| DC48146 |
KUC-7322 |
KUC-7322, a selective β3 -adrenoceptor agonist, is the active form of ritobegron. Ritobegron decreases intravesical pressure with minimal effects on the cardiovascular system. |
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| DC48147 |
Azilsartan mepixetil |
Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A). |
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| DC48148 |
Azilsartan mopivabil |
Azilsartan mopivabil is the potent antagonist of angiotensin II receptor. |
|
| DC48149 |
Mepixetil |
Mepixetil is a potent antagonist of angiotensin II receptor. |
|
| DC48150 |
Mopivabil |
Mopivabil is the antagonist of angiotensin II receptor. |
|
| DC48151 |
Deucrictibant |
Deucrictibant is a potent bradykinin receptor antagonist. Bradykinin receptors are cell surface, G-protein coupled receptors of the seven-transmembrane domained family. |
|
| DC48152 |
Vicasinabin |
Vicasinabin is the potent agonist of cannabinoid receptor 2 (CB2). Vicasinabin has the potential for the research of human diseases including chronic pain, atherosclerosis, regulation of bone mass, neuroinflammation, and other related diseases (extracted from patent US20130116236A1). |
|
| DC48153 |
HTL22562 |
HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine. |
|
| DC48154 |
SUN B8155
Featured
|
SUN B8155, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis. |
|
| DC48155 |
Sibenadet hydrochloride |
Sibenadet hydrochloride (AR-C68397AA) is a dual D2 dopamine receptor, beta2-adrenoceptor agonist with bronchodilator activity. Investigation in animal models of key chronic obstructive pulmonary disease (COPD) symptoms has demonstrated that Sibenadet hydrochloride effectively inhibits sensory nerve activity, thereby reducing reflex cough, mucus production and tachypnoea. |
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| DC48156 |
Molindone |
Molindone ((±)-Molindone), an indole derivative, is a potent dopamine D2 and D5 receptor antagonist. Molindone ((±)-Molindone) can be used for the research of schizophrenia and severe mental illness. |
|
| DC48157 |
Raclopride |
Raclopride is a selective dopamine D2/D3 receptor antagonist that discriminates between dopamine-mediated motor functions. Raclopride binds to D2 and D3 receptors with dissociation constants of between 1.8 nM and 3.5 nM, but has a very low affinity for D4 receptors. |
|
| DC48158 |
Utreglutide |
Utreglutide is a potent glucagon-like peptide 1 (GLP-1) receptor agonit. |
|
| DC48159 |
Ecnoglutide |
Ecnoglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist. |
|
| DC48160 |
Masilukast |
Masilukast is an orally administered cysteinyl leukotriene D4 (LTD4) receptor antagonist with potential to treat asthma. |
|
| DC48161 |
MK-6884-11C |
MK-6884-11C is a positron emission tomography (PET) imaging agent for the study of M4 muscarinic receptor positive allosteric modulators (PAMs) in neurodegenerative diseases. |
|
| DC48162 |
Milameline |
Milameline is a muscarinic receptor agonist that improves cognition. |
|
| DC48163 |
Sabcomeline hydrochloride |
Sabcomeline (hydrochloride) is a potent and functionally selective muscarinic M1 receptor partial agonist that improve cognition. |
|
| DC48164 |
Aceclidine
Featured
|
Aceclidine is a modulator of M3 muscarinic acetylcholine receptor. Aceclidine is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia (extracted from patent US20150290125A1/US20110091459A1). |
|
| DC48165 |
Xanomeline tartrate |
Xanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia. |
|
| DC48166 |
Methoctramine tetrahydrochloride |
Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine tetrahydrochloride can inhibit Muscarine-induced bradycardia in vivo. |
|
| DC48167 |
Talaglumetad hydrochloride |
Talaglumetad hydrochloride is a prodrug of thetype II metabotropic glutamate receptor (mGluR2/3) agonist Eglumegad for the treatment of anxiety. |
|
| DC48168 |
Ro 67-4853 |
Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation. |
|
| DC48169 |
DS34942424
Featured
|
DS34942424 is an orally potent analgesic without mu opioid receptor agonist activity. |
|
| DC48170 |
Riminkefon |
Riminkefon is a kappa opioid receptor agonist. |
|
| DC48171 |
Tegileridine |
Tegileridine is the potent agonist of opioid receptor (MOR). Tegileridine is an oxa spiro derivative which reduces the side effects mediated by β-arrestin. Tegileridine has the potential for the research of pains and pains-related diseases (extracted from patent WO2017063509A1). |
|
| DC48172 |
BAY-6672
Featured
|
BAY-6672 is a potent and selective human Prostaglandin F (FP) receptor antagonist with an IC50 value of 11 nM. |
|
| DC48173 |
S1P1 agonist 4 |
S1P1 agonist 4 has a better profile in both potency (EC50 < 0.05 mg/kg) and predicted human half-life (t1/2 ∼ 5 days). |
|
| DC48174 |
L-threo Lysosphingomyelin (d18:1) |
L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is an endogenous bioactive sphingolipid. L-threo Lysosphingomyelin (d18:1) is a potent S1P receptor agonist with EC50s of 19.3, 131.8, and 313.3 nM for hS1P1, hS1P3, and hS1P2, respectively. |
|
| DC48388 |
Upacicalcet sodium |
Upacicalcet (sodium) is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT). |
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