Novel inhibitors

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Cat. No.	Product Name	Field of Application
DC11578	VHL Ligand 3 Featured	A VHL ligand for PROTAC..
DC11581	VHL Ligand 4	A VHL ligand for PROTAC..
DC11580	VHL-2	A VHL ligand for PROTAC..
DC23096	BCX-4430	A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator.
DC25095	BCX4430 freebase	A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator.
DC22579	Retaspimycin hydrochloride	A water-soluble derivative of 17-AAG and HSP90 inhibitor.
DC22983	Minnelide	A water-soluble prodrug of triptolide that is highly effective in reducing pancreatic tumor growth and spread, and improving survival.
DC22868	Propofol	A widely used general anesthetic to induce and maintain anesthesia.
DC23233	AH 6809 Featured	A xanthone derivative that fuctions as an EP and DP receptor antagonist.
DC22878	LB-205	A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo.
DC11491	A-1048400	A-1048400(A 1048400) is a novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.
DC10920	A12B4C3	A12B4C3 (hPNKP inhibitor A12B4C3) is a specific, noncompetitive inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase (hPNKP) with C50 of 60 nM, displays no inhibition of calcineurin and protein phosphatase-1 or APTX.
DC12702	A1874 Featured	A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells).
DC7044	A-205804	A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
DC11490	A-317567	A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM.
DC23659	A-357300	A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM, does not inhibit MetAP1 or leucine aminopeptidases at 10 uM.
DC10129	A395 Featured	A-395 potently inhibited the formation of H3K27me3 (via antagonizing EED in the trimeric PRC2 complex (EZH2:EED:SUZ12)) with IC50 = 34 ± 2 nM (Hill Slope = 0.7)
DC20610	A-395N	A-395N is the negative control compound of A-395, which is a potent, selective, and cellularly active PRC2 subunit EED inhibitor with Kd of 1.5 nM..
DC20611	A4250 Featured	A4250 (A-4250, Odevixibat) is a small molecule ileal bile acid transporter (IBAT) inhibitor for the treatment of cholestatic liver diseases including progressive familial intrahepatic cholestasis and NASH..
DC12317	A-484954	A-484954 is a highly selective eukaryotic elongationfactor-2 (eEF2) inhibitor, with an IC50 of 280 nM.
DC20612	A-68930 hydrochloride	A-68930 is a potent, specific, orally bioavailable agonist of the D1 Dopamine receptor with EC50 of 2.5 nM.
DC7351	A-740003	A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively).
DC11372	A-779 Featured	A-779 is a peptide antagonist of the Mas receptor, also known as the angiotensin (1-7) (Ang (1-7)) receptor (IC50 = 0.3 nM in a radioligand binding assay).
DC7785	A-790742	A-790742 is a potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor, with 50% effective concentrations ranging from 2 to 7 nM against wild-type HIV-1.
DC20614	A-832234	A-832234 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 19 nM..
DC23183	A-836339	A-836339 (A836339) is a potent and selective cannabinoid CB2 receptor agonist with Ki of 0.64 and 0.76 nM for human and rat CB2 receptors, displays 425- and 189-fold selectivity over CB1 receptor, respectively.
DC9516	A-867744	A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X.
DC22721	A-943931 dihydrochloride	A-943931 dihydrochloride is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively.
DC22720	A-943931	A-943931 is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively.
DC7046	A-966492 Featured	A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.

Novel inhibitors

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