| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC22090 | ER-464195-01 | ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5. |
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| DC22433 | ER-819762 | ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay. |
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| DC11238 | ERD03 | ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish. |
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| DC21416 | ERGi-USU | ERGi-USU (NSC139021) is a small molecule that selectively inhibits ERG-positive cancer cell growth (VCaP cell IC50=0.169 uM), directly binds the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature. |
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| DC22441 | Eritoran tetrasodium | Eritoran tetrasodium (E5564) is an investigational drug for the treatment of severe sepsis that acts as a TLR4 antagonist.. |
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| DC22486 | Erlotinib mesylate Featured | Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated. |
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| DC7409 | E-Mycin | Erythromycin, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis. |
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| DC10211 | Escin | Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut). |
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| DC21000 | ESI-05 Featured | ESI-05 is a potent EAPC2-specific antagonist that inhibits cAMP-mediated EPAC2 GEF activity with apparent IC50 of 0.43 uM. |
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| DC8443 | ESI-09 Featured | ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA. |
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| DC9565 | Eslicarbazepine (acetate) | Eslicarbazepine acetate (BIA 2-093) is an antiepileptic drug. |
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| DC12325 | Eslicarbazepine (BIA 2-194) | Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures. |
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| DC23056 | esperamicin A1 Featured | Esperamicin A1 is an enediyne antitumor antibiotics of bacterial origin. |
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| DC9440 | Estropipate Featured | Estropipate is a form of estrogen, used to treat symptoms of menopause, also used to prevent osteoporosis. |
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| DC3162 | Eszopiclone | Eszopiclone is a nonbenzodiazepine hypnotic which is slightly effective for insomnia. |
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| DC7770 | Etamicastat | Etamicastat is a novel dopamine β-hydroxylase inhibitor |
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| DC21003 | ETC-206 Featured | ETC-206 (ETC-1907206) is a novel potent, selective MNK1/2 inhibitor with IC50 of 64/86 nM, inhibits eIF4E phosphorylation inhibition in HeLa cell line with IC50 of 321 nM. |
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| DC10267 | Ethosuximide | Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures. |
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| DC12182 | Ethyl docosa-4,7,10,13,16,19-hexaenoate | Ethyl cis-4,7,10,13,16,19-Docosahexaenoate, the ethyl ester of Docosahexaenoate (DHA), is enriched in the ethyl ester fraction by the selective alcoholysis of fatty acid ethyl esters originating from tuna oil with lauryl alcohol. |
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| DC8821 | Etifoxine Hydrochloride Featured | Etifoxine Hydrochloride is a psychotropic agent with anxiolytic and anticonvulsant activity. Etifoxine Hydrochloride is an activator of GABAA R β2 and GABAA R β3. |
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| DC9441 | Etonogestrel | Etonogestrel is a steroidal progestin used in hormonal contraceptives. |
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| DC2102 | Etoposide 4'-Phosphate | Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
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| DC10239 | Etoricoxib Featured | Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties. |
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| DC4234 | Etravirine | Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1). |
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| DC9884 | Etretinate | Etretinate is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. |
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| DC20376 | Etriciguat | Etriciguat is a novel potent, selective, orally available soluble guanylate cyclase (sGC) stimulator.. |
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| DC12061 | Eurycomanone | Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis. |
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| DC9893 | Evans Blue | Evans Blue is a potent inhibitor of the uptake of L-glutamate into synaptic vesicles, also an AMPA/kainate receptor antagonist |
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| DC7987 | Encenicline hydrochloride (EVP-6124) Featured | Encenicline hydrochloride (EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). |
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| DC21005 | EXEL-0346 | EXEL-0346 (EXEL0346) is a novel potent, orally active Glucosylceramide synthase (GCS) inhibitor with IC50 of 2 nM. |
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