| DC8397 |
AMG 925
Featured
|
AMG 925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively; with IC50 of 19 nM in MOLM-13 cell. |
|
| DC5083 |
Cinacalcet (AMG-073) HCl
Featured
|
AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism. |
|
| DC8514 |
AMG-1
Featured
|
AMG-1 is a potent inhibitor of human c-Met and RON with IC50 values of 4 and 9 nmol/L respectively. |
|
| DC7056 |
AMG-208
Featured
|
AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM. |
|
| DC8845 |
AMG337
Featured
|
AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays. |
|
| DC10101 |
AMG-3969
Featured
|
AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC 50 of 4 nM. |
|
| DC7001 |
AMG-47a
Featured
|
AMG-47a is a potent inhibitor of Lck and T cell proliferation; exhibits anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. |
|
| DC20664 |
AMG-548
Featured
|
AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ; shows >1,000-fold selectivity over other 36 kinases, and is efficacious in acute and chro |
|
| DC10132 |
AMG9810
Featured
|
AMG9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). |
|
| DC8503 |
AMG-Tie2-1
Featured
|
AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC50 <1 nM). |
|
| DC8292 |
AMI-1
Featured
|
AMI-1 is a PRMT and HIV-1 RT polymerase inhibitor. |
|
| DC20178 |
Pyrrolidinedithiocarbamate ammonium;APDC, PDTC
Featured
|
Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines. |
|
| DCAPI1343 |
Amorolfine HCl
Featured
|
Amorolfine hydrochloride is a antifungal reagent. |
|
| DC10698 |
Amoscanate
Featured
|
Amoscanate(nithiocyamine) is an experimental anthelmintic agent of the arylisothiocyanate class which was found to be highly effective in animals against the four major species of schistosomes which infect humans,and is also highly active against hookworm |
|
| DC5075 |
BDP-12(Ampalex)
Featured
|
Ampalex (Ampakine CX516) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). |
|
| DC11129 |
AMPK activator SC4
Featured
|
AMPK activator SC4 is a highly specific and potent activator of the α2β2-AMPK complexes, which are the predominant AMPK isoform complexes found in human skeletal muscle. SC4 demonstrates significant efficacy with EC50 values of 17.2 nM for the α2β2γ1 complex and 82.1 nM for the α2β2γ3 complex. These low EC50 values indicate that SC4 is effective at relatively low concentrations, making it a promising compound for targeting AMPK in skeletal muscle. This specificity and potency suggest potential therapeutic applications in conditions where AMPK activation is beneficial, such as metabolic disorders, muscle function, and energy homeostasis. |
|
| DC11274 |
AMPPD
Featured
|
AMPPD, 1,2-dioxo-cyclohexane derivatives, is a new biochemistry ultrasensitive alkaline phosphatase substrate. |
|
| DC7058 |
Amprenavir
Featured
|
Amprenavir (Agenerase) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection. |
|
| DC7324 |
Amuvatinib (MP-470)
Featured
|
Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. |
|
| DC25088 |
Rivastigmine
Featured
|
An acetylcholinesterase (AChE) inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase. |
|
| DC11651 |
HLY-78
Featured
|
HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1]. |
|
| DC23227 |
N6-Cyclohexyladenosine
Featured
|
An adenosine A1 receptor agonist (EC50= 8.2 nM).. |
|
| DC11657 |
PPT(Propyl pyrazole triol )
Featured
|
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%). |
|
| DC24145 |
G-418 disulfate
Featured
|
An aminoglycoside antibiotic similar in structure to gentamicin B1. |
|
| DC24054 |
Poloxime
Featured
|
An analog of thymoquinone that blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic.. |
|
| DC26076 |
D-Ala2, D-Leu5-Enkephalin
Featured
|
An angiotensin II analog that is an agonist of AT1 angiotensin receptor.. |
|
| DC22604 |
Anisomycin
Featured
|
An antibiotic that inhibits eukaryotic protein synthesis by inhibiting peptidyl transferase or the 80S ribosome system. |
|
| DC25077 |
Naphthoquine phosphate
Featured
|
Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia, including resistance of P. falciparum to Chloroquine. |
|
| DC10594 |
Tolcide 2230
Featured
|
An antimicrobial agent used as a substitute for chlorophenols |
|
| DC22497 |
MMAF-OMe
Featured
|
MMAF-Ome belongs to ADC, and inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. |
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