Novel potent and orally active activator of PP2A

Negative control for DT2216

Potent and selective degrader of mutant FKBP12F36V fusion proteins

Antiviral agent against influenza A, parainfluenza Sendai, coxsackie A21, and rhinovirus

Irreversible DNA minor groove binding alkylating agent, disrupting the nucleic acid architecture and leading to tumor cell death

Anthracycline antibiotic from Streptomyces

Selective 5-HT2A receptor antagonist

Potent and selective 5-HT 2A receptor antagonist

Novel potent and highly selective inhibitor of VEGFR, exhibiting antitumor activities both in vitro and in vivo.

Novel and potent leukotriene B(4) receptor antagonist

Novel Hsp70 agonist, showing no cellular toxicity and induced cellular stress response pathways

Novel allosteric inhibitor of the tumor-promoting interaction between the oncogenic factor AIMP2-DX2 and HSP70

Antitumor antibiotic

Novel Selective and Potent EGFR Inhibitor, Overcoming T790M-Mediated Resistance in Non-Small Cell Lung Cancer

Novel potent Inhibitor of PI3Kalpha

Novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt/β-catenin signaling

γ-Secretase modulator (GSM) photoaffinity probe, revealing distinct allosteric binding sites on presenilin

Potent Activator of P53-Independent Cellular Senescence

Novel XIAP BIR2 domain-binding degrader of E3 ubiquitin ligases

Sigma1 receptor ligand and potential atypical antipsychotic

Novel degrader of GST-α and GST-α-EGFP fusion proteins as well as endogenous GST-π in cells and lysates

Highly potent and selective activator of isozymes CA-VA and CA-VII