| DC12412 |
cIAP1 E3 ligase inhibitor D19 |
cIAP1 E3 ligase inhibitor D19 (cIAP1 inhibitor D19) is a small-molecule inhibitor of E3 ligase activity of cIAP1, inhibits cIAP1 auto-ubiquitination with IC50 of 14.1 uM, shows no effect on autoubiquitination of BRCA1/BARD1. |
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| DC12413 |
cIAP1 E3 ligase inhibitor D19-14 |
cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro. |
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| DC12285 |
CID 1375606
Featured
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CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27. |
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| DC22056 |
CID 9998128 |
CID 9998128 is a potential multi-target drug for the Alzheimer's disease (AD), inhibits the Aβ42 amyloid fibrillization and is capable to clear Aβ42 fibrils. |
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| DC12243 |
CID-1067700 |
CID-1067700 is a pan GTPase inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM. |
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| DC20895 |
CID3528206 |
CID3528206 is a potent, small molecule yeast TORC1 inhibitor that inhibits TORC1 activity both in vitro and in vivo with IC50 of 150 nM and 3.9 uM, respectively. |
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| DC7385 |
CID-755673
Featured
|
CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM; exhibits selective PKD1 inhibition when compared with AKT, PLK1, CAK, CAMKIIα, and PKC isoforms. |
|
| DC23753 |
CID888706 |
CID888706 is a small molecule, pan activator of Rho-family GTPases.. |
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| DC20904 |
CIDD 0067106 |
CIDD 0067106 is a novel natural product-based diaryloxazole that potent and selective antiproliferative activities against androgen receptor-positive breast cancer cells (MDA-MB-453 cell GI50=0.8 uM). |
|
| DC11374 |
Cilastatin |
Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. |
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| DC9325 |
Cilazapril (monohydrate)
Featured
|
Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
|
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| DC20341 |
Ciliobrevin D
Featured
|
Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of cytoplasmic dynein, blocks dynein-dependent microtubule gliding and ATPase activity while sparing kinesin dependent cellular trafficking. |
|
| DC9582 |
Cilomilast |
Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. |
|
| DC22028 |
Ciluprevir |
Ciluprevir (BILN2061) is a potent HCV NS3/4A protease inhibitor with Ki of 0.66 and 0.30 nM for NS3-NS4A protease of HCV 1b and HCV 1a, respectively. |
|
| DC12134 |
Cimiside B |
Cimiside B, a glycoside alkaloid, isolated from the rhizome of Cimicifuga dahurica. |
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| DC20093 |
Cinchonine ((8R,9S)-Cinchonine; LA40221)
Featured
|
Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. |
|
| DC9896 |
Cinnarizine
Featured
|
Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker. |
|
| DC21572 |
Cipemastat |
Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9). |
|
| DC9603 |
Ciprofibrate |
Ciprofibrate is a peroxisome proliferator-activated receptor agonist.
|
|
| DCAPI1372 |
Ciprofloxacin (Cipro)
Featured
|
Ciprofloxacin (Bay-09867) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. |
|
| DC9466 |
Ciproxifan (maleate)
Featured
|
Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.
|
|
| DC12100 |
Cirsimaritin |
Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities. |
|
| DC20342 |
cis Ned-19 |
cis Ned-19 is the stereoisomer of trans Ned-19, a chemical probe for the Ca(2+)-releasing second messenger NAADP. |
|
| DC9517 |
Cisatracurium (besylate)
Featured
|
Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.
|
|
| DC20906 |
CJ-13610
Featured
|
CJ-13610 is a potent 5-Lipoxygenase (5-LO) inhibitor that suppresses 5-LO product formation with IC50 of 70 nM. |
|
| DC20907 |
CK 666
Featured
|
CK 666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM, inhibits actin polymerization with either BtArp2/3 complex (IC50=17 uM) or SpArp2/3 complex (IC50=5 uM). |
|
| DC20343 |
CK1-IN-3c |
CK1-IN-3c is a novel casein kinase 1δ/ε (CK1δ/ε) inhibitor with IC50 of 1.6 uM. |
|
| DC20344 |
CK2-IN-1 |
CK2-IN-1 is a potent, competitive inhibitor of ATP binding to Casein kinase 2(CK2) with IC50 of 9 nM, induces differentiation of epidermal progenitor cells to terminally differentiated keratinocytes with EC50 of 0.1 uM.. |
|
| DC11107 |
CKD-516 |
CKD-516 (Valecobulin, CKD516) is a potent beta-tubulin polymerization inhibitor with marked antitumor activity both in vitro and in vivo. |
|
| DC11098 |
CKD-519 |
CKD-519 (Rocacetrapib, CKD519) is a potent, selective cholesteryl ester transfer protein (CETP) inhibitor, inhibits the CETP-mediated transfer of cholesteryl ester in human serum with IC50 of 2.3 nM. |
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