| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11289 | AM-0466 Featured | AM-0466 is a potent and selective NaV1.7 Inhibitor (Nav 1.7 IC50 = 21 nM; Nav 1.5 IC50 =>30.0 uM. PXR = 22% @10 uM; CYP 2C9 IC50 = 4.6 uM; CYP3A4 TDI IC50 =>50.0 uM.). |
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| DC11181 | AM-0561 | AM-0561 (AM0561) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 0.3 nM.. |
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| DC8621 | AM095 Featured | AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. |
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| DC8622 | AM095 free acid Featured | AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. |
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| DC9909 | AM2099 Featured | AM-2099 is a potent and selective NaV1.7 Inhibitor. |
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| DC12230 | AM211 Featured | AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist |
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| DC9830 | AM-2394 Featured | AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. |
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| DC8765 | AM251 Featured | AM251 is a potent CB1 receptor antagonist (IC50 = 8 nM, Ki = 7.49 nM) that displays 306-fold selectivity over CB2 receptors; also potent GPR55 agonist (EC50 = 39 nM). |
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| DC23485 | AM-5262 | AM-5262 is a potent full GPR40 (FFA1) agonist with EC50 of 81 nM. |
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| DC23435 | AM-6226 | AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM. |
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| DC8886 | Iodopravadoline(AM-630) Featured | AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 µM and 31.2 nM, respectively. |
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| DC11552 | AM-6538 | AM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM.. |
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| DC9447 | AM679 | AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively. |
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| DC11221 | AM9405 | AM9405 (AM-9405) is novel potent, peripherally active cannabinoid type 1 (CB1) and 5-HT3 receptor agonist, inhibits the EFS-induced twitch contraction of the ileum and the colon with IC50 of 0.076 and 45.71 nM, respectively. |
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| DC8623 | AM966 Featured | AM966 is a high affinity, selective, oral LPA1 (lysophosphatidic acid receptor, IC50=17 nM) antagonist, with selectivity for this receptor over the other LPA receptors. |
|
| DC8958 | Amantadine HCl | Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug. |
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| DC10372 | Amcasertib(BBI503) Featured | Amcasertib(BBI503) is an orally administered investigational agent designed to inhibit cancer stem cell pathways, including Nanog, by targeting stemness kinases. |
|
| DC5056 | AMD3465 Featured | AMD3465 is a Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). |
|
| DC20792 | Amelubant | Amelubant (BIIL284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist, inhibits LTB4-induced mouse ear inflammation with ED50 of 0.008 mg/kg (p.o.). |
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| DC10621 | Amenamevir Featured | Amenamevir, also known as ASP2151, is a herpes virus helicase-primase inhibitor. |
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| DC7356 | Ametantrone Featured | Ametantrone is a new anthracenedione antineoplastic agents, produced a concentration-dependent inhibition of hepatic microsomal lipid peroxidation. |
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| DC8618 | AMG-319 Featured | AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3Kδ that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits basal AKT phosphorylation, and inhibits proliferation in lymphoid tumor cells |
|
| DC11239 | AMG-333 Featured | AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. |
|
| DC7055 | AMG517 Featured | AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM. |
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| DC12002 | AMG 580 | AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM. |
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| DC9457 | AMG 837 (calcium hydrate) | AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
|
| DC7867 | AMG-837 Featured | AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
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| DC6310 | AMG 853(AMG853;Vidupiprant) | AMG 853 is novel a CRTH2 and DP Dual Antagonist. |
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| DC9366 | AMG 900 Featured | AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM; >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. |
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| DC8397 | AMG 925 Featured | AMG 925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively; with IC50 of 19 nM in MOLM-13 cell. |
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