| DCAPI1150 |
Calcitriol (Rocaltrol)
Featured
|
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist. |
|
| DC4160 |
CB-03-01
Featured
|
CB-03-01 is a steroidal ester, androgen antagonist derived from 11-deoxycortisone, which tightly mimics the profile of an ideal anti-androgen for topical use. |
|
| DC10617 |
CBL0137
Featured
|
CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. |
|
| DC10955 |
CD12681 |
CD12681 (CD-12681) is a potent, selective RORγ inverse agonist with IC50 of 19 nM, displays no activity against a panel of nuclear receptors (RORα, RARγ, LXRβ, PPARγ and VDR). |
|
| DC10491 |
CD437
Featured
|
CD437 is a synthetic retinoid that is an RARγ-selective agonist. It displays RARγ-dependent and -independent effects on differentiation and apoptosis. |
|
| DC12025 |
CDDO imidazolide
Featured
|
CDDO-imidazolide is a potent inducer of heme oxygenase-1 and Nrf2/ARE signaling,with potent antiproliferative, differentiating, and anti-inflammatory activities. |
|
| DC9277 |
C-DIM12
Featured
|
C-DIM12 is a novel synthetic activator of Nurr1. |
|
| DC10792 |
DIM-C-pPhOCH3(C-DIM5)
Featured
|
C-DIM5 is a Nur77 agonist. Activation of the orphan nuclear receptor Nur77 by C-DIM5 is associated with decreased cancer cell survival, |
|
| DC7939 |
CH-223191
Featured
|
CH-223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. |
|
| DC10868 |
Cilofexor
Featured
|
Cilofexor (GS-9674, GS9674) is novel specific, non-steroidal farnesoid X receptor (FXR) agonist that reduces liver fibrosis and ameliorates portal hypertension in rat NASH models. |
|
| DC9183 |
Clomiphene citrate |
Clomifene Citrate is a selective estrogen receptor modulator. |
|
| DC8694 |
Cortodoxone |
Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone). |
|
| DC8188 |
Daprodustat
Featured
|
Daprodustat(GSK1278863) isa HIF-prolyl hydroxylase inhibitor. |
|
| DC11402 |
Desidustat
Featured
|
Desidustat is an inhibitor of HIF hydroxylase. |
|
| DC9604 |
Desogestrel
Featured
|
Desogestrel(Org-2969) is a third-generation 19-nortestosterone derivative progestogen; is contained in many oral contraceptive preparations, both combined (COCs) to ethinyl-estradiol (EE) or alone in a progestin-only pill (POP). |
|
| DC9605 |
Dienogest
Featured
|
Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. |
|
| DCAPI1241 |
Doxercalciferol (Hectorol)
Featured
|
Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease. |
|
| DCAPI1441 |
Seocalcitol |
EB1089 is an analog of 1,25 dihydroxyvitamin D which acts as a vitamin D receptor (VDR). EB1089 is noted to reverse hypercalcemia and is a potent inhibitor of PTH-rP (parathyroid hormone-related peptide, PTHRP) in vitro. In studies utilizing a squamous ca |
|
| DC10182 |
Elacestrant (dihydrochloride)
Featured
|
Elacestrant dihydrochloride (RAD1901 dihydrochloride) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. |
|
| DC10727 |
Elafibranor(GFT505)
Featured
|
Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively. |
|
| DC8177 |
Enclomiphene citrate
Featured
|
Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. |
|
| DC9959 |
Endoxifen (E-isomer)
Featured
|
Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). |
|
| DC8265 |
Endoxifen
Featured
|
Endoxifen is a Estrogen receptor α (ERα) ligand; potent antiestrogen,an active metabolite of the cancer drug tamoxifen. |
|
| DC8856 |
EPI-001
Featured
|
EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator |
|
| DC9441 |
Etonogestrel |
Etonogestrel is a steroidal progestin used in hormonal contraceptives.
|
|
| DCAPI1084 |
Ezetimibe (Zetia)
Featured
|
Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. |
|
| DC9086 |
Fenofibrate |
Fenofibrate is PPARα agonist with EC50 of 18 μM and 30 μM for mouse and human PPARα, respectively. |
|
| DC7714 |
Fenretinide (4-HPR)
Featured
|
Fenretinide (4-HPR) is a synthetic retinoid deriverative. 4-HBR is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death. |
|
| DC8069 |
Fexaramate
Featured
|
Fexaramate is a potent, selective farnesoid X receptor agonist. |
|
| DC8085 |
Fexaramine
Featured
|
Fexaramine is a potent, selective FXR activator. |
|
