DC12055 |
DC1-SMe |
DC1-Sme is an antibody conjugate of phosphate prodrug of cytotoxic DNA alkylators for the targeted treatment of cancer. |
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DC12554 |
DC661
Featured
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DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1). |
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DC20175 |
Ripretinib (DCC-2618)
Featured
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DCC-2618 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of the tumor-associated antigens (TAA) mast/stem cell factor receptor (SCFR) KIT and PDGFR-alpha, with IC50 values of 4 nM, 8 nM, 18 nM, 5 nM and 14 nM. |
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DC24137 |
DCVC |
DCVC (S-(1,2-dichlorovinyl)-L-cysteine) is an active metabolite of trichloroethylene. |
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DCAPI1304 |
D-Cycloserine |
D-Cycloserine |
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DC12593 |
DD-03-171 |
DD-03-171 is a small molecule, CGI1746-based BTK degrader (PROTAC, biochemical IC50=5.1 nM) that efficiently degrade C481S-BTK, exhibits enhanced anti-proliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading BTK, IKFZ1 and IKFZ3. |
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DC20947 |
DDD 85646
Featured
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DDD 85646 is a potent, specific, dual N-Myristoyltransferase NMT1/NMT2 inhibitor with IC50 of 17 nM/22 nM respectively. |
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DC12521 |
DDR1 inhibitor 2.45 |
DDR1 inhibitor 2.45 (Compound 2.45) is a novel potent, selective, bioavailable Discoidin Domain Receptor 1 (DDR1) inhibitor with IC50 of 29 nM, displays 64-fold selectivity over DDR2 in biochemical assays. |
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DC23844 |
DDR1 inhibitor 7rh |
DDR1 inhibitor 7rh is a potent, selective, ATP-competitive, orally available Discoidin domain receptor 1 (DDR1) inhibitor with IC50 of 6.8 nM in cell-free kinase assays. |
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DC7398 |
DDR1-IN-1
Featured
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DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with IC50/EC50 of 105 nM/87 nM; 4-fold less potent for DDR2 (IC50= 413 nM). |
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DC23857 |
DDR2-IN-5 |
DDR2-IN-5 is a potent, dual DDR2/SRC inhibitor with IC50 of 56/12 nM, potently suppresses DDR2 mutated cell lines HCC-366 and NCI-H2286 with IC50 of 0.44 uM and 0.29 uM.. |
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DC12560 |
DDR-TRK-1 |
DDR-TRK-1 (DDR1 inhibitor 6j) is a potent, selective selective DDR1 inhibitor with IC50 of 9.4 nM, also potently inhibits TRK family with IC50 of 18-100 nM. |
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DC4193 |
Decitabine
Featured
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Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively. |
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DC12144 |
Decursin ((+)-Decursin)
Featured
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Decursin is an anticancer agent, with potential anti-inflammatory activity. |
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DC10822 |
Defensamide(MHP)
Featured
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Defensamide, also known as MHP and methyl caprooyl tyrosinate, is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC. |
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DCAPI1107 |
Deferasirox (Exjade)
Featured
|
Deferasirox (Exjade) |
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DC7399 |
Deferitrin
Featured
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Deferitrin (GT-56-252) is the first drug in a class of desferrithiocin-derived hexadentate iron chelators. |
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DC11332 |
Degarelix (acetate)
Featured
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Degarelix is a synthetic gonadotropin-releasing hormone receptor (GNRHR) antagonist (IC50 = 3 nM in HEK293 cells expressing the human receptor). |
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DC9337 |
Deguelin
Featured
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Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor effect on several cancers; decrease levels of phosphorylated Akt.
|
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DC5201 |
Dehydroepiandrosterone (DHEA) |
Dehydroepiandrosterone(DHEA) is a 19-carbon endogenous natural steroid hormone. |
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DC23727 |
Dehydromutactin |
Dehydromutactin is a small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 40 nM. |
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DC12073 |
Dehydronitrosonisoldipine |
Dehydronitrosonisoldipine is a calcium channel antagonist. |
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DC10458 |
Delafloxacin(ABT-492)
Featured
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Delafloxacin (RX-3341, ABT-492) is a fluoroquinolone antibiotic agent. |
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DC20116 |
Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine)
Featured
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Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and |
|
DC20772 |
Deleobuvir |
Deleobuvir (BI-207127, BI207127) is a potent, selective HCV NS5B polymerase inhibitor with IC50 of 50 nM against GT-1 HCV polymerase activity. |
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DC20948 |
Deltasonamide 2 |
Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM. |
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DC26004 |
delta-Valerobetaine (hydrobromide)
Featured
|
Delta-Valerobetaine (hydrobromide) is a precursor of trimethylamine N-oxide (TMAO). |
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DC20949 |
Deltazinone 1 |
Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM. |
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DC10850 |
Dencichine |
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity. |
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DC7199 |
Denibulin (MN-029) |
Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. |
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