| DC21601 |
Epertinib |
Epertinib (S-222611) is a novel potent, orally active, reversible EGFR and HER2 inhibitor with IC50 of 1.48, 7.15 and 2.49 nM for EGFR, HER2 and HER4, respectively. |
|
| DC20374 |
EphB3-IN-1 |
EphB3-IN-1 is the first potent, selective inhibitor of EphB3 that exhibits inhibiting EphB3 autophosphorylation in cells with IC50 of 3 nM. |
|
| DC11433 |
Vatiquinone |
EPI-743 (Vatiquinone,EPI-589) is an orally bioavailable para-benzoquinone for treatment of inherited mitochondrial diseases, an analogue of the antioxidant ubidecarenone. |
|
| DC9363 |
Epibrassinolide |
Epibrassinolide (EBR; B1105; 24-Epibrassinolide) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family; was shown as a potential apoptotic inducer in various cancer cells without affecting the non-tumor c |
|
| DC9467 |
Epinastine
Featured
|
Epinastine(WAL801) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.
|
|
| DC23786 |
Epolactaene |
Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells. |
|
| DC7120 |
Epothilone A |
Epothilone A is a Taxol-like microtubule-stabilizing agent that induces tubulin polymerization, leading to cell cycle arrest at the G2-M transition, cytotoxicity, and apoptosis. |
|
| DC4198 |
Epothilone B
Featured
|
Epothilone B is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. |
|
| DC7012 |
Epothilone D |
Epothilone D(Desoxyepothilone B; KOS 862) is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. |
|
| DC8030 |
Epoxomicin
Featured
|
Epoxomicin is a selective and irreversible inhibitor of 20S proteasome with an IC50 value of 4 nM. |
|
| DC12311 |
Eprobemide (LIS 630)
Featured
|
Eprobemide is a non-competitive reversible inhibitor of monoamine oxidase A. |
|
| DC12529 |
EPZ020411 dihydrochloride |
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
|
| DC23134 |
EPZ020411 hydrochloride |
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
|
| DC20996 |
EPZ 025654 |
EPZ025654 (GSK 35336023) is a potent, selective arginine methyltransferase CARM1 inhibitor with IC50 of 3 nM. |
|
| DC22657 |
EPZ-030456 |
EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM. |
|
| DC8595 |
Equisetin |
Equisetin is an N-methylserine-derived acyl tetramic acid produced by a number of Fusarium species with antibiotic and cytotoxic activity. |
|
| DC20997 |
ER000444793
Featured
|
ER-000444793 is a potent, cyclophilin D-independent inhibitor of mitochondrial permeability transition pore (mPTP) with with IC50 of 2.8 uM. |
|
| DC22468 |
ER-27319 maleate |
ER-27319 maleate is a potent, selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells by selective inhibition of FcɛRI-mediated activation of Syk. |
|
| DC22090 |
ER-464195-01 |
ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5. |
|
| DC22433 |
ER-819762 |
ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay. |
|
| DC11238 |
ERD03 |
ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish. |
|
| DC21416 |
ERGi-USU |
ERGi-USU (NSC139021) is a small molecule that selectively inhibits ERG-positive cancer cell growth (VCaP cell IC50=0.169 uM), directly binds the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature. |
|
| DC22441 |
Eritoran tetrasodium |
Eritoran tetrasodium (E5564) is an investigational drug for the treatment of severe sepsis that acts as a TLR4 antagonist.. |
|
| DC22486 |
Erlotinib mesylate
Featured
|
Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated. |
|
| DC7409 |
E-Mycin |
Erythromycin, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis. |
|
| DC10211 |
Escin |
Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut). |
|
| DC21000 |
ESI-05
Featured
|
ESI-05 is a potent EAPC2-specific antagonist that inhibits cAMP-mediated EPAC2 GEF activity with apparent IC50 of 0.43 uM. |
|
| DC8443 |
ESI-09
Featured
|
ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA. |
|
| DC9565 |
Eslicarbazepine (acetate) |
Eslicarbazepine acetate (BIA 2-093) is an antiepileptic drug.
|
|
| DC12325 |
Eslicarbazepine (BIA 2-194) |
Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures. |
|
