| DC8070 |
Fexarene
Featured
|
Fexarene is a potent, selective farnesoid X receptor agonist. |
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| DC8071 |
Fexarine
Featured
|
Fexarine is a potent, selective farnesoid X receptor agonist. |
|
| DC8195 |
FG2216
Featured
|
FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo. |
|
| DC5193 |
Roxadustat(FG-4592)
Featured
|
FG-4592 is an HIF αprolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production. |
|
| DC11187 |
Fonadelpar |
Fonadelpar (NPS-005,SJP-0035) is a potent, selective peroxisome proliferator activated receptor δ (PPARδ) agonist for the treatment of corneal disorders.. |
|
| DC12062 |
GDC-0927 Racemate |
GDC-0927 Racemate is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. |
|
| DC10347 |
Gestrinone |
Gestrinone (R2323) is a synthetic steroid hormone used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM. |
|
| DC11845 |
GNE-3500 |
GNE-3500 (GNE3500) is a potent, selective, and orally bioavailable RORγ inhibitor with IC50 of 47 nM in IL-17 promoter assays. |
|
| DC11189 |
GNE-6468 |
GNE-6468 (GNE6468) is a potent and selective RORc inverse agonist (EC50=2 nM) with >1,000-fold selectivity for RORc over PPARγ. |
|
| DC1036 |
GSK-0660
Featured
|
GSK-0660 is a selective PPARδ antagonist (IC50 values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ respectively). |
|
| DC11415 |
GSK2033
Featured
|
GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively. |
|
| DC9738 |
GSK2881078
Featured
|
GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness. |
|
| DC9713 |
GSK2981278
Featured
|
GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). |
|
| DC1035 |
GSK3787
Featured
|
GSK3787 is as a potent and selective antagonist of PPARδ with pIC50 of 6.6. |
|
| DC7566 |
GW-4064
Featured
|
GW 4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). |
|
| DC2078 |
GW-7647
Featured
|
GW 7647 is a potent PPARα agonist with 200-fold selectivity over PPARγ and PPARδ. |
|
| DC9904 |
GW0742
Featured
|
GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ in binding assay, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively. |
|
| DC7149 |
GW1929
Featured
|
GW1929 is a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist with IC50 of 6.2 nM and 13 nM for human and mouse, respectively. |
|
| DC7837 |
GW-3965 hydrochloride
Featured
|
GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. |
|
| DC4233 |
GW501516
Featured
|
GW501516 is the most selective and potent PPARβ (EC50=1.1nM) agonist that has been demonstrated to be 1,000-fold more selective in comparison to existing subtypes. |
|
| DC2079 |
GW-9662
Featured
|
GW9662 is a selective PPAR antagonist, inhibiting PPARγ, PPARα and PPARδ with IC50 of 3.3 nM, 32 nM and 2 μM, respectively. |
|
| DC11010 |
H3B-5942 |
H3B-5942 is an orally available, selective estrogen receptor covalent antagonist (SERCA), demonstrates potent ERαantagonist activity in vitro and in vivo. |
|
| DC11167 |
HX600 |
HX600 (HX-600) is a synthetic agonist of RXR-Nurr1 heterodimer complex, also selectively activate NGFI-B/RXR heterodimers. |
|
| DC10237 |
Hydroxyprogesterone caproate |
Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibits ovulation and an alteration in the cervical mucus and endometrium. |
|
| DC8166 |
Molidustat(BAY 85-3934)
Featured
|
Hypoxia-inducible factor prolyl hydroxylase inhibitor |
|
| DC11782 |
IDF-11774
Featured
|
IDF-11774 is a novel hypoxia-inducible factor α (HIFα)-1 inhibitor with an IC50 of 3.65 μM. |
|
| DC7430 |
Obeticholic acid (INT-747)
Featured
|
INT-747(Obeticholic acid; 6-ECDCA) is a potent and selective FXR agonist(EC50=99 nM) endowed with anticholestatic activity. |
|
| DC10825 |
IOX4
Featured
|
IOX4 is a potent inhibitor of PHD2 (IC50 = 1.6 nM). |
|
| DC8617 |
JNJ-42041935
Featured
|
JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. |
|
| DC11237 |
KB-141 |
KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα. |
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