Novel inhibitors

You can also try the following methods, and our professionals will serve you Customized Consultation

Cat. No.	Product Name	Field of Application
DC20805	BMS-641988	BMS-641988 is a potent, selective, nonsteroidal androgen receptor antagonist with Ki of 1.7 nM, MDA-MB-453 cell IC50 of 16 nM.
DC20811	BMS-654457	BMS-654457 is a potent, reversible and direct inhibitor of factor XIa (FXa) with Ki of 0.4 nM.
DC22034	BMS-699	BMS-699 (BMS699) is a novel potent, selective, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50 of 0.1 nM (CKα).
DC23482	BMS-741672	BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain..
DC20813	BMS-751324	BMS-751324 is a novel clinical prodrug of BMS-582949, which is a highly selective p38α MAPK inhibitor with IC50 of 13 nM.
DC9861	BMS-779788(XL-652) Featured	BMS-779788(XL652) is a novel small-molecule modulator of the Liver X Receptor (LXR), a nuclear hormone receptor implicated in a variety of cardiovascular and metabolic disorders.
DC9638	BMS-794833	BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7/15 nM; also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378.
DC20814	BMS-795311	BMS-795311 is a potent and orally available CETP inhibitor with IC50 of 3.8 nM, inhibits cholesteryl ester (CE) transfer with IC50 of 0.22 uM.
DC7089	BMS-806 (BMS 378806)	BMS-806 (BMS 378806) is a small molecule gp120/CD4 inhibitor with an IC50 of median 5 nM.
DC10494	BMS813160 Featured	BMS-813160 is a dual CCR2/CCR5 chemokine antagonist.
DC23526	BMS-817399	BMS-817399 is a potent, selective, orally bioavailable CCR1 antagonist with binding IC50 of 1 nM, inhibits MIP-1α-induced chemotaxis with IC50 of 6 nM.
DC12635	BMS-818251	BMS-818251 (BMS818251) is a novel potent, small-molecule inhibitor of HIV-1 entry with EC50 of 0.019 nM against e laboratory-adapted HIV-1 strain NL4-3.
DC12512	BMS-823778 free base	BMS-823778 (BMS823778) is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2.
DC7154	BMS-833923 (XL-139) Featured	BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhi
DC23891	BMS-869780	BMS-869780 is a potent γ-secretase modulator (GSM) that decreases Aβ1-42 (IC50=5.1 nM) and Aβ1-40 (IC50=25.1 nM) and increases Aβ1-37 and Aβ1-38 without inhibiting overall levels of Aβ peptides or other APP processing intermediates.
DC20817	BMS-871	BMS-871 is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively.
DC20818	BMS-884775	BMS-884775 is a potent, selective P2Y1 antagonist with IC50 of 0.12 nM.
DC11990	BMS-901715	BMS-901715 is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor..
DC11862	BMS-906024	BMS-906024 is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively.
DC20819	BMS-919373	BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration.
DC22445	BMS-933043	BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively.
DC23411	BMS-952048(BMS952048;BMS 952048)	BMS-952048 is a positive allosteric modulator of mGluR5 with EC50 of 10 nM..
DC20820	BMS-961955	BMS-961955 is an potent, allosteric inhibitor of HCV NS5B polymerase with EC50 of 7.9/4.3 nM for GT 1b/1a replicon respectively.
DC23143	BMS-983970	BMS-983970 (BMS983970) is a potent, orally active, pan-Notch inhibitor, demonstrates robust anti-tumor activity at tolerated doses in multiple tumor xenograft models..
DC22035	BMS-984923	BMS-984923 (BMS-984923) is a potent silent allosteric modulator (SAM) of mGluR5 with competitive antagonism of MPEPy binding with Ki of 0.6 nM, but has no detectable agonist and antagonist activity at mGluR5 signaling.
DC23873	BMS-986115	BMS-986115 is an orally bioavailable, γ-secretase and pan-Notch inhibitor with potential antineoplastic activity.
DC23459	BMS-986118	BMS-986118 is a potent and selective GPR40 agonist with EC50 of 70 and 63 nM for hGPR40 and mGPR40, shows no PPARγ activity (EC50>47 uM).
DC26073	BMS-986122 Featured	BMS-986122 is a potent positive allosteric modulator of μ-opioid receptor, significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by an EC10 (30 pM) concentration of endomorphin-I in CHO-μ cells..
DC23609	BMS-986163	BMS-986163 is a water-soluble phosphate prodrug of BMS-986169, which is a novel GluN2B negative allosteric modulator (Ki=4.0 nM)..
DC12174	Deucravacitinib(BMS986165) Featured	BMS-986165 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).

Novel inhibitors

Customized Consultation X

Your information is safe with us. * Required Fields.