| DC23762 |
PDI inhibitor 16F16
Featured
|
PDI inhibitor 16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation. |
|
| DC21395 |
NPD926 |
A small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion. |
|
| DC23505 |
JVW-1009 |
A small molecule sigma receptor ligand with Ki of 96 and 70 nM for sigma 1 and sigma 2, respectively. |
|
| DC23210 |
SZL P1-41
Featured
|
A small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro. |
|
| DC20527 |
Ractopamine
Featured
|
A small molecule TAAR1 agonist and β adrenoreceptor agonist that stimulates β1 and β2 adrenergic receptors. |
|
| DC21557 |
RB-011 |
A small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells. |
|
| DC11926 |
NDMC101
Featured
|
A small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo. |
|
| DC25050 |
LCL204 |
A small molecule that inhibits N-myristoyltransferase (NMT1) with IC50 of 8.7 uM, 10-fold enhanced inhibitory potency than LCL4. |
|
| DC21123 |
NSC624548 |
A small molecule that inhibits the activities of E. coli DNA polymerase I and calf thymus DNA polymerase alpha.. |
|
| DC21418 |
NSC 243928
Featured
|
NSC243928(NSC-243928 ) is a small molecule that potently inhibit ovarian cancer stem-like cells (CSC) growth with GI50 of 0.83 uM, which os consistent with cell death/apoptosis.. |
|
| DC22777 |
FPH 2(BRD9424)
Featured
|
A small molecule that promotes differentiation of iPS-derived hepatocytes. |
|
| DC20356 |
DFPM |
A small molecule that rapidly downregulates abscisic acid (ABA)-dependent gene expression (IC50=3 and 1.5 uM for RD29B and RAB18 promoters), also inhibits ABA-induced stomatal closure. |
|
| DC25025 |
Compound A5 |
A small molecule that specifically inhibits the clathrin adaptor complex AP-1-dependent traffic, does not significantly affect other pathways through the trans-Golgi network (TGN). |
|
| DC22839 |
TCA-1 |
A small molecule with activity against drug-resistant and persistent tuberculosis. |
|
| DC20387 |
Galiellalactone |
A small molecule, direct STAT3 inhibitor that inhibits the IL-6-induced SEAP expression with IC50 of 200-500 nM, blocks the binding of the activated STAT3 dimers to DNA. |
|
| DC22841 |
NBD-11021 |
A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction. |
|
| DC11498 |
FOXO1-IN-8 |
A small molecule, selective FOXO1 inhibitor that inhibits FOXO-dependent glucose production devoid of lipogenic activity in hepatocytes. |
|
| DC23032 |
OX-1 |
A small molecule, specific Measles virus (MeV) entry inhibitor with IC50 of 55 uM. |
|
| DC20659 |
(2E,4E)-5-((1S,2S,4aR,6R,7S,8S,8aS)-7-hydroxy-2,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)-2-methyl-N-(pyridin-3-yl-methyl)penta-2,4-dienamide
Featured
|
A small-molecule compound that disrupts the Golgi apparatus by inhibiting the activation of ADP-ribosylation factor 1 (ARF1). |
|
| DC21203 |
KKL-40 |
A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture. |
|
| DC22787 |
EML-633 |
A small-molecule inhibitor of Spindlin1 (SPIN1) with Kd of 2 uM. |
|
| DC22788 |
EML-631 |
A small-molecule inhibitor of Spindlin1 (SPIN1) with Kd of 4 uM. |
|
| DC22937 |
STA-21 |
A small-molecule inhibitor of STAT3. |
|
| DC20558 |
STOML3 inhibitor OB-1
Featured
|
OB-1 is a small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo; effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin; reversibly reduces the sensitiv |
|
| DC11752 |
iKIX1 |
A small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM. |
|
| DC23027 |
INP-0400 |
A small-molecule inhibitor of type III secretion in Y. pseudotuberculosis, without affecting in vitro multiplication, causes a dose- and growth phase-dependent inhibition of C. trachomatis RB multiplication.. |
|
| DC11759 |
AKCI |
A small-molecule inhibitor that blocks the Aurora C/IκBα interaction (IC50=24.9 uM) and exerts antitumor activity in MDA-MB-231 breast cancer cells. |
|
| DC22553 |
KIN-1408 |
A small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae, Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus) and Paramyxoviridae (RSVs, Nipah virus). |
|
| DC11686 |
(R)-CCX-777 |
A small-molecule partial agonist of CXCR7 (ACKR3).. |
|
| DC11687 |
(S)-CCX-777 |
A small-molecule partial agonist of CXCR7 (ACKR3).. |
|
