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Cat. No. Product name CAS No.
DC8139 GMX1778(CHS-828) Featured

CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.

200484-11-3
DC2088 CI-1040 (PD184352) Featured

CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM.

212631-79-3
DC21463 CI-976 Featured

CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM.

114289-47-3
DC2060 CI994 (Tacedinaline) Featured

CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM.

112522-64-2
DC12285 CID 1375606 Featured

CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27.

313493-80-0
DC10873 CID16020046 Featured

CID 16020046 is a potent and selective GPR55(LPI receptor) antagonist; inhibitsGPR55 constitutive activity with IC50 of 0.15 uM.

834903-43-4
DC7253 CID-2011756 Featured

CID-2011756 is a cell-active ATP competitive and specific PKD1 inhibitor that inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate cancer cells.

638156-11-3
DC8849 CID-2858522 Featured

CID-2858522 is a selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production).

758679-97-9
DC9955 BCL6 inhibitor(CID5721353) Featured

CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor).

301356-95-6
DC7385 CID-755673 Featured

CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM; exhibits selective PKD1 inhibition when compared with AKT, PLK1, CAK, CAMKIIα, and PKC isoforms.

521937-07-5
DC7976 CID 797718 Featured

CID-797718 is a compound with unknown details.

370586-05-3
DCAPI1021 Cidofovir(Vistide) Featured

Cidofovir(Vistide)

113852-37-2
DC10839 CIL56(CA3) Featured

CIL56 is a small molecule that induces cellular ferroptosis through production of iron-dependent reactive oxygen species (ROS).

300802-28-2
DC9325 Cilazapril (monohydrate) Featured

Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

92077-78-6
DC7561 Cilengitide (TFA salt) Featured

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.

199807-35-7
DC9875 Ciliobrevin A(HPI4) Featured

Ciliobrevin A(HPI-4) is a Hedgehog pathway inhibitor and ciliogenesis inhibitor.

302803-72-1
DC20341 Ciliobrevin D Featured

Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of cytoplasmic dynein, blocks dynein-dependent microtubule gliding and ATPase activity while sparing kinesin dependent cellular trafficking.

1370554-01-0
DC9160 Cilnidipine Featured

Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.

132203-70-4
DC10868 Cilofexor Featured

Cilofexor (GS-9674, GS9674) is novel specific, non-steroidal farnesoid X receptor (FXR) agonist that reduces liver fibrosis and ameliorates portal hypertension in rat NASH models.

1418274-28-8
DC8801 Cinacalcet (AMG-073) Featured

Cinacalcet(AMG-073) is an orally active, second-generation calcimimetic compound; AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism.

226256-56-0
DC12369 Cinaciguat (hydrochloride) Featured

Cinaciguat is an activator of sGC that binds to a regulatory site, resulting in activation in an NO-independent manner (Kd = 3.2 nM).

646995-35-9
DC20093 Cinchonine ((8R,9S)-Cinchonine; LA40221) Featured

Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells.

118-10-5
DC9896 Cinnarizine Featured

Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.

298-57-7
DCH-062 Cinobufotalin Featured

Cinobufotalin is a steroid glycoside originally isolated from the Asiatic toad (B. gargarizans) and has diverse biological activities.

1108-68-5
DC22295 Cintirorgon sodium Featured

Cintirorgon (LYC-55716) is novel oral RAR-related orphan receptor γ (RORγ) agonist.

2055538-47-9
DC22329 Cintirorgon Featured

Cintirorgon (LYC-55716) is novel oral RAR-related orphan receptor γ (RORγ) agonist.

2055536-64-4
DCAPI1372 Ciprofloxacin (Cipro) Featured

Ciprofloxacin (Bay-09867) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

85721-33-1
DC2062 Ciproxifan (FUB-359) Featured

Ciproxifan is an antagonists of H3-type histamine receptors.

184025-18-1
DC9466 Ciproxifan (maleate) Featured

Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

184025-19-2
DC8156 CIQ Featured

CIQ is a positive allosteric modulator selective for NR2C/D containing NMDA receptors (EC50 = 2.7 and 2.8 µM for NR2C and NR2D, respectively).

486427-17-2
DC8187 Ciraparantag(PER977) Featured

Ciraparantag(PER977) is an intravenously administered anticoagulant Reversal Agent.

1438492-26-2
DCAPI1600 Cisapride Featured

Cisapride is a SR-4 agonist also known as Enteropride

81098-60-4
DC9517 Cisatracurium (besylate) Featured

Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.

96946-42-8
DC2099 cis-Diaminedichloroplatinum Featured

Cisplatin is an inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity.

15663-27-1
DC12668 Citarinostat(ACY-241) Featured

Citarinostat(ACY-241) is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity.

1316215-12-9
DC20906 CJ-13610 Featured

CJ-13610 is a potent 5-Lipoxygenase (5-LO) inhibitor that suppresses 5-LO product formation with IC50 of 70 nM.

179420-17-8
DC20907 CK 666 Featured

CK 666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM, inhibits actin polymerization with either BtArp2/3 complex (IC50=17 uM) or SpArp2/3 complex (IC50=5 uM).

442633-00-3
DC11673 CK-2127107 Featured

CK-2127107(CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.

1345410-31-2
DC7386 CK-636 Featured

CK-636(CK-0944636) is a small molecule inhibitor of Arp2/3 complex; Inhibitor of actin polymerization; Cell permeable inhibitor of human (IC50=4μM), fission yeast (IC50=24μM) and bovine (IC50=32μM) Arp2/3 complex between Arp2 and Arp3.

442632-72-6
DC11475 CK-869 Featured

CK-869 is an inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex.

388592-44-7
DC12595 CL27c Featured

CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay, once inside the cytoplasm, CL27c is metabolized by unspecific esterases into CL27e.

1380227-11-1
DC7668 CL-387785 Featured

CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.

194423-06-8
DC12292 Cl-amidine hydrochloride Featured

Cl-amidine (hydrochloride) is a peptidylarginine deminase (PAD) inhibitor, with an IC50 5.9 μM for PAD4.

1373232-26-8
DC9725 Cl-amidine Featured

Cl-amidine is a cell-permeable compound that acts as a pan PAD inhibitor (IC50 = 0.8 µM, 6.2 µM and 5.9 µM for PAD1, PAD3, and PAD4, respectively) in enzymatic assays.

1043444-18-3
DC9868 Clanfenur Featured

Clanfenur is a substituted benzoylphenylurea and an analogue of the pesticide diflubenzuron with potential antineoplastic activity.

51213-99-1
DC7387 Clemizole Hydrochloride Featured

Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.

1163-36-6
DC8832 Clemizole (free base) Featured

Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.

442-52-4
DC9380 Cleviprex Featured

Clevidipine(Clevidipine) is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.

167221-71-8
DCAPI1085 Clevudine (Levovir) Featured

Clevudine (Levovir) is an antiviral drug for the treatment of hepatitis B,showed potent activity against COVID-19(SARS-COV-2) .

163252-36-6
DC21722 CLK-IN-T3 Featured

CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110 nM for CLK1,2 and 3, respectively.

2109805-56-1
DCAPI1428 Clofarabine Featured

Clofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. IC50 Value: 65 nM Target: in vitro: Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It

123318-82-1
DC7991 8-​Chloro-​11-​(4-​methyl-​1-​piperazinyl)​-​5H-​dibenzo[b,e]​(1,4)​diazepine N-oxide Featured

Clozapine N-oxide is a major metabolite of Clozapine noted to decrease SR-2A (5-HT2 serotonin receptor) density in vitro.

34233-69-7
DC12714 CLP-290 Featured

CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257; In vivo co-treatment with morphine and oral CLP290 prevented membrane KCC2 downregulation in SDH neurons. Concurrently, co-treatment with CLP290 significantly mitigated MIH and acute administration of CLP257 in established MIH restored normal nociceptive behavior.

1181083-81-7
DC9797 18-[4-(2,2-Difluoro-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-8-yl)phenyl]octadecyl-[2-(trimethylazaniumyl)ethoxy]phosphinate Featured

CLR1501 is a synthetic analogs of the tumor-targeting agent alkylphosphocholine (APC), which is specifically attracted to cancer cells.

1250963-36-0
DC10795 CM-272 Featured

CM-272 is a first-in-class reversible dual small molecule inhibitor against G9a and DNMTs in hematological malignancies.

1846570-31-7
DC7605 CM346(Afobazole) Featured

CM-346 increased the power of the low-frequency θ-rhythm (4.8–5.8 Hz) and the dominant activity peak (6.0–7.2 Hz) and decreased the spectral power in the 19–20 Hz band.

173352-21-1
DC21530 CMP-5 Featured

CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.

880813-42-3
DC9803 CMP8 Featured

CMP8 is a high-affinity ligand that binds only to mutant ERLBD.

851107-28-3
DC22512 CMPDA Featured

CMPDA is a potent positive allosteric modulator of GluR2 receptors with EC50 of 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assays.

380607-77-2
DC7761 Brincidofovir (CMX-001) Featured

CMX001 (Brincidofovir; HDP-CDV) was developed as an orally active, lipophilic form of cidofovir (CDV); has enhanced activity in vitro and in vivo compared to CDV against certain herpesviruses, adenoviruses and orthopoxviruses.IC50 Value: 5.5 nM (EC50, in PDA at 7 dpi) [3]Target: anti-CMVCMX001 is currently in Phase II clinical studies for development as a therapeutic agent for human CMV, adenovirus and BK virus infections, as well as, for adverse events following smallpox vaccinations.in vitro: In PDA at 7 dpi, the CMX001 50% effective concentration (EC50) was 5.55 nM, the 50% cytotoxic concentration (CC50) was 184.6 nM, and the 50% selectivity index (SI50) was 33.3. The EC90 was 19.7 nM, the CC90 was 5,054 nM, and the SI90 was 256.1. In COS-7 cells, JCV replication was faster and the EC50 and EC90 were 18- and 37-fold higher than those in PDA, i.e., 0.1 μM and 0.74 μM (CC50, 0.67 μM; SI50, 6.7; CC90, 12.2 μM; SI90, 16.5) at 5 dpi [3].in vivo: CMX001 and CDV are equally efficacious at protecting mice from mortality following high ectromelia virus doses (10,000 x LD(50)) introduced by the intra-nasal route or small particle aerosol. Using CMX001 at a 10mg/kg dose followed by 2.5mg/kg doses every other-day for 14 days provided solid protection against mortality and weight loss following an intra-nasal challenge of (100-200) x LD(50) of ectromelia virus [1]. When CMX001 was administered orally to mice infected with HSV-1, mortality was reduced significantly (p≤0.001) with all three dose levels when treatments were initiated 24 h post viral inoculation. When treatments were started 48 h post viral inoculation, 5 and 2.5 mg/kg significantly reduced mortality (p≤ 0.001). If treatments were delayed until 72 h post viral inoculation, CMX001 did not reduce mortality or increase the mean day to death. When mice were infected intranasally with HSV-1 and treatments initiated 24 h post viral inoculation using CMX001 at 5 mg/kg or ACV at 100 mg/kg, virus replication in target organs was reduced by both CMX001 and ACV when compared to vehicle treated mice [2]. Toxicity: Diarrhea was the most common adverse event in patients receiving CMX001 at doses of 200 mg weekly or higher and was dose-limiting at 200 mg twice weekly. Myelosuppression and nephrotoxicity were not observed [4].

444805-28-1
DC12476 CN427 Featured

CN427 (CN-427) is novel BRD4 (BD1, 2) inhibitor with IC50 of 66 nM, MV4-11 viability IC50 of 1.1 uM..

DC10752 CNDAC HCl Featured

CNDAC (DFP-10917; TAS-109) is an orally available deoxycytosine nucleoside analog with potential antineoplastic activity.

134665-72-8
DC9799 CNDAC Featured

CNDAC is the active component of sapacitabine.

135598-68-4
DC10671 CNQX disodium salt Featured

CNQX is a potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex.

479347-85-8
DC10670 CNQX Featured

CNQX is a potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex.

115066-14-3
DC23180 CNV1014802(Raxatrigine) Featured

CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine, BIIB074) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo.

934240-30-9
DC8095 Raxatrigine hydrochloride Featured

CNV1014802(GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.

934240-31-0
DC7105 CNX-2006 Featured

CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.

1375465-09-0
DC7161 CNX-774 Featured

CNX-774 is a potent, selective, and orally available small molecule inhibitor of Btk (IC50< 1 nM) that forms a ligand-directed covalent bond with Cys-481, a non-conserved amino acid within the active site of the enzyme.

1202759-32-7
DC8651 CO-1686 hydrobromide Featured

CO-1686 hydrobromide is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M (IC50=21 nM).

1446700-26-0
DC7106 Rociletinib (CO-1686) Featured

CO-1686 is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M(IC50=21 nM).

1374640-70-6
DC2046 Cobicistat (GS-9350) Featured

Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.

1004316-88-4
DC8863 Coelenterazine Featured

Coelenterazine is a luminescent enzyme substrate, used for monitoring reporter genes in BRET, ELISA and HTS techniques.

55779-48-1
DC10336 Coenzyme Q9 Featured

Coenzyme Q9, a nine isoprenyl group-containing member of the ubiquinone family, is a normal constituent of human plasma.

303-97-9
DC11955 Takeda compound 101 Featured

Compound 101 (GRK2 inhibitor 101, Takeda compound 101, Cmpd101) is a novel membrane-permeable, small-molecule inhibitor of GRK2 and GRK3.

865608-11-3
DC2085 Compound 401 Featured

Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over FRAP (mTOR) (IC50 = 5.3 µM).

168425-64-7
DC8340 myo-Inositol,1,2-anhydro- Featured

Conduritol B Epoxide (CBE) is a specific covalent inhibitor of β-glucosidase which results in the accumulation of glucocerebroside.

6090-95-5
DCAPI1091 Conivaptan hydrochloride Featured

Conivaptan(YM 087) is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist) with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively.

168626-94-6
DC8477 VER-49009 Featured

Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.

558640-51-0
DC10776 Cordycepin Featured

Cordycepin is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities.

73-03-0
DC12098 Corin Featured

Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.

1808113-09-8
DC11104 Tildacerfont Featured

corticotropin releasing factor (CRF) antagonist.

1014983-00-6
DC22488 Corticotropin-releasing factor (human) Featured

Corticotropin-releasing hormone (CRH) is a peptide hormone involved in the stress response..

86784-80-7
DC23908 Cortisone Featured

Cortisone is a pregnane (21-carbon) steroid hormone, one of the main hormones released by the adrenal gland in response to stress.

53-06-5
DC10686 Cosan-528 Featured

Cosan-528 is a bioactive chemical.

96686-51-0
DC10657 COTI-2 Featured

COTI-2 is a small molecule candidate anti-cancer drug which can convert mutant p53 to wild-type conformation.

1039455-84-9
DC10363 Coumestrol Featured

Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.

479-13-0
DC10528 CP 376395 Featured

CP 376395 is a potent and selective CRF1 receptor antagonist (Ki values are 12 and >10000 nM for CRF1 and CRF2 receptors respectively).

175140-00-8
DC7389 CP-673451 Featured

CP 673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.

343787-29-1
DC12046 CP 105696 Featured

CP-105696 is a potent and selective Leukotriene B4 Receptor antagonist, with an IC50 of 8.42 nM.

158081-99-3
DC9726 CP21 (CP21R7) Featured

CP21R7 is a potent and selective GSK-3β inhibitor.

125314-13-8
DC23320 CP 31398 dihydrochloride Featured

CP-31398 is a small molecule p53 reactivator that protects p53 from thermal denaturation, not only reactivates mutant p53 but also induces stabilization of wild type p53.

1217195-61-3
DC23610 CP-339818 hydrochloride Featured

CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM.

478341-55-8
DC4112 CP466722 Featured

CP-466722 is an potent and reversible ATM inhibitor.

1080622-86-1
DC9303 Taprenepag(CP-544326) Featured

CP-544326 is a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma.

752187-80-7
DC4132 CP-547632 Featured

CP-547632 is as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively).

252003-65-9
DC9265 CP-640186 hydrochloride Featured

CP-640186 Hcl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431.

591778-70-0
DC7975 CP 640186 Featured

CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

591778-68-6
DC11410 CP-671305 Featured

CP-671305 is a potent and selective inhibitor of phosphodiesterase 4.

445295-04-5
DC10506 CPHPC(Miridesap) Featured

CPHPC(GSK2315698,Miridesap) is a divalent crosslinker of SAP that causes rapid depletion of circulating SAP via hepatic clearance.

224624-80-0
DC7564 CPI 0610(Pelabresib) Featured

CPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay.

1845726-14-8
DC9736 CPI1189(REN-1189) Featured

CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex.

183619-38-7
DC8001 CPI 169 R-enantiomer Featured

CPI-169 R is a novel and potent EZH2 inhibitor with IC50 <1 nM(inhibition of the catalytic activity of PRC2.

DC8466 CPI-169 (racemate) Featured

CPI-169 racemate is the racemate form of CPI-169, which is a novel and potent EZH2 inhibitor with IC50 <1 nM(inhibition of the catalytic activity of PRC2); decreases cellular levels of H3K27me3 with an EC50 of 70 nM, and triggers cell cycle arrest and apo

1450655-76-1
DC5046 CPI203 (CPI-203) Featured

CPI203 is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~37 nM (BRD4 α-screen assay).

1446144-04-2
DC8619 CPI-268456 Featured

CPI-268456 is a potential BET bromodomain inhibitor.

1380087-86-4
DC8002 CPI-360 (R) Featured

CPI-360 is a compound in design and preparation of wew palladium precatalysts for C-C and C-N cross-coupling reactions.

1802175-06-9
DC10527 Ciforadenant (CPI-444) Featured

CPI-444 is an orally administered antagonist of the adenosine A2A receptor. It is designed to block the action of adenosine that is produced by tumors.

1202402-40-1
DC10593 CPI-455 analogue(KDM5 inhibitor) Featured

CPI-455 analogue is a selective inhibitor of KDM5 demethylases.

DC9858 CPI-455 Featured

CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents.

1628208-23-0
DC10591 CPI-613 Featured

CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer.

95809-78-2
DC10477 CPI-637 Featured

CPI-637 is a potent and selective CBP/EP300 bromodomains inhibitor with IC50 of 0.03±0.01μM and 11.0±0.6 μM for CBP/EP300 and BRD4, respectively.

1884712-47-3
DC9508 CPPHA Featured

CPPHA is a selective positive allosteric modulator of mGluR5 receptor.

693288-97-0
DC23765 CPYPP Featured

CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction.

310460-39-0
DC12396 CR4056 Featured

CR4056 (CR 4056, CR-4056) is a novel, orally active imidazoline-2 receptor (I2R) ligand with binding IC50 of 596 nM, also selectively inhibits the enzymatic activity of MAO-A with IC50 of 202.7 nM; increases norepinephrine (NE) tissue levels both in the rat cerebral cortex and lumbar spinal cord, shows ED50 of 5.8 mg/kg in CFA rat model of inflammatory pain; shows high effectivity against bortezomib-induced painful neuropathy in rats.

1004997-71-0
DC11380 Difelikefalin (CR845) Featured

Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2].

1024828-77-0
DC20347 Crebinostat Featured

Crebinostat is a novel cognitive enhancer that inhibits class I HDAC/1/2/3 (IC50=0.7/1.0/2.0 nM), class IIb HDAC6 (IC50=9.3 nM) with weaker inhibition of the class I HDAC8 and no significant inhibition of the class IIa HDAC/4/5/7/9; potently induces acetylation of both histone H3 and histone H4 as well as enhanced the expression of the CREB target gene Egr1 in cultured mouse primary neurons; upregulates Bdnf and Grn, and downregulates Mapt (tau) gene expression-genes; brain penetrant.

1092061-61-4
DC5159 CP-868596 (Crenolanib) Featured

Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB

670220-88-9
DC11642 Cridanimod sodium Featured

Cridanimod sodium is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.

58880-43-6
DC22634 Crizotinib hydrochloride Featured

Crizotinib (PF-02341066;PF-2341066) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of c-Met catalytic activity with Ki of 4 nM.

1415560-69-8
DC20999 CS-3150 (Esaxerenone;XL-550) Featured

CS-3150 (Esaxerenone, XL-550) is a highly potent, selective and orally active non-steroidal mineralocorticoid receptor antagonist with IC50 of 9.4 nM; displays >1,000-fold selectivity over other steroid hormone receptors, glucocorticoid receptor, androgen receptor and progesterone receptor; inhibits aldosterone-induced transcriptional activation of human mineralocorticoid receptor with IC50 of 3.7 nM, shows superior potency to that of spironolactone and eplerenone; suppresses aldosterone-induced decrease in urinary Na(+)/K(+) ratio, inhibits blood pressure elevation induced by DOCA/salt-loading in rats.

1632006-28-0
DC20089 CSF1R-IN-1 Featured

CSF1R-IN-22 is a potent, cellular active and orally bioavailable CSF1R inhibitor with IC50 of 0.5 nM, displays 120-fold selectivity over c-Kit; has improved metabolic stability and Caco2 permeability.

2095849-04-8
DC22209 CSLP37 Featured

CSLP37 (RIPK2 inhibitor CSLP37) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 16.3 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling.

2244984-64-1
DC12576 CSRM617 Featured

CSRM617 (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly.

787504-88-5
DC12661 CT1812 Featured

CT 1812 is a proprietary first-in-class, orally available sigma-2/PGRMC1 antagonist (alpha beta oligomer receptor antagonist

1802632-22-9
DC7110 CTEP Featured

CTEP is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM.

871362-31-1
DC11217 SLC25A1 inhibitor CTPI-2 Featured

CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo; disrupts self-renewal and

68003-38-3
DC7904 CTX0294885 Featured

CTX-0294885 is a novel broad-spectrum kinase inhibitor.

1439934-41-4
DC10771 CU-CPT-8m Featured

CU-CPT-8m is a nolve TLR8 inhibitor.

125079-83-6
DC10769 CU-CPT-9b Featured

CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).

2162962-69-6
DC10770 CU-CPT-9a Featured

CU-CPT9a is an antagonist of toll-like receptor 8 (TLR8). It inhibits activation of NF-κB induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells (IC50 = 0.5 nM). CU-CPT9a reverses R-848-induced increases in NF-κB p65, IRAK-4, and TRAF3 protein levels in HEK-Blue cells.

2165340-32-7
DC9282 cucurbitacin B Featured

Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from Cucurbitaceae plant species, is a long-term anticancer agent by disruption of microtubule polymerization.

6199-67-3
DC23035 Curcurbitacin IIa Featured

Cucurbitacin IIa has anti-cancer, anti-bacterial, and anti-inflammatory effects, it can induce apoptosis and enhance autophagy; it also can disrupt the actin cytoskeleton and direct the cell to undergo PARP-mediated apoptosis through the inhibition of sur

58546-34-2
DC7544 CUDC-101 Featured

CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1.

1012054-59-9
DC9699 CVM-1118(CVM1118) Featured

CVM-1118(CVM1118) has high anti-cancer activity, good safety margin, and multiple mechanisms of action targeting cancer, especially its unique ability to inhibit vasculogenic mimicry (VM).

1256037-58-7
DC7391 CVT-10216 Featured

CVT-10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively).

1005334-57-5
DC9306 CVT-313(NG-26) Featured

CVT-313(NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 215 uM for Cdk4/D1).

199986-75-9
DC7392 CW069 Featured

CW-069 is a novel and allosteric inhibitor of the microtubule motor protein HSET with IC50 value of 75 ± 20 μM; shows statistically significant selectivity over KSP.

1594094-64-0
DC9278 CWHM-12 Featured

CWHM-12 a novel small molecule inhibitor of αV integrins with IC50s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8; less potency on αvβ5(IC50=61 nM) and on inhibition on αIIbβ3/α2β1/α10β1.

1564286-55-0
DC7111 CX-4945 (Silmitasertib) Featured

CX-4945 (Silmitasertib) is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2α, respectively.

1009820-21-6
DC23942 CX-4945 sodium salt(Silmitasertib) Featured

CX-4945 Sodium Salt is a water soluble CX-4945 (GLXC-04060), First-in-class Casein kinase 2 (CK2) inhibitor, sequentially attenuating the proteins in PI3K/Akt and MAPK pathways.

1309357-15-0
DC24074 CX-546 Featured

CX546 is an AMPA receptor potentiator and GluR activator, binds specifically to the agonist bound non-desensitized receptor.

215923-54-9
DC7810 CX-5461 Featured

CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA, has no effect on Pol II, and possesses 250-to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.

1138549-36-6
DC7153 CX6258 Featured

CX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity.

1202916-90-2
DC9925 CXD101(AZD-9468) Featured

CXD101(AZD-9468) is a novel histone deacetylase (HDAC) inhibitor with potential antineoplastic activity.

934828-12-3
DC10620 CY-09 Featured

CY-09 is an NLRP3 inhibitor.

1073612-91-5
DC10576 Cyantraniliprole Featured

Cyantraniliprole(HGW-86) is an insecticide of the ryanoid class; has activity against pests such as Diaphorina citri that have developed resistance to other classes insecticides.

736994-63-1
DC10442 Cyazofamid Featured

Cyazofamid is a foliar fungicide approved for use in the EU.

120116-88-3
DC10775 Fadraciclib (CYC065) Featured

CYC065 is an orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9) with potential antineoplastic and chemoprotective activities.

1070790-89-4
DC7325 CYC116 Featured

CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM.

693228-63-6
DC10541 Cyclo(RGDfC) Featured

Cyclo (RGDfC), avb3 Integrin Binding Cyclic RGD Peptide,This is a cyclic RGDfC sequence, an integrin avb3-affine peptide.

862772-11-0
DC26050 Cyclo(L-Pro-L-Val) Featured

Cyclo(L-Pro-L-Val) is a diketopiperazine that has been found in the marine sponge T. ignis, the bacterium B. pumilus, and the fungus A. fumigatus, among others.

2854-40-2
DC8055 Cyclo(-RGDfK) Featured

cyclo(-RGDfK,-Arg-Gly-Asp-D-Phe-Lys)) is a selective αvβ3-integrin antagonist.

161552-03-0
DC8399 Cyclo(RGDyK) Featured

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.

250612-42-1
DC11446 Cycloastragenol Featured

Cycloastragenol, the aglycone derivative of astragaloside A, can be found in various species of Astragalus and is reported to activate telomerase.

84605-18-5
DC9058 Cyclobenzaprine HCl Featured

Cyclobenzaprine Hcl is a skeletal muscle relaxant and a central nervous system (CNS) depressant.

6202-23-9
DCAPI1537 Flunixin Meglumine Featured

Cyclooxigenase inhibitor. Anti-inflammatory, analgesic and antipyretic.

42461-84-7
DC9910 CYCLOPAMINE Featured

Cyclopamine(11-Deoxojervine) is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.

4449-51-8
DC9013 Cyclophosphamide Featured

Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

50-18-0
DC4115 Cyclosporin A Featured

Cyclosporin A (Cyclosporine A) is an immunosuppressant agent widely used in post-allogeneic organ transplant to reduce the activity of the immune system.

59865-13-3
DCAPI1374 Cyclovirobuxin D(Bebuxine) Featured

Cyclovirobuxin D(Bebuxine)

860-79-7
DC10610 CycLuc1(Luciferase substrate) Featured

CycLuc1 is a luciferase substrate which offers brighter bioluminescence and improved imaging in mouse models at lower doses than the standard D-luciferin.

1247879-16-8
DC12469 CYH33 Featured

CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively.

1494684-28-4
DC8088 CYM5442 Featured

CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist.

1094042-01-9
DC3107 Momelotinib (CYT387,CYT-387) Featured

CYT387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 11 nM and 18 nM, respectively.

1056634-68-4
DC9835 Cytochalasin H Featured

Cytochalasin H is a potent inhibitor of actin incorporation into filaments,a cell-permeable fungal toxin used in actin polymerization studies and cytological research.

53760-19-3
DCAPI1566 Cytarabine hydrochloride Featured

Cytosine β-D-arabinofuranoside hydrochloride is an anti-leukemic agent which binds to topoisomerase I resulting in DNA fragmentation and inhibition of replication. In addition this compound does not have any effects on RNA synthesis. Cytosine β-D-arabinof

69-74-9
DC10125 CZ415 Featured

CZ415 is a potent and highly selective mTOR inhibitor.

1429639-50-8
DC7734 CZC24832 Featured

CZC24832 is the first selective PI3Kγinhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and >100-fold selectivity over PI3Kα and PI3Kδ.

1159824-67-5
DC7113 CZC-25146 Featured

CZC-25146 is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively.

1191911-26-8
DC8082 CZC-54252 Featured

CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively).

1191911-27-9
DC11199 CZh226 Featured

CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1.

2196199-00-3
DC12296 D-(+)-Trehalose dihydrate Featured

D-(+)-Trehalose dihydrate can be used as a food ingredient and pharmaceutical excipient.

6138-23-4
DC12252 D,L-Buthionine-(S,R)-sulfoximine Featured

D,L-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

5072-26-4
DC20219 D159687 Featured

D159687 is a selective negative allosteric modulator (NAM) of PDE4D.

1155877-97-6
DC9850 D-3263 HCl Featured

D3263 is a novel, orally bioavailable small molecule Trp-p8 agonist.

1008763-54-9
DC7011 D4476 (D-4476) Featured

D4476, a cell-permeant inhibitor of CK1δ (IC90 <10 uM), suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a, D4476 originally identified as inhibitors of activin receptor-like kinase ALK5.

301836-43-1
DC9589 D609 Featured

D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent.

83373-60-8
DC7393 D-64131 Featured

D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin.

74588-78-6
DC9259 DAA1106 Featured

DAA1106 is a potent and selective ligand for peripheral benzodiazepine receptors, in mitochondrial fractions of the rat brain.

220551-92-8
DC8913 Dabigatran etexilate mesylate Featured

Dabigatran etexilate mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.

872728-81-9
DC5149 Dabrafenib Featured

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Phase 3.

1195765-45-7
DC4103 Dabrafenib Mesylate Featured

Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity.

1195768-06-9
DC7182 Dacinostat (NVP-LAQ824, LAQ824) Featured

Dacinostat (NVP-LAQ824, LAQ824) is a highly potent HDAC inhibitor with IC50 of 32 nM.

404951-53-7
DC7394 Daclatasvir dihydrochloride (BMS-790052) Featured

Daclatasvir (BMS-790052) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture.

1009119-65-6
DC4197 Actinomycin D Featured

Dactinomycin (also known generically as Actinomycin D ) is the most significant member of actinomycines, which are a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces.

50-76-0
DC20353 Dafadine A Featured

Dafadine A is the first reported small-molecule DAF-9 cytochrome P450 inhibitor that robustly induces dauer formation in in the nematode Caenorhabditis elegans.

1065506-69-5
DC23077 Daidzin Featured

Daidzin is a potent, selective aldehyde dehydrogenase 2 (ALDH2,IC50 = 80 nM) inhibitor, which has antiallergic anti-oxidant, anti-carcinogenic, antithrombotic,and anti-atherosclerotic activities

552-66-9
DCAPI1493 Dalbavacin Featured

Dalbavancin, a semisynthetic lipoglycopeptide being developed for the treatment of skin and skin structure infections (SSSIs), has a half-life of 5 to 7 days in humans and offers promise for a convenient weekly dosing regimen.

171500-79-1
DC3163 Dalcetrapib (JTT-705) Featured

Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM.

211513-37-0
DC21881 Danicamtiv (MYK-491) Featured

Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.

1970972-74-7
DC11082 Danicopan (ACH-4471) Featured

Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM.

1903768-17-1
DC9689 Danirixin (GSK1325756) Featured

Danirixin(GSK1325756) is a selective CXCR2 antagonist.

954126-98-8
DC8238 Danoprevir Featured

Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A.

850876-88-9
DC4125 PHA-739358 (danusertib) Featured

Danusertib (PHA-739358) is an Aurora inhibitor for Aurora A/B/C, Bcr-Abl, c-RET and FGFR with IC50 of 13 nM/79 nM/61 nM, 25 nM, 31 nM and 47 nM, respectively.

827318-97-8
DC6904 DAPAGLIFLOZIN Featured

Dapagliflozin, also known as BMS-512148, is a drug used to treat type 2 diabetes approved in 2012 by FDA. Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2) which are responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter mechanism causes blood glucose to be eliminated through the urine. In clinical trials, dapagliflozin lowered HbA1c by 0.6 versus placebo percentage points when added to metformin.

461432-26-8
DC20170 Dapagliflozin propanediol monohydrate Featured

Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.

960404-48-2
DC20941 DAPH-1 Featured

DAPH-1 (CGP 52411) is a small molecule that directly inhibits prion protein Sup35 prionogenesis with IC50 of 0.58 uM, inhibits and reverses the formation of Aβ42 fibers and reduces their toxicity to neurons in culture.

145915-58-8
DC7395 Dapivirine Featured

Dapivirine(TMC 120, TMC 120 R147681) is a NNRTI for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates.

244767-67-7
DC9630 Dapoxetine (hydrochloride) Featured

Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor(SSRI).

129938-20-1
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