Novel inhibitors

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Cat. No.	Product Name	Field of Application
DC23943	K-7174 dihydrochloride Featured	K-7174 dihydrochloride is a selctive small molecule inhibitor of the transcription factor GATA-binding protein 2 (GATA2).
DC20568	Tec Kinase-IN-6	A selecitve small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 8.9 uM.
DC23996	Capadenoson Featured	Capadenoson is a selective agonist of adenosine-A1 receptor.
DC21853	Ogerin Featured	A selective GPR68 positive allosteric modulator (pEC50=6.83) with minimal PAM activity at the related proton-sensing GPCRs GPR4 and GPR65.
DC20596	O-phenanthroline	A selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM.
DC22980	ND-336	A selective inhibitor of the gelatinases MMP2 and MMP9 and MMP13 with Ki of 85, 150 and 120 nM, respectively.
DC21127	HT-0411	A selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 1.4 uM, with less potency for MT-1 and MT-2.
DC23235	Flupirtine	A selective neuronal potassium channel (KCNQ/KV7 channel) activator that also has indirect NMDA receptor antagonist and GABAA receptor modulatory properties.
DC26069	SR-11237 Featured	SR-11237 is a selective pan retinoid X receptor (RXR) agonist with no retinoid A receptor (RAR) activity. .
DC22616	CJ-42794 Featured	A selective prostaglandin E receptor subtype 4 (EP4) antagonist with pKi of 8.5.
DC12014	NSC117079	A selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.
DC12013	NSC45586 Featured	A selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.
DC11946	BNBI	A selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 8 uM in T1+ flux assays, does not inhibit Kir7.1 at 100 uM.
DC20567	Tec Kinase-IN-21	A selective small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 11.7 uM.
DC20566	Tec Kinase-IN-14	A selective small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 7.0 uM.
DC25014	Cysmethynil	A selective small-molecule inhibitor of tisoprenylcysteine carboxyl methyltransferase (Icmt) with IC50 <200 nM, does not inhibit other enzymes (farensyltransferase, geranylgeranyltransferase type I, and Rce1) at concentrations up to 50 uM.
DC20306	AMTB hydrochloride Featured	A selective TRPM8 channel blocker with pEC50 of 6.91 in Ca(2+) influx assay, with no activity for TRPV4 (pEC50<4.6).
DC23226	Guanfacine	A selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone.
DC24156	Metoprolol	A selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension..
DC26107	TRV0109101 hydrochloride	A selective, G protein-biased µ-opioid receptor agonist, does not promote the development of opioid-induced mechanical allodynia (OIMA) and rapidly reverses allodynia in vivo..
DC26103	TRV0109101	A selective, G protein-biased µ-opioid receptor agonist, does not promote the development of opioid-induced mechanical allodynia (OIMA) and rapidly reverses allodynia in vivo..
DC11737	GNF-6702	A selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM.
DC21728	TAK-070	A selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays.
DC20995	EP009	A selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.
DC20287	δ-secretase inhibitor 11	A selective, orally bioactive and brain permeable δ-secretase (AEP.
DC12005	Iberiotoxin	A selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK) with IC50 of 0.25 nM.
DC12006	Charybdotoxin	A selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK).
DC11884	Sercloremine hydrochloride	A selective, reversible inhibitor of MAO-A and serotonin reuptake inhibitor as an antidepressant..
DC11885	Sercloremine	A selective, reversible inhibitor of MAO-A and serotonin reuptake inhibitor as an antidepressant..
DC22971	CDE 096 Featured	CDE-096 is a highly effective plasminogen activator inhibitor-1 (PAI-1) antagonist with broad-spectrum inhibitory activity.

Novel inhibitors

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