner. |
162635-04-3 |
DC10386 |
Tenapanor
Featured
Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively. |
1234423-95-0 |
DC8370 |
Teneligliptin hydrobromide
Featured
Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM. |
906093-29-6 |
DC4156 |
Tenofovir disoproxil fumarate
Featured
Tenofovir disoproxil fumarate belongs to nucleotide analogue reverse transcriptase inhibitors (nRTIs). |
202138-50-9 |
DC9780 |
Tenofovir disoproxil
Featured
Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV. |
201341-05-1 |
DC1065 |
Tenovin-1
Featured
Tenovin-1 is a p53 activator and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. |
380315-80-0 |
DC7314 |
Tenovin-3
Featured
Tenovin-3 is a small molecule activator of p53 transcriptional activity. |
1011301-27-1 |
DC7315 |
Tenovin-6
Featured
Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator. |
1011557-82-6 |
DCAPI1344 |
Terbinafine HCl
Featured
Terbinafine also known under the trade name Lamisil. It is highly hydrophobic and tends to accumulate in hair, skin, nails, and fatty tissue. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. |
78628-80-5 |
DC8697 |
Terbuthylazine
Featured
Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide. |
5915-41-3 |
DC4221 |
Teriflunomide(A-771726)
Featured
Teriflunomide: Teriflunomide, aslo know as A77 1726 (trade name Aubagio, marketed by Sanofi) is the active metabolite of leflunomide. |
163451-81-8 |
DC9609 |
Terutroban
Featured
Terutroban is a thromboxane/prostaglandin endoperoxide receptor antagonist. |
165538-40-9 |
DC22245 |
TES-1025
Featured
TES-1025 (TES1025) is a potent, selective inhibitor of human ACMSD (α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase) with IC50 of 13 nM, increases NAD+ levels in cellular systems. |
1883602-21-8 |
DC11013 |
Tesirine
Featured
Tesirine ( SG3249) is a cathepsin B-cleavable valine-alanine pyrrolobenzodiazepine (PBD) dimer as antibody-drug conjugate (ADC) payload. |
1595275-62-9 |
DC9866 |
Tetrabenazine
Featured
Tetrabenazine has been used for dopamine uptake assays in mouse brain cells1. |
58-46-8 |
DC12218 |
Tetradecanoylcarnitine
Featured
Tetradecanoylcarnitine is a human carnitine involved in β-oxidation of long-chain fatty acids. |
25597-07-3 |
DC8932 |
TG003
Featured
TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC. |
300801-52-9 |
DC7516 |
TG100-115
Featured
TG100115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2. |
677297-51-7 |
DC7317 |
TG101209
Featured
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations; TG101209 inhibit BRD4 activity with IC50 of 130 nM. |
936091-14-4 |
DC7318 |
TG101348(Fedratinib)
Featured
TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3, TG-101348 also inhibit BRD4 with IC50 of 340 nM. |
936091-26-8 |
DC22308 |
TG4-155
Featured
TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels. It blocks the induced expression of inflammatory markers in microglial cells. |
1164462-05-8 |
DC8511 |
TG-46
Featured
TG-46 is an inhibitor of JAK2, FLT3, RET, JAK3 with IC50 values of 6nM, 25nM, 17nM, 169nM respectively. |
936091-15-5 |
DC8348 |
TG6-10-1
Featured
TG6-10-1 is a cell-permeable,highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb = 17.8 nM). |
1415716-58-3 |
DC21748 |
TG693
Featured
TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM. |
885272-55-9 |
DC12506 |
TG8-69
Featured
TG8-69 is a peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with Kb of 48.5 nM. |
|
DC8510 |
TG-89
Featured
TG-89 is a JAK inhibitor. It has IC50 values of 6, 25, 17 and 169 nM against JAK2, FLT3, RET and JAK3 respectively. |
936091-56-4 |
DC7559 |
TGF-B (beta) receptor inhibitor
Featured
TGF-β receptor inhibitor |
476474-11-0 |
DC12042 |
TGN-020
Featured
TGN 020 is a thiadiazole derivative studied for its potential antitumor properties |
51987-99-6 |
DC8653 |
TGR-1202(Umbralisib)
Featured
TGR-1202 is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively. |
1532533-67-7 |
DC7321 |
TGX221
Featured
TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β . |
663619-89-4 |
DC7725 |
TH 287
Featured
TH 287 is a first-in-class MTH1 inhibitor (IC50 value 5.0 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells. |
1609960-30-6 |
DC7645 |
TH-237A
Featured
TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier. |
935467-97-3 |
DC12564 |
TH-257
Featured
TH-257 (TH257) is a potent, selective, allosteric inhibitor of LIMK1 and LIMK2 with IC50 of 84 nM for LIMK1 and 39 nM for LIMK2 in a RapidFire MS assay. |
2244678-29-1 |
DC7689 |
Evofosfamide(TH-302)
Featured
TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism. |
918633-87-1 |
DC12487 |
TH-34
Featured
TH34 is a potent HDAC6/8/10 inhibitor, induceing DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. |
2196203-96-8 |
DC23145 |
TH5487
Featured
TH5487 (TH-5487, TH 5487) is a potent, selective, active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM, prevents OGG1 from binding to its DNA substrate. |
2304947-71-3 |
DC7726 |
TH 588
Featured
TH588 is a novel potent, selective and cell permeable inhibitor of the nudix hydrolase family MTH1 protein with an IC50 of ~5 nM. |
1609960-31-7 |
DC9009 |
Thalidomide
Featured
Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo. |
50-35-1 |
DC26125 |
Cereblon Ligand-Linker Conjugates 3 (TFA)
Featured
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. |
1957236-21-3 |
DC11749 |
THAL-SNS-032
Featured
THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). |
2139287-33-3 |
DC8261 |
(-)-JQ-1
Featured
The (-)-JQ1 stereoisomer has no appreciable affinity to BET bromodomains,it is the negative control of +JQ-1. |
1268524-71-5 |
DC23990 |
N-Desethyl Sunitinib
Featured
The active metabolite of sunitinib, which is an oral, small-molecule, multi-targeted RTKs inhibitor for the treatment of RCC and imatinib-resistant GIST.. |
356068-97-8 |
DC9373 |
5-TAMRA
Featured
The amine-reactive 5-TAMRA, SE and its conjugates yield bright, pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability. |
91809-66-4 |
DC8509 |
Akt-I-1
Featured
The compound (Akt-I-1) inhibits only Akt1 (IC50 4.6 μM) and does not inhibit AKT2, or AKT3. |
473382-39-7 |
DC10055 |
Akt-I-1,2 HCl
Featured
The compound (Akt-I-1,2) inhibited both Akt1 and Akt2 with IC50 values of 2.7 and 21 μM respectively. |
473382-50-2 |
DC11263 |
COX-1 Inhibitor IV(TFAP)
Featured
The COX-1 Inhibitor IV, TFAP controls the biological activity of COX-1. |
1011244-68-0 |
DC23959 |
Aliskiren
Featured
The first in a class, potent and highly selective, direct renin inhibitor with IC50 of 0.6 nM. |
173334-57-1 |
DC11818 |
SCB-4380
Featured
SCB-4380 (SCB 4380, SCB4380) is the first potent, selective inhibitor for PTPRZ (protein tyrosine phosphatase receptor-type Z) with IC50 of 0.4 uM against human Z-ICR-catalyzed hydrolysis. SCB-4380 also strongly inhibits PTPRG (IC50=0.4 uM), and shows little inhibition on PTPRA, PTPRM, PTPRS, PTPRB, PTPN1 and PTPN6. SCB-4380 inhibites PTPRZ activity in C6 glioblastoma cells, and suppresse cell migration and proliferation in vitro and tumor growth in a rat allograft model. |
915-67-3 |
DC11947 |
ML418
Featured
The first potent, selective, CNS penetrating inward rectifier potassium channel Kir7.1 (KCNJ13) inhibitor with IC50 of 0.31 uM. |
1928763-08-9 |
DC26077 |
EG00229
Featured
The first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1). |
1210945-69-9 |
DC7680 |
IM-12
Featured
The GSK3β Inhibitor XIX, IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling. |
1129669-05-1 |
DC8854 |
ARS-853 intermediate
Featured
The intermediate of ARS-853.ARS-853 is a selective, covalent inhibitor of KRAS-G12C that inhibits mutant KRAS driven signaling by binding to the GDP bound oncoprotein and preventing activation. |
|
DC24187 |
Calcifediol monohydrate
Featured
The major circulating metabolite of vitamin D3. |
63283-36-3 |
DC7401 |
Des(benzylpyridyl) Atazanavir
Featured
The N-dealkylated metabolite (M1) of Atazanavir (A790051), a HIV protease inhibitor. |
1192224-24-0 |
DC23923 |
D-Glutamic acid
Featured
The one form of glutamic acid found in nature, is the most potent natural inhibitor of glutathione synthesis. |
6893-26-1 |
DC23916 |
Human growth hormone-releasing factor
Featured
Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary. |
83930-13-6 |
DC24002 |
Adrafinil
Featured
The prodrug of modafinil that is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention.. |
63547-13-7 |
DC10044 |
ONO4059 analog
Featured
The product is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with an IC50 in the sub-nM range. |
1351635-67-0 |
DC23174 |
GNE-140 racemate
Featured
The racemate of GNE-140, a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively. |
1802977-61-2 |
DC10469 |
ST-271
Featured
The tyrosine kinase inhibitor ST271 inhibited phospholipase D (PLD) activity in human neutrophils stimulated by fMet-Leu-Phe, platelet-activating factor and leukotriene B4. |
106392-48-7 |
DC11272 |
AG-126
Featured
The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. |
118409-62-4 |