| DC20229 |
Datelliptium chloride
Featured
|
Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities. |
|
| DC25058 |
Daunorubicin
Featured
|
Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells. |
|
| DC20942 |
DB04760 |
DB04760 is a potent, highly selective, non–zinc-chelating MMP-13 inhibitor with IC50 of 8 nM, displays high selectivity over other MMPs. |
|
| DC8826 |
DB07268
Featured
|
DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM. |
|
| DC22067 |
DB1055 |
DB1055 (DB-1055, DB 1055) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence. |
|
| DC20943 |
DB2115 |
DB2115 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM. |
|
| DC23251 |
DB213
Featured
|
DB213 (RG-501) is a small molecule stimulator of HIV-1 frameshifting and inhibitor of viral replication. |
|
| DC12516 |
DB550 |
DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM. |
|
| DC12517 |
HT105 |
DB550 (DB-550, TCWKHRK) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction, abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 38 nM. |
|
| DC22069 |
DB818
Featured
|
DB818 (DB-818, DB 818) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence. |
|
| DC21882 |
DBCO acid 1 |
DBCO acid 1 is a Click Chemistry intermidate used for antibody-drug conjugates.. |
|
| DC21883 |
DBCO acid 2 |
DBCO acid 2 is a Click Chemistry intermidate used for antibody-drug conjugates.. |
|
| DC21884 |
DBCO acid 3 |
DBCO acid 3 is a Click Chemistry intermidate used for antibody-drug conjugates.. |
|
| DC21885 |
DBCO acid 4 |
DBCO acid 4 is a Click Chemistry intermidate used for antibody-drug conjugates.. |
|
| DC21886 |
DBCO acid 5 |
DBCO acid 5 is a Click Chemistry intermidate used for antibody-drug conjugates.. |
|
| DC21888 |
DBCO intermidate 1 |
DBCO intermidate 1 is a Click Chemistry intermidate used for antibody-drug conjugates.. |
|
| DC21889 |
DBCO intermidate 2 |
DBCO intermidate 2 is a Click Chemistry intermidate used for antibody-drug conjugates.. |
|
| DC21890 |
DBCO intermidate 3
Featured
|
DBCO intermidate 3 is a Click Chemistry intermidate used for antibody-drug conjugates.. |
|
| DC21891 |
DBCO Maleimide |
DBCO Maleimide is a Click Chemistry intermidate used for antibody-drug conjugates.. |
|
| DC20355 |
DBCO-NHS ester 2 |
DBCO-NHS ester 2 is a derivative of DBCO (Dibenzylcyclooctyne) used in Cu-free click chemistry. |
|
| DC22076 |
DBCO-NHS ester 3 |
DBCO-NHS ester 3 (DIBAC-NHS) is a Click Chemistry intermidate used for antibody-drug conjugates.. |
|
| DC21987 |
DBCO-PEG4 amine |
DBCO-PEG4 amine (ADIBO-PEG4-amine) is a Click Chemistry intermidate used for antibody-drug conjugates.. |
|
| DC7602 |
DBeQ
Featured
|
DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM. |
|
| DC21892 |
dBET23 |
dBET23 is a BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=50 nM) in cellular degradation assays.. |
|
| DC21893 |
dBET57
Featured
|
dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2.. |
|
| DC12665 |
DBPR114
Featured
|
DBPR114 is a quinazoline-based multi-kinase inhibitor for the treatment of acute myeloid leukemia and other solid tumors. |
|
| DC23976 |
DC_517 |
DC_05 is a potent, selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 1.7 uM, displays significant selectivity toward other AdoMet-dependent protein methyltransferases. |
|
| DC23977 |
DC-05
Featured
|
DC-05 is a selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 10.3 uM, displays 3.6-fold selectivity over PRMT1 and >15-fold over DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9.. |
|
| DC20945 |
DC_AC50
Featured
|
DC_AC50 (DCAC50) is a small molecule that inhibits the human copper chaperones Atox1 and CCS (Kd=6.8 and 8.2 uM), blocks copper trafficking and significantly attenuates cancer cell proliferation. |
|
| DC12361 |
DC1 |
DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. |
|
