| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC5083 | Cinacalcet (AMG-073) HCl Featured | AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism. |
|
| DC20660 | AMG-076 | AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM). |
|
| DC8514 | AMG-1 Featured | AMG-1 is a potent inhibitor of human c-Met and RON with IC50 values of 4 and 9 nmol/L respectively. |
|
| DC20661 | AMG-1694 | AMG1694 is a potent, small molecule Glucokinase (GK)-GKRP (GK regulatory protein) disruptor, does not block the GK binding site directly. |
|
| DC7056 | AMG-208 Featured | AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM. |
|
| DC9793 | AMG232 | AMG232 is a potent, selective and orally bioavailable inhibitor of MDM2−p53 interaction with IC50 value of 9.1 nM in EdU cells . |
|
| DC8845 | AMG337 Featured | AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays. |
|
| DC10101 | AMG-3969 Featured | AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC 50 of 4 nM. |
|
| DC23850 | AMG-458(AMG458;AMG 458) | AMG-458 (AMG458) is a potent, selective, orally bioavailable c-Met inhibitor with Ki of 1.2 nM (human c-Met). |
|
| DC7001 | AMG-47a Featured | AMG-47a is a potent inhibitor of Lck and T cell proliferation; exhibits anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. |
|
| DC20664 | AMG-548 Featured | AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ; shows >1,000-fold selectivity over other 36 kinases, and is efficacious in acute and chro |
|
| DC11878 | AMG-579 | AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM. |
|
| DC12430 | AMG7703 | AMG7703 (4-CMTB, AMG-7703) is an allosteric, selective agonist of FFAR2 (GPR43).. |
|
| DC10132 | AMG9810 Featured | AMG9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). |
|
| DC11180 | Amgen 16 | Amgen16 is a highly potent inhibitor of NF-κB inducing Kinase (NIK), example 294 in patent WO 2009158011 A1.. |
|
| DC8503 | AMG-Tie2-1 Featured | AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC50 <1 nM). |
|
| DC8292 | AMI-1 Featured | AMI-1 is a PRMT and HIV-1 RT polymerase inhibitor. |
|
| DC9548 | Amicarbazone | Amicarbazone(BAY-MKH3586; BAY314666) is a potent inhibitor of photosynthetic electron transport via binding to the Qb domain of photosystem II (PSII); herbicide with a broad spectrum of weed control. |
|
| DCAPI1263 | Amidopyrine | Amidopyrine is white crystalline substance used as an analgesic and antipyretic. |
|
| DCAPI1043 | Amikacin hydrate | Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. |
|
| DC8984 | Aminoglutethimide | Aminoglutethimide is an aromatase inhibitor with IC50 of 10 μM. |
|
| DC11324 | Aminopeptidase N Inhibitor | Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). |
|
| DC11193 | Aminopyridine 2 | Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively. |
|
| DC9189 | Amiodarone HCl | Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. |
|
| DC20206 | Amitriptyline；MK-230, N-750, Ro41575 | Amitriptyline is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. |
|
| DC9181 | Amlodipine Besylate | Amlodipine besylate is a long-acting calcium channel blocker. |
|
| DCAPI1067 | Ammonium Glycyrrhizinate (AMGZ) | Ammonium Glycyrrhizinate (AMGZ) |
|
| DC20178 | Pyrrolidinedithiocarbamate ammonium;APDC, PDTC Featured | Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines. |
|
| DC20188 | Amodiaquine | Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria. |
|
| DC8923 | AS-1413(Amonafide) | Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
|
