| DC11645 |
Pitstop 2
Featured
|
A small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis. |
|
| DC23010 |
R-59949(R-59-949)
Featured
|
A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets. |
|
| DC23017 |
R 59022
Featured
|
A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets. |
|
| DC24022 |
NSC-305787 hydrochloride |
A small molecule inhibitor of Ezrin with Kd of 5.85 uM. |
|
| DC23826 |
UC-857993 |
A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction. |
|
| DC23810 |
UC-773587 |
A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction. |
|
| DC11833 |
TDP-665759 |
A small molecule inhibitor of HDM2-p53 interaction with FP IC50 of 0.7 uM. |
|
| DC25040 |
Heclin |
A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively. |
|
| DC22838 |
SCH 351125 |
A small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor. |
|
| DC11832 |
NU-8165 |
A small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 16 uM.. |
|
| DC11831 |
NU-8231 |
A small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 5.3 uM in ELISA assay. |
|
| DC11927 |
iNUB |
A small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM. |
|
| DC25031 |
C2-8 |
A small molecule inhibitor of polyglutamine (polyQ) aggregation in Huntington's disease neurons. |
|
| DC22761 |
NCI-83633
Featured
|
A small molecule inhibitor of PP2C that activates extensive 3' cleavage at a concentration 50-fold below that required by fluoride or CP.. |
|
| DC22552 |
IC-87201
Featured
|
A small molecule inhibitor of PSD-95/nNOS interaction with IC50 of 31 uM, without inhibiting nNOS catalytic activity. |
|
| DC20360 |
DIDS |
A small molecule inhibitor of RAD51-mediated homologous recombination. |
|
| DC25034 |
Lin28-IN-1632 |
A small molecule inhibitor of RNA binding protein Lin28 that blocks the Lin28/let-7 interaction, rescues let-7 processing and function in Lin28-expressing cancer cells. |
|
| DC23774 |
MS-444 |
A small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 7 nM. |
|
| DC23773 |
Okicenone |
A small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 90 nM. |
|
| DC22852 |
Sortase-IN-6e |
A small molecule inhibitor of Staphylococcus aureus sortase with IC50 of 9.3 uM. |
|
| DC22984 |
IT-603
Featured
|
A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays. |
|
| DC22833 |
KKL-35
Featured
|
A small molecule inhibitor of trans-translation that has broad-spectrum antibiotic activity. |
|
| DC21166 |
JK-273 |
A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin. |
|
| DC22832 |
Filastatin
Featured
|
Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect. |
|
| DC23982 |
Navoximod (GDC-0919; NLG-919)
Featured
|
Navoximod (GDC-0919; NLG-919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. |
|
| DC21415 |
Ferristatin II |
A small molecule iron transport inhibitor that promotes degradation of transferrin receptor-1 in vitro and in vivo, through a nystatin-sensitive lipid raft pathway. |
|
| DC23314 |
UNC-2170 maleate |
A small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain. |
|
| DC20453 |
MitoBloCK 6 |
A small molecule mitochondrial protein import blocker that inhibits Erv1 oxidase activity. |
|
| DC21795 |
VJ115 |
A small molecule NADH oxidase ENOX1 inhibitor with IC50 of 10 uM. |
|
| DC12018 |
MRS 1477 |
A small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM). |
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