Cat. No. | Product name | CAS No. |
DC21373 |
HDAC6 inhibitor NCT-14b
A potent, selective HDAC6 inhibitor with IC50 of 84 nM, with IC50s of >3.5 uM for the other HDAC isoforms.. |
|
DC21461 |
PD-118057
A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells. |
313674-97-4 |
DC22946 |
ML-T531
Featured
ML-T531 is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM. |
791127-70-3 |
DC22990 |
HIF1-IN-2
A potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB. |
159915-87-4 |
DC25054 |
Gambogic amide
A potent, selective high affinity TrkA receptor agonist with Kd of 75 nM. |
286935-60-2 |
DC22966 |
ABH hydrochloride
Featured
A potent, selective human Arginase inhibitor with Ki of 0.25 uM (pH=7.5), 8.5 nM (pH=9.5) for type II arginase. |
194656-75-2 |
DC11857 |
BAY-8040 (R)
Featured
Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension. |
1194453-23-0 |
DC22454 |
IMPDH2-IN-5
A potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with IC50 of 620 nM (inhibition of NO production). |
2119603-25-5 |
DC20345 |
CLK inhibitor 2
A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively. |
1005776-20-4 |
DC11644 |
Pitstop 1
A potent, selective inhibitor of clathrin-independent endocytosis with IC50 of 18 uM (inhibition of clathrin TD-amphiphysin B/C complex formation). |
1332879-51-2 |
DC11700 |
Chalcone 4 hydrate
A potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM. |
1202866-96-3 |
DC22897 |
KRH-1636
A potent, selective inhibitor of CXCR4 with IC50 of 13 nM, has no effect on CXCR1, CCR3, CCR4, or CCR5. |
568526-77-2 |
DC22847 |
L-870810
A potent, selective inhibitor of HIV integrase (IC50=8-15 nM) with potent antiviral activity in cell culture and good pharmacokinetic properties. |
410544-95-5 |
DC11706 |
R-10015
Featured
A potent, selective inhibitor of human LIMK1 with IC50 of 38 nM . |
2097938-51-5 |
DC23189 |
CL-82198
Featured
CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression. |
307002-71-7 |
DC22658 |
Windorphen
A potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2 uM). |
19881-70-0 |
DC23910 |
Microcystin-LR
A potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM. |
101043-37-2 |
DC11967 |
PF-06649298
A potent, selective inhibitor of the Na+/citrate transporter NaCT (SLC13A5) that shows inhibition of citrate uptake in the HEKNaCT cells with IC50 of 0.41 uM. |
1854061-16-7 |
DC22754 |
SKA-111
A potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM. |
1369170-24-0 |
DC23551 |
PF-05388169
A potent, selective IRAK4 inhibitor with IC50 of 0.094 nM, >500-fold selectivity over IRAK1 (IC50=65 nM). |
1604034-78-7 |
DC23550 |
PF-05387252
A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM). |
1604034-71-0 |
DC11507 |
CLP257
Featured
CLP257 (CLP-257) is a potent, selective K+-Cl- cotransporter KCC2 activator with EC50 of 616 nM; displays selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, and a panel of 55 other receptors; restores impaired Cl(-) transport i |
1181081-71-9 |