| DC48389 |
CCR2 antagonist 5 |
CCR2 antagonist 5 is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM). CCR2 antagonist 5 displays a Ki of 9.6 µM for mCCR2 binding. CCR2 antagonist 5 can be used in the research of inflammatory disease. |
|
| DC48395 |
ACT-1004-1239
Featured
|
ACT-1004-1239 is a potent, selective, orally available CXCR7 antagonist with an IC50 value of 3.2 nM. |
|
| DC48396 |
CXCR2 antagonist 2 |
CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC50 value of 95 nM. |
|
| DC48397 |
AZD4721 |
AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). AZD4721 has the potential for the research of inflammatory disease. |
|
| DC48404 |
Ghrelin receptor full agonist-2 |
Ghrelin receptor full agonist-2 is a highly potent Ghrelin receptor full agonist. |
|
| DC48420 |
Orexin B, rat, mouse TFA |
Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation. |
|
| DC48460 |
L-Glutamine-13C5,15N2 |
L-Glutamine-13C5,15N2 (L-Glutamic acid 5-amide-13C5,15N2) is the 13C- and 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells. |
|
| DC48531 |
Clorprenaline |
Clorprenaline is a potent agonist of β2-adrenergic. Clorprenaline promotes animal muscular mass growth and decreases fat accumulation. Clorprenaline is a potential new lean meat-boosting feed additive. |
|
| DC48591 |
Octamylamine |
Octamylamine is an anticholinergic and antispasmodic agent. |
|
| DC48606 |
UCSF686 |
UCSF686 is a probe with which to study the function of the 5-HT5AR. UCSF686 loses affinity at 5-HT5AR (>10 000 nM) but not at 5-HT1AR, 5-HT2BR, and 5-HT7R. UCSF686 controls for off-target effects. |
|
| DC48611 |
(R)-Preclamol |
(R)-Preclamol is a dopamine (DA) agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. (R)-Preclamol inhibits the locomotor activity of mice and rats in low doses. |
|
| DC48638 |
UCSF678 |
UCSF678 is a 42 nM arrestin-biased partial agonist at the 5-HT5AR with a more restricted off-target profile and decreased assay liabilities. UCSF678 is a selective probe with which to study the function of the 5-HT5AR. |
|
| DC48644 |
Zacopride hydrochloride
Featured
|
Zacopride hydrochloride is a potent antagonist of 5-HT3 receptor with a Ki of 0.38 nM. Zacopride hydrochloride is also a agonist of 5-HT4 receptor with a Ki of 373 nM. Zacopride hydrochloride has anxiolytic activity. Zacopride hydrochloride has the potential for the research of Schizophrenia. |
|
| DC48645 |
5-HT2A receptor agonist-1 |
5-HT2A receptor agonist-1 shows the agonist activity at the 5-HT2A receptor with an EC50 of 5.54 nM. |
|
| DC48667 |
Tegaserod |
Tegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity. |
|
| DC48688 |
CXCR2 antagonist 3 |
CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues. |
|
| DC48689 |
Ro 01-6128 |
Ro 01-6128 is a positive allosteric modulator of mGluR1. |
|
| DC48691 |
Dioxopromethazine |
Dioxopromethazine is an orally active antihistamine. Dioxopromethazine inhibits asthmatic symptoms. |
|
| DC48710 |
Ridogrel |
Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities. |
|
| DC48719 |
Neldazosin |
Neldazosin is a potent alpha1-adrenoceptor antagonist. |
|
| DC48760 |
Lu AA33810 |
Lu AA33810 is a potent and selective antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the human receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects. |
|
| DC48787 |
LE 300 |
LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay. |
|
| DC48823 |
SB-328437
Featured
|
SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. |
|
| DC48831 |
GPBAR1-IN-3 |
GPBAR1-IN-3 (Compound 14) is a selective GPBAR1 agonist (EC50=0.17 μM) and a CysLT1R antagonist. |
|
| DC48869 |
Sequifenadine |
Sequifenadine is a H1-antihistamine. Sequifenadine has the potential for the research of inflammatory eye disease with allergic symptoms. |
|
| DC48870 |
Prifinium bromide |
Prifinium bromide is antimuscarinic agent with antispasmodic, antiemetic effect. |
|
| DC48907 |
S-777469 |
S-777469 is a selective and orally available cannabinoid type 2 receptor (CB2) agonist with a Ki of 36 nM. S-777469 significantly suppresses compound 48/80-induced scratching behavior in mice in a dose-dependent manner. S-777469 produces its antipruritic effects by inhibiting itch signal transmission through CB2 agonism. |
|
| DC48913 |
CM398
Featured
|
CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice. |
|
| DC48918 |
(S)-Butaprost free acid |
(S)-Butaprost (free acid) is a potent and highly selective agonist of EP2 receptor. |
|
| DC48919 |
Noladin ether |
Noladin ether is a potent and selective agonist of cannabinoid CB1 receptor, with a Ki of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception. |
|
