| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC20819 | BMS-919373 | BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration. |
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| DC22445 | BMS-933043 | BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively. |
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| DC23411 | BMS-952048(BMS952048;BMS 952048) | BMS-952048 is a positive allosteric modulator of mGluR5 with EC50 of 10 nM.. |
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| DC20820 | BMS-961955 | BMS-961955 is an potent, allosteric inhibitor of HCV NS5B polymerase with EC50 of 7.9/4.3 nM for GT 1b/1a replicon respectively. |
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| DC23143 | BMS-983970 | BMS-983970 (BMS983970) is a potent, orally active, pan-Notch inhibitor, demonstrates robust anti-tumor activity at tolerated doses in multiple tumor xenograft models.. |
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| DC22035 | BMS-984923 | BMS-984923 (BMS-984923) is a potent silent allosteric modulator (SAM) of mGluR5 with competitive antagonism of MPEPy binding with Ki of 0.6 nM, but has no detectable agonist and antagonist activity at mGluR5 signaling. |
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| DC23873 | BMS-986115 | BMS-986115 is an orally bioavailable, γ-secretase and pan-Notch inhibitor with potential antineoplastic activity. |
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| DC23459 | BMS-986118 | BMS-986118 is a potent and selective GPR40 agonist with EC50 of 70 and 63 nM for hGPR40 and mGPR40, shows no PPARγ activity (EC50>47 uM). |
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| DC26073 | BMS-986122 Featured | BMS-986122 is a potent positive allosteric modulator of μ-opioid receptor, significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by an EC10 (30 pM) concentration of endomorphin-I in CHO-μ cells.. |
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| DC23609 | BMS-986163 | BMS-986163 is a water-soluble phosphate prodrug of BMS-986169, which is a novel GluN2B negative allosteric modulator (Ki=4.0 nM).. |
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| DC12174 | Deucravacitinib(BMS986165) Featured | BMS-986165 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2). |
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| DC23639 | BMS-986169 | BMS-986169 is a novel GluN2B negative allosteric modulator, demonstrates high binding affinity for the GluN2B allosteric site (Ki=4.0 nM) and selective inhibition of GluN2B receptor function (IC50=24 nM) in cells. |
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| DC23460 | BMS986187 Featured | BMS-986187 is a novel potent, positive allosteric modulator of δ-opioid receptor with EC50 of 30 nM, 100-fold selectivity over μ-opioid receptor.. |
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| DC10924 | BMS986202 Featured | BMS-986202 is a clinical Tyk2 inhibitor that binds to Tyk2 JH2 with IC50 of 0.19 nM and shows remarkably selectivity over other kinases including Jak family members. |
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| DC22036 | BMT-046091 | BMT-046091 (BMT046091) is a potent and selective AAK1 inhibitor with IC50 of 2.8 nM. |
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| DC11989 | BMT-090605 | BMT-090605 (BMT 090605, BMT090605) is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 0.6 nM. |
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| DC9937 | BMT-145027 | BMT-145027 is a potent mGluR5 PAM with no inherent mGluR5 agonist activity. |
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| DC23998 | BMX-IN-1 Featured | BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity. |
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| DC7377 | BMY 7378 Featured | BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3. |
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| DC23754 | BNC-1 | BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1, a transcriptional repressor of presenilin-1 but not presenilin-2. |
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| DC7773 | BNC-105 Featured | BNC105 is a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. |
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| DC23262 | BNM-III-170 | BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo. |
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| DC23243 | BNM-III-170 trifluoroacetate | BNM-III-170 TFA salt is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo. |
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| DC20823 | BNS-22 | BNS-22 is a small-molecule inhibitor of DNA topoisomerase II, inhibits kinetoplast DNA decatenation that is mediated by human TOP2α and TOP2β in vitro with IC50 of 2.8 and 0.42 uM, respectively. |
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| DC20034 | Boc-MLF TFA | Boc-MLF (TFA) is a peptide, used as a specific formyl peptide receptor (FPR) antagonist, also inhibits the signaling through formyl peptide receptor like 1 (FPRL1) at higher concentrations. |
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| DC9547 | Boldenone Undecylenate | Boldenone undecylenate(Equipoise) is a synthetic steroid which has a similar effect as the natural steroid testosterone; it is frequently used in veterinary medicine, though it is also used in humans. |
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| DC21869 | Borussertib Featured | Borussertib is a potent, first-in-class, covalent-allosteric AKT inhibitor. |
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| DC12405 | BOS172722 Featured | BOS172722 (BOS-172722) is a potent, selective MPS1 kinase inhibitor with biochemical IC50 of 11 nM, 100-fold selectivity over CDK2. |
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| DC9437 | Bosentan | Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors. |
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| DC23896 | Box5 | Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist. |
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