| DC46193 |
BRM/BRG1 ATP Inhibitor-1
Featured
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BRM/BRG1 ATP Inhibitor-1 is an orally active inhibitors of Brahma Homolog (BRM)/SMARCA2 with IC50 below 0.005 µM. |
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| DC57020 |
Avatrombopag
Featured
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Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 may be useful in the treatment of patients with thrombocytopenia. |
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| DC60055 |
NB-598
Featured
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NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. NB-598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB-598 suppressed the basolateral secretion of apolipoprotein (apo) B. When microsomes prepared from control Caco-2 cells were incubated with 10 microM NB-598, acyl CoA:cholesterol acyltransferase (ACAT) activity was inhibited slightly. |
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| DC60057 |
DUN73423
Featured
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DUN73423 is a RET/KDR-Selective Inhibitor of RETV804M Kinase with IC50 = 7 nM. DUN73423 was listed in ACS Med Chem Lett . 2020 Feb 28;11(4):497-505 (compound 5). DUN73423 has CAS#2414373-42-3, no formal name For the convenience of scientific communication, we named it as DUN73423 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature .
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| DC60058 |
Gly-AMC HCl
Featured
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Gly-AMC, also known as L-Gly-7-Amino-4-Methylcoumarin, is a probe and chromphore substrate for aminopeptidase. it is useful to make the C-terminal conjugate of ubiquitin with 7-amino-4-methylcoumarin (Ub-AMC), which is an important probe for fluorescence-based anal. of deubiquitinating enzyme (DUB) activity.
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| DC60059 |
Capmatinib hydrochloride
Featured
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Capmatinib, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor INC280 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. Capmatinib was approved in 2020.
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| DC60060 |
PTN57491
Featured
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PTN57491 is an key intermediate chemical to synthesize antiviral drugs remdesivir and GS441524. PTN57491 has CAS#1355357-49-1, has no formal name For the convenience of scientific communication, we named it as PTN57491 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature .
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| DC60061 |
Mefentrifluconazole
Featured
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Mefentrifluconazole is a fungicide on cereals.
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| DC60062 |
5-Hydroxymethyl-2'-deoxyuridine
Featured
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5-Hydroxymethyldeoxyuridine is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM).
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| DC60063 |
LUN42518
Featured
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LUN42518, also known as Phentolamine Analogue 1, is an analogue of phentolamine. Phentolamine is a nonselective alpha-adrenergic antagonist. LUN42518 has CAS#47142-51-8, no formal name For the convenience of scientific communication, we named it as LUN42518 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature.
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| DC60064 |
MW-2474
Featured
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MW-2474 is an inhibitor of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agent.
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| DC57050 |
DZD9008
Featured
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DZD9008 is an oral, potent, irreversible, wild type-selective EGFR TKI against EGFR or HER2 Exon20ins and other mutations. |
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| DC60065 |
Antrodin A
Featured
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Antrodin A, also known as Camphorataanhydride A, is one of the main active ingredients in the solid-state fermented A. camphorata mycelium. It protects the liver from alcohol damage by improving the antioxidant and anti-inflammatory capacity of the liver and maintaining the stability of the intestinal flora.a natural product from mycelium of Antrodia camphorata. Antrodin A alleviates acute alcoholic liver injury and modulates intestinal flora dysbiosis in mice.
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| DC60066 |
3'-O-Methylguanosine
Featured
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3'-O-Methylguanosine, also known as 3-OMG, is a methylated nucleoside analog and a RNA chain terminator. Early virus-specific RNA synthesis was preferentially inhibited by 3'-O-methyl guanosine.
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| DC60068 |
PD-123319 free base
Featured
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PD-123319 is a selective, nonpeptide AT2R antagonist (IC50 = 5.6 nM vs. 100 nM for AT1R). PD-123319 has been used to selectively examine the specific roles for AT1R and AT2R in hypertensive and other vascular research-related models.. |
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| DC60069 |
Sulfaproxyline
Featured
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Sulfaproxyline is antibiotics. |
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| DC60070 |
Benclonidine
Featured
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Benclonidine is an Antihypertonic agent.
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| DC60071 |
Prothixene
Featured
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Prothixene is a biochemical.
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| DC60072 |
MM-102 TFA
Featured
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MM-102 is a Potent WDR5/MLL interaction inhibitor. The MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5) and results in the inhibition of MLL1 H3K4 histone methyltransferase (HMT) activity. Down-Regulation of H3K4me3 by MM-102 Facilitates Epigenetic Reprogramming of Porcine Somatic Cell Nuclear Transfer Embryos
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| DC60073 |
YUM08164
Featured
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YUM08164 is a bioactive chemical. YUM08164 has CAS#1333608-16-4, no formal name. For the convenience of scientific communication, we named it as YUM08164 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature.
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| DC60074 |
LVN84663
Featured
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LVN84663 is a useful reagent for determination of blood coagulating protease. It was first described in patent DE 3516579. LVN84663 has CAS#103784-66-3, no formal name. For the convenience of scientific communication, we named it as LVN84663 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature
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| DC57035 |
Rineterkib(ERK-IN-1;compound B)
Featured
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Rineterkib, also known as LTT-462 or ERK-IN-1, is a RAF and ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models. LTT462 binds to and inhibits ERK, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in numerous tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. |
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| DC60075 |
OUN67600(TRPV4 agonist-1)
Featured
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OUN67600, is a Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonist as Regulators of Chondrogenic Differentiation. OUN67600 was first reported by Atobe et al (compound 36 in J Med Chem. 2019 Feb 14;62(3):1468-1483). OUN67600 has CAS#2314467-60-0, no formal name. For the convenience of scientific communication, we named it as OUN67600 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature.
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| DC60076 |
DEPC
Featured
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DEPC, also known as DC22:1PC or SJN79954, is a phospholipid containing erucic acid at the sn-1 and sn-2 positions. DEPC is a useful reagent in drug formulation study. It has been used in the study of lipid membranes and to determine the effect of long-chain phospholipids on the secondary structure of human islet amyloid polypeptide (hIAPP).
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| DC60077 |
JUN76288
Featured
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JUN76288, also known WEE1-IN-3, is a potent WEE1 kinase inhibitors useful in treatment of cancer and other proliferative diseases. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature |
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| DC60078 |
GUN94110
Featured
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GUN94110 is a WEE1 kinase inhibitors useful in treatment of cancer and other proliferative diseases. GUN94110 was reported in WO 2019028008. This product has no formal name at the moment. |
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| DC60079 |
Violanthrone-79
Featured
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Violanthrone-79 is an n-channel organic semiconductor.
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| DC60080 |
Micafungin
Featured
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Micafungin, also known as FK463, is a polyene antifungal medication used to treat and prevent invasive fungal infections including candidemia, abscesses and esophageal candidiasis. It inhibits the production of beta-1,3-glucan, an essential component of fungal cell walls. It received final approval from the U.S. Food and Drug Administration (FDA) on March 16, 2005. Micafungin works by way of concentration-dependent inhibition of 1,3-beta-D-glucan synthase resulting in reduced formation of 1,3-beta-D-glucan, which is an essential polysaccharide comprising one-third of the majority of Candida spp. cell walls. This decreased glucan production leads to osmotic instability and thus cellular lysis.
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| DC60081 |
IL-1R antagonist(TLR1)
Featured
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IL-1R antagonist, is a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88) that changes the interaction of MyD88 and IL-1 receptor type I (IL-1RI). This product has not formal name. |
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| DC60082 |
L-Leucine-13C6
Featured
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L-LEUCINE-13C6, also known as 13C6-D-Leucine or L-Leucine-1,2,3,4,5,5'-13C6, is a fully 13C labelled D-Leucine
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